Medicinal Chemistry of Indole and Quinoline Derivatives: Trends and Future Directions as Therapeutic Drugs, 2nd Edition
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 July 2025 | Viewed by 804
Special Issue Editor
Interests: indole, carbazole and quinoline chemistry; identification of new molecular templates for drug discovery; ellipticine derivatives and their mechanism of biological effect; kinase inhibitor design and synthesis of bisindolemaleimides and indolocarbazoles; phytosterols and the toxicity of their oxygenated products; quinolinediones and isoquinolinediones for the treatment of multidrug resistant disease; LCMS in the improvement of pharmaceutical process and impurity profiling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nitrogen-containing heterocycles have made an enormous contribution to medicinal and pharmaceutical chemistry since the identification of alkaloids such as morphine and strychnine. The prevalence and potency of nitrogen-containing natural products that incorporate indole and quinoline (with melatonin, quinine, serotonin, and tryptophan being other examples) frame this success. The two bicyclic ring systems have provided a rich source of diversity, upon which medicinal and pharmaceutical chemistry have thrived, and multiple examples of therapeutics with real-life benefits exist. Examples on the WHO Essential Medicines List stretch from chloroquine (discovered in 1934) to ciprofloxacin, fluvastatin, indomethacin, mefloquine, ondansetron, primaquine, quinine, and sumatriptan. More recently, aripiprazole, tadalafil, and ziprasidone are some of the most commonly prescribed medicines and highlight the tangible impact of these heterocycles on people and the treatment of their diseases. Medicinal chemistry approaches to find small-molecule lead compounds with pharmacological activity continue to use natural products, synthesis, and existing small-molecule drug libraries as sources. The focus of this series of papers is on the use of indole and quinoline as therapeutics. Pharmaceuticals invites both reviews and original articles that concern the use of indoles and quinolines in the discovery and development of pharmaceuticals. The scope of this Special Issue will cover, but is not limited to, new synthetic methods in the synthesis of indoles and quinolines, medicinal chemistry and structure–activity studies on indole and quinoline derivatives, natural product discovery involving indoles and quinolines, indole and quinoline drug repositioning, new combinations of indoles and quinolines, and indoles and quinolines beyond pharmaceutical applications. The collection of manuscripts will be published as a Special Issue of the journal.
Dr. Florence McCarthy
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- indole
- quinoline
- heterocycle
- pharmaceutical discovery and development
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