Development of In Vitro Disease Modelling

Dear Colleagues,

Most of the current research focuses on understanding the cellular and molecular mechanisms of human disease pathophysiology to develop innovative and improved therapies or diagnostic tools. While small-animal models, such as transgenic mice, have been designed to achieve diseased states, they fail to completely recreate the pathogenesis as seen in humans because of their differences in gene, phenotype, and physiology with respect to humans. Furthermore, animal models would not be helpful in investigating conditions that are highly dependent on the genetic, epigenetic, or microbiome make-up of a human individual. The milestones achieved within the field of stem cell biology and tissue engineering over the last few decades have revolutionized the field of disease modeling and have the potentials to establish in vitro models from human diseased tissue that can demonstrate relevant degenerative mechanisms. In this Special Issue, we welcome both research and review manuscripts targeted towards disease modeling using engineering and stem cell approaches including , but not limited to, in vitro models of diseases of the heart, lung, intestine, liver, kidney, cartilage, skin, and vascular, endocrine, musculoskeletal, and nervous systems, as well as models of infectious diseases and cancer. We also encourage manuscripts on the use of human inducible pluripotent stem cells to recreate diseases in a dish.

Dr. Biraja Dash
Guest Editor

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