Advances in Non-Invasive Drug Delivery Systems

Dear Colleagues,

Non-invasive drug delivery systems have attracted considerable attention in recent years as an effective strategy to improve patient adherence, reduce administration-associated discomfort, and enhance therapeutic outcomes. Advances in pharmaceutical technology, biomaterials, nanotechnology, and formulation design have enabled the development of innovative delivery platforms that overcome biological barriers and facilitate drug absorption via oral, transdermal, transmucosal, pulmonary, nasal, ocular, and other non-invasive routes. These approaches are particularly relevant for the administration of poorly soluble compounds, biologics, nucleic acids, and other challenging therapeutic agents. However, despite significant progress, important challenges remain regarding formulation stability, drug permeation, targeting efficiency, controlled release, scalability, and regulatory approval. Addressing these issues requires interdisciplinary efforts involving pharmaceutical sciences, materials engineering, biotechnology, and clinical research. In this context, novel nanocarriers, responsive materials, advanced manufacturing technologies, and computational approaches have emerged as promising tools to improve the performance and translational potential of non-invasive drug delivery systems. This Special Issue aims to provide a comprehensive overview of recent advances in the design, characterization, and application of non-invasive drug delivery systems. We welcome original research articles, reviews, and communications focusing on formulation development, physicochemical and biopharmaceutical characterization, in vitro and in vivo evaluation, safety assessment, and clinical perspectives. Contributions addressing nanomedicine, nanoformulations, tissue engineering, and emerging technologies for non-invasive drug delivery are particularly encouraged. We look forward to receiving your valuable contributions.

Dr. Bruno Fonseca-Santos
Dr. Fernanda Borges de Almeida
Guest Editors

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