Polymers Enhancing Bioavailability in Drug Delivery, 2nd Edition

Dear Colleagues,

Currently, many of the drug entities entering the clinic face bioavailability issues, mainly due to poor water solubility and/or permeability, in addition to issues with physicochemical instability or degradation in the body. To overcome biological barriers, drug sensitivity, and formulation problems, the use of several polymers has been considered. Polymers, either natural or synthetic, present an array of different backbones and functional groups, sizes, shapes, as well as mechanical and degradation properties, which have been exploited in drug delivery and targeting. Strategies for bioavailability enhancement using functionalized polymers include solid amorphous dispersions for improved solubility; chemical modification for extended blood residence and reduced or abrogated immunogenicity and antigenicity; protection from harsh pH or enzymatic degradation; as well as tailored rate and temporal/spatial drug release.

This Special Issue, Polymers Enhancing Bioavailability in Drug Delivery—Volume II, aims to review the specific functional benefits granted by polymers to formulations, which are very much reliant on polymer structure and design, and result in improved drug bioavailability and therapeutic index. You are welcome to submit your research or review papers to this Special Issue, thus contributing to this exciting field.

Dr. Ana Isabel Fernandes
Guest Editor

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