Epidemiology, Pathogenesis and Immunity of Adenovirus

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 6 March 2026 | Viewed by 715

Special Issue Editors


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Guest Editor
Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA
Interests: adenovirus; genetic variability; molecular epidemiology and pathogenesis of human adenovirus acute respiratory infections
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Idaho Veterans Research and Education Foundation, Boise Veterans Administration Medical Center, Boise, ID 83702, USA
2. Department of Biological Sciences, Boise State University, Boise, ID 83702, USA
Interests: adenoviral gene control of host inflammatory responses to virally infected cells and related modulation of cellular innate immune responses and immunopathogenesis; viral oncogene effects on neoplastically transformed cell susceptibility to antitumor effects of natural killer cells and activated macrophages
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Human adenoviruses (HAdVs) represent a diverse group of pathogens responsible for a wide spectrum of clinical manifestations ranging from mild respiratory tract infections to severe multi-organ disease. Understanding the epidemiology and pathogenesis of adenovirus infections is crucial for developing effective prevention strategies and therapeutic interventions.

This Special Issue aims to explore the multifaceted aspects of adenovirus infections, encompassing studies on viral epidemiology, transmission dynamics, host susceptibility factors, and the underlying mechanisms of viral pathogenesis. Contributions are invited to delve into the molecular virology of adenoviruses, including viral entry, replication strategies, and immune evasion mechanisms. Additionally, epidemiological investigations should shed light on disease trends, outbreak scenarios, and the impact of adenovirus infections on public health.

Prof. Dr. Adriana Kajon
Dr. Jay R. Radke
Guest Editors

Manuscript Submission Information

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Keywords

  • human adenovirus
  • viral infection
  • pathogenesis
  • epidemiology
  • immune response
  • diagnosis
  • therapeutics
  • vaccine development

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Published Papers (1 paper)

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Research

12 pages, 858 KiB  
Article
Modulation of the Inflammatory Response by Adenovirus 36 in Patients with Obesity and Type 2 Diabetes: A Nested Case-Control Study Within a Cohort
by Itzae Adonai Gutiérrez-Hurtado, Erika Martínez-López, Manuel Alejandro Rico-Méndez, Karla Mayela Bravo-Villagra, Héctor Eduardo Mendoza-Jaramillo, María del Pilar Sánchez-Rolón, Alejandra Betancourt-Núñez, Martha Patricia Gallegos-Arreola, José Carlos Tapia-Rivera and Andres López-Quintero
Viruses 2025, 17(4), 552; https://doi.org/10.3390/v17040552 - 10 Apr 2025
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Abstract
Human adenovirus 36 (HAdV-36) is associated with obesity, potentially by promoting adipocyte proliferation and differentiation. Although linked to increased fat storage, HAdV-36 is also correlated with improved insulin sensitivity. Given its potential role in modulating adipose tissue and promoting a less inflammatory metabolic [...] Read more.
Human adenovirus 36 (HAdV-36) is associated with obesity, potentially by promoting adipocyte proliferation and differentiation. Although linked to increased fat storage, HAdV-36 is also correlated with improved insulin sensitivity. Given its potential role in modulating adipose tissue and promoting a less inflammatory metabolic profile, its impacts on pro- and anti-inflammatory cytokine secretion remain unclear. Methods: This nested case-control study compared cytokine levels (IL-10, IL-2, IL-6, IL-8, and TNF-α) between patients with and without HAdV-36 infection. A total of 76 participants were included, with 37 in the control group (HAdV-36 negative) and 39 classified as cases (HAdV-36 positive). Results: HAdV-36 seropositive individuals exhibited significantly lower IL-6 levels and higher IL-8 levels than seronegative participants. Additionally, they had lower glucose levels, suggesting a potential link between HAdV-36 and metabolic regulation. Conclusions: These findings support the hypothesis that HAdV-36 may influence inflammatory and metabolic responses by modulating cytokine expression and glucose levels. Further research is needed to clarify the underlying mechanisms and their implications for metabolic health. Full article
(This article belongs to the Special Issue Epidemiology, Pathogenesis and Immunity of Adenovirus)
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