Drug Discovery, Development, and Synthesis for Glioblastoma

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 1342

Special Issue Editors


E-Mail Website
Guest Editor
Department of Medical Education, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA
Interests: drug synthesis; anticancer; medicinal chemistry; organic synthesis

E-Mail Website
Guest Editor
Department of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA
Interests: biomaterials; glioblastoma; platinum resistant ovarian cancer; bone tissue engineering
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Graduate School and School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
Interests: drug design; drug synthesis; organometallic catalyst; environmentally friendly catalysts

Special Issue Information

Dear Colleagues,

Glioblastoma is the most common and lethal malignant primary brain tumor. Glioblastoma treatments remain difficult, and for now, no curative treatments are available.

The current initial treatment includes surgery, radiation therapy, medication therapy, or a combination of these therapies. However, the overall survival rate for glioblastoma remains quite low, with these tumors often leading to death within a year of diagnosis. Many factors, such as tumor heterogeneity, tumor location in a region, and rapid, aggressive tumor relapse, make the treatment more challenging. Finding more efficacious therapies is an urgent issue.

In recent years, significant progress has been made in identifying more effective anti-glioblastoma regimens. While overall mortality rates remain high, our improved understanding of the molecular mechanisms and genetic mutations has led to more promising therapeutic approaches. This progress has shed light on the future of glioblastoma treatment.

Pharmaceuticals invites you to share your expertise in the form of reviews and original articles on the challenges of pharmaceutical treatment for glioblastoma, particularly in drug discovery, development, and synthesis, including drug discovery from natural products, biomolecules, drug modification, small-molecule synthesis, combination therapies, and other pharmaceutical applications. The collection of manuscripts will be published as a Special Issue of the journal.

Dr. Shizue Mito
Dr. Sue Anne Chew
Prof. Dr. Mitsuhiro Arisawa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glioblastoma
  • drug design
  • drug synthesis
  • anticancer
  • natural products
  • biomolecules
  • combination therapy
  • pharmaceuticals

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 2607 KiB  
Article
Repurposing Osimertinib and Gedatolisib for Glioblastoma Treatment: Evidence of Synergistic Effects in an In Vitro Phenotypic Study
by Vitória Santório de São José, Bruno Marques Vieira, Vivaldo Moura Neto and Lidia M. Lima
Pharmaceuticals 2024, 17(12), 1623; https://doi.org/10.3390/ph17121623 - 3 Dec 2024
Viewed by 1089
Abstract
Background/Objectives: Glioblastoma is a malignant tumor with a poor prognosis for the patient due to its high lethality and limited chemotherapy available. Therefore, from the point of view of chemotherapy treatment, glioblastoma can be considered an unmet medical need. This has led to [...] Read more.
Background/Objectives: Glioblastoma is a malignant tumor with a poor prognosis for the patient due to its high lethality and limited chemotherapy available. Therefore, from the point of view of chemotherapy treatment, glioblastoma can be considered an unmet medical need. This has led to the investigation of new drugs for monotherapy or associations, acting by synergistic pharmacological mechanisms. Methods: Here, we propose the combination of Osimertinib (a potent EGFR inhibitor) and Gedatolisib (a potent PI3K/mTOR dual inhibitor) through an in vitro phenotypic study using five human GB lines and establish the cytotoxic potency, selectivity, and effect on proliferation, apoptosis, and cell cycle by simultaneously inhibiting EGFR, PI3K, and mTOR. Results: Cytotoxic potency of Gedatolisib and Osimertinib in the selected GB cell lines was determined, which highlighted the synergistic response from their combination and its impact on migration reduction, G0/G1 cell cycle arrest, GB cytotoxicity, and apoptosis-inducing effects for different GB cell lines. Conclusions: From the drug combination studies in phenotypic in vitro models, it was possible to suggest a new potential treatment for glioblastoma that justifies further safe in vivo phases of preclinical trials with the combination. Full article
(This article belongs to the Special Issue Drug Discovery, Development, and Synthesis for Glioblastoma)
Show Figures

Figure 1

Back to TopTop