Regulation of HIV-1 Transcription and Latency, 2nd Edition
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 373
Special Issue Editor
Special Issue Information
Dear Colleagues,
The Special Issue “Regulation of HIV-1 Transcription and Latency”, which was launched in 2023, successfully garnered a number of informative articles on this important topic. We would like to introduce a second edition of this Special Issue, intended to update our understanding of the transcriptional control of HIV-1 latency via viral and host factors.
Residual cellular subsets of transcriptionally latent, but potentially inducible, HIV-1 reservoirs in infected people on antiretroviral therapy are considered to be the ultimate barrier to finding a cure for HIV-1 infection. Dissecting the host and viral mechanisms that are utilized by HIV-1 to emerge from latency is therefore crucial for the development of strategies to either eliminate or permanently silence persistent HIV-1 reservoirs. In the second edition of this Special Issue, we will maintain the theme of publishing review and research articles focused on host and viral mechanisms of HIV-1 transcriptional regulation as well as their applications for HIV-1 eradication or permanent silencing. In light of the fact that virtually all mechanistic studies of HIV-1 reservoirs conducted thus far have rarely utilized non-B subtypes, which are collectively responsible for 88% of the global HIV-1 infection burden, we also welcome review and original research articles that aim to incorporate an examination of the transcriptional regulation of non-B subtypes.
Dr. Uri Mbonye
Guest Editor
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Keywords
- HIV provirus
- HIV latency
- latency reversal
- HIV transcription initiation
- HIV transcription elongation
- transcription factors
- epigenetic silencing
- posttranscriptional control of HIV gene expression
- transcriptomic analysis of HIV infection
- HIV reservoir
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