Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Therapies for Autoimmune Diseases submission deadline 25 Apr 2026 | Viewed by 1357 | Submission Open
Keywords: autoimmune diseases; immunotherapy; immunomodulation; biologic therapies; small molecule drugs; therapeutic vaccines; tolerogenic strategies; monoclonal antibodies; personalized medicine; targeted drug delivery
(This special issue belongs to the Section Medicinal Chemistry)
Epithelial Plasticity and Therapy Resistance in Cancer
edited by Naisana Seyedasli
submission deadline 25 Apr 2026 | 1 articles | Viewed by 1101 | Submission Open
Keywords: cancer stem cells; epithelial– mesenchymal transition; epithelial reprogramming; resistance; drug targets; resistance mechanisms; biomarker discovery
(This special issue belongs to the Section Pharmacology)
The Development and Application of Broad-Spectrum Antiviral Drugs
edited by Chieh-Wen Lo
submission deadline 25 Apr 2026 | Viewed by 506 | Submission Open
Keywords: broad-spectrum antiviral; direct-acting antiviral; host-targeted antiviral; emerging viruses; pandemic preparedness
(This special issue belongs to the Section Medicinal Chemistry)
Synthesis and Anticancer Activity of Biologically Active Heterocyclic Compounds
edited by and Rita VaickelionienÄ—
submission deadline 25 Apr 2026 | 1 articles | Viewed by 455 | Submission Open
Keywords: heterocyclic compounds; five- or six-membered heterocycles; oxygen- and nitrogen-based heterocycles; sulfur- and nitrogen-based heterocycles; azoles; small molecules; anticancer activity; cell lines; cytotoxicity
(This special issue belongs to the Section Medicinal Chemistry)
Research on Diagnosis, Treatment and Related Microbiota in Gastrointestinal Diseases
edited by and Brigida Barberio
submission deadline 25 Apr 2026 | Viewed by 395 | Submission Open
Keywords: gut microbiota; inflammatory bowel disease; eosinophilic esophagitis; primary sclerosing cholangitis; metabolic-associated steatotic liver disease; immune checkpoint inhibitor colitis; dysbiosis; prebiotics; probiotics
(This special issue belongs to the Section Medicinal Chemistry)
Natural Products and Phytomedicines: From Chemical Profiling and Pharmacological Properties to Therapeutic Applications submission deadline 25 Apr 2026 | Viewed by 178 | Submission Open
Keywords: natural products and derivatives; (nano)phytomedicine; plant extracts and phytopreparates; biochemical profiling; active principles; phytopharmacological mechanisms; signaling pathways; network pharmacology; molecular docking; pharmacokinetics and toxicity assays; clinical studies; therapeutic novelty; sustainable development
(This special issue belongs to the Section Natural Products)
Cholinesterases—Structure, Mechanism, Function and Drug Discovery
edited by
submission deadline 25 Apr 2026 | Viewed by 176 | Submission Open
Keywords: cholinesterases; cholinesterase inhibitors; structure-based design of inhibitors; multi-target ligands; non-cholinergic functions; structure; allosteric sites; mechanism; non-classical functions
(This special issue belongs to the Section Medicinal Chemistry)
Synthesis, In Silico Prediction and Antitumor Activity of Nitrogen Heterocycle-Based Drug Development
edited by Jamerson F. De Oliveira and Paulo André Teixeira de Moraes Gomes
submission deadline 25 Apr 2026 | Viewed by 175 | Submission Open
Keywords: privileged structures; nitrogen heterocycles; ADMET prediction; cancer biological target; molecular dynamic; computational studies; antitumor activity; in vitro and in vivo studies; SAR of lead compounds; molecular hybridization
(This special issue belongs to the Section Medicinal Chemistry)
Advances in and Perspectives on Oral Drug Delivery submission deadline 25 Apr 2026 | Viewed by 137 | Submission Open
Keywords: enhanced drug delivery; oral route; oral peptide delivery; 3D printing; continuous manufacturing; PBPK modeling; nanocarriers; translational pharmaceutics; low aqueous solubility and low permeability; enhanced oral bioavailability; transporter targeting; emerging materials and excipients in oral delivery; dosage form transition of already marketed drugs; examining herbal or traditional drugs oral delivery; sustained release; nanotechnology; application of cellular components such as exosomes or vesicles for oral delivery; in silico docking for PBPK; nanocarriers; lipid-based formulations; self-emulsifying drug delivery systems (SEDDS); solid dispersions; mucoadhesive systems
(This special issue belongs to the Section Pharmaceutical Technology)
Design and Development of PLGA and Polysaccharide Microparticles submission deadline 25 Apr 2026 | Viewed by 86 | Submission Open
Keywords: drug delivery systems; polymeric systems; nanotechnology; controlled release
(This special issue belongs to the Section Medicinal Chemistry)
Emerging Therapeutic Strategies for Heart Diseases
edited by Elias Rawish
submission deadline 25 Apr 2026 | Viewed by 85 | Submission Open
Keywords: medicinal chemistry; drug design; SAR; molecular modeling; pharmacophore; cardiovascular targets; inflammation; complement; neutrophils/NETosis; fibrosis; ion channels; SGLT2; GLP-1; biomarkers; binding affinity; PK/PD; ADME; radiopharmaceuticals; PET/SPECT; dosage form design; bioconjugates; prodrugs; nanoparticles; exosomes; siRNA/ASO/mRNA; peptides; antibodies; aptamers; targeted drug delivery; early clinical trials
(This special issue belongs to the Section Pharmacology)
Application and Translational Research of Lanthanide/Nanomaterial-Conjugated Photosensitizers in Photodynamic Therapy
edited by
submission deadline 25 Apr 2026 | Viewed by 80 | Submission Open
Keywords: lanthanide-based nanomaterials; nanomaterial-conjugated photosensitizers; photodynamic therapy (PDT); targeted delivery; upconversion luminescence; preclinical evaluation; translational research; biocompatibility
(This special issue belongs to the Section Pharmaceutical Technology)
Next-Generation Approaches for Cartilage Regeneration
edited by and Liam Morris
submission deadline 25 Apr 2026 | Viewed by 68 | Submission Open
Keywords: cartilage regeneration; cartilage engineering; bioactive molecules (peptides/proteins/nucleic acids); biomaterials (therapeutic delivery); gene engineering (biopharmaceutical applications); chondrogenic signaling pathways; preclinical/clinical evaluation (cartilage repair); osteoarthritis (therapeutic interventions); therapeutic targets (cartilage repair); translational regenerative medicine
(This special issue belongs to the Section Biopharmaceuticals)
Natural Products with Anticancer Activity
edited by
submission deadline 25 Apr 2026 | Viewed by 67 | Submission Open
Keywords: natural products; extracts; anticancer activities; phytochemicals; molecular mechanisms
(This special issue belongs to the Section Medicinal Chemistry)
Pharmaceutical and Biomaterial Approaches for Preventive and Restorative Dentistry
edited by Jan Kiryk and
submission deadline 25 Apr 2026 | Viewed by 59 | Submission Open
Keywords: dental prophylaxis; restorative dentistry; pharmaceuticals; biomaterials; dental innovations; dentistry of the future
(This special issue belongs to the Section Pharmacology)
Pleiotropic Agents and Their Therapeutic Potential in Gastroenterology, Angiology, and Musculoskeletal Disorders
edited by , Mario Starešinić, and Alenka Boban Blagaic
submission deadline 25 Apr 2026 | 1 articles | Viewed by 58 | Submission Open
Keywords: pleiotropic agents; therapeutic potential; tissue repair; angiogenesis; gastroenterology; musculoskeletal disorders
(This special issue belongs to the Section Biopharmaceuticals)
Progress of Hydrogel Applications in Novel Drug Delivery Platforms, 2nd Edition submission deadline 25 Apr 2026 | Viewed by 53 | Submission Open
Keywords: hydrogels; targeted drug delivery; drug release; drug delivery; smart hydrogels; stimuli-responsive hydrogels; controlled release; hydrogel-based drug delivery; drug carriers
(This special issue belongs to the Section Pharmaceutical Technology)
microRNAs and Perioperative Pharmacology
edited by and María Dolores Carmona-Luque
submission deadline 25 Apr 2026 | Submission Open
Keywords: miRNAs; pharmacology; anesthetics; perioperative; biomarkers; breast cancer; ischemic heart disease; gene regulation; therapeutics; non-coding
(This special issue belongs to the Section Pharmacology)
Natural Products and Bioactive Compounds for the Prevention and Treatment of Non-Communicable Chronic Diseases
edited by
submission deadline 26 Apr 2026 | 3 articles | Viewed by 1407 | Submission Open
Keywords: natural products; phytochemicals; chronic diseases; functional foods; herbal medicine; non-communicable diseases; ethnopharmacology; bioactivity
(This special issue belongs to the Section Natural Products)
Plant-Derived Natural Compounds as Bioactive Molecules with Beneficial Effects on Human Health, 2nd Edition
edited by
submission deadline 26 Apr 2026 | 1 articles | Viewed by 554 | Submission Open
Keywords: plant bioactives; bioactive compounds; gut microbiome; immune-modulatory; antioxidant; hypocholesterolemic; antihypertensive; clinical trials
(This special issue belongs to the Section Natural Products)
New Perspectives in Ocular Pharmacology: 2nd Edition submission deadline 26 Apr 2026 | Viewed by 20 | Submission Open
Keywords: ocular pharmacology; pharmacodynamics; ophthalmology; drug delivery systems
(This special issue belongs to the Section Pharmacology)
Natural Products and Their Modifications as Agents Used in the Fight Against Pathogens, 2nd Edition
edited by
submission deadline 27 Apr 2026 | 1 articles | Viewed by 1344 | Submission Open
Keywords: plant extract; natural compounds; multidrug-resistant strains; intestinal microbiota; chemical modyfication; biotransformation
(This special issue belongs to the Section Natural Products)
Tumor Immunopharmacology, 2nd Edition submission deadline 27 Apr 2026 | Viewed by 95 | Submission Open
Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine; immunoresistance; tumor-infiltrating lymphocytes (TILs); immune escape; immune checkpoint inhibitors; cytokine-based therapies; small molecule immunomodulators; combination therapy; precision oncology; tumor mutational burden (TMB); antibody-dependent cellular cytotoxicity (ADCC ); complement-dependent cytotoxicity (CDC); myeloid-derived suppressor cells (MDSCs)
(This special issue belongs to the Section Pharmacology)
Fluoroquinolones, 2nd Edition
edited by and
submission deadline 27 Apr 2026 | Viewed by 74 | Submission Open
Keywords: fluoroquinolones; fluoroquinolone-associated disability; antibiotic safety; fluoroquinolone toxicity; antibiotic stewardship
(This special issue belongs to the Section Pharmacology)
Advances in Medicinal Chemistry: 2nd Edition
edited by
submission deadline 30 Apr 2026 | 3 articles | Viewed by 3736 | Submission Open
Keywords: drug discovery; novel drug targets; drug discovery; drug design and development; synthetic methods for drugs; analytical methodologies; in silico screening; structure and ligand-based drug design; structure– activity relationships (SAR); drug metabolism
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacological Strategies to Modulate Symptoms in Autism Spectrum Disorders (ASD)
edited by
submission deadline 30 Apr 2026 | 3 articles | Viewed by 3288 | Submission Open
Keywords: pharmacological treatment of ASD; neurodevelopmental disorders; molecular modeling and ASD; drug discovery for autism; repurposing drugs for ASD; 5-HT receptors; GABAergic system; TRPC6; mGluR5
(This special issue belongs to the Section Pharmacology)
Advances in Hydrazone Compounds with Anticancer Activity submission deadline 30 Apr 2026 | 1 articles | Viewed by 1520 | Submission Open
Keywords: hydrazones; lipophilicity; logP; anticancer activity; selectivity
(This special issue belongs to the Section Medicinal Chemistry)
Therapeutic Potential of Natural Extracts in Cancer Prevention and Treatment submission deadline 30 Apr 2026 | 1 articles | Viewed by 1302 | Submission Open
Keywords: natural products; anticancer therapeutic potential; cancer chemoprevention; mechanism of action and molecular targets; preclinical and clinical studies
(This special issue belongs to the Section Natural Products)
Pharmacological Activity and Application of Polyphenolic Compounds
edited by
submission deadline 30 Apr 2026 | Viewed by 1073 | Submission Open
Keywords: phenolic compounds; biological potential; pharmacological activity; phenolic applications; health promoters; chronic diseases
(This special issue belongs to the Section Natural Products)
Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Metabolic Diseases Prevention and Intervention submission deadline 30 Apr 2026 | 1 articles | Viewed by 935 | Submission Open
Keywords: metabolic diseases; diabetes; medicinal plants; bioactives; metabolic disorders
(This special issue belongs to the Section Natural Products)
Effects of Drug Abuse and Its Consequences on Health submission deadline 30 Apr 2026 | 1 articles | Viewed by 532 | Submission Open
Keywords: psychoactive substances; drug abuse; toxicological effects; neurotoxicity; substance use disorder; biomarkers of toxicity; public health impact; addiction mechanisms; harm reduction strategies; novel psychoactive substance (NPS)
(This special issue belongs to the Section Medicinal Chemistry)
Advancements in Radiopharmaceutical Theranostics
edited by , Shilpa Sharma and
submission deadline 30 Apr 2026 | Viewed by 358 | Submission Open
Keywords: radiopharmaceuticals; radiotheranostics; emerging radionuclides; radiometals; image-guided dosimetry; alpha-emitters; PET; SPECT; radioligand therapy; targeted radionuclide therapy
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Innovative Organic Synthesis Approaches in Drug Design and Development submission deadline 30 Apr 2026 | Viewed by 228 | Submission Open
Keywords: sustainable organic synthesis; green chemistry; drug design and development; non-traditional solvents; Lewis acid catalysis; catalytic methodologies; photoredox and electrochemical methods; medicinal chemistry innovation
(This special issue belongs to the Section Medicinal Chemistry)
Therapeutic Potential of Natural Plant-Derived Compounds in Glioblastoma and Other Brain Tumors submission deadline 30 Apr 2026 | Viewed by 146 | Submission Open
Keywords: glioblastoma; GBM; brain tumors; natural plant‑derived compounds; phytochemicals; blood– brain barrier; signaling targets; tumor microenvironment; therapeutic opportunities; targeted therapy
(This special issue belongs to the Section Natural Products)
Neuropharmacology of Plant Extracts and Their Active Compounds (Second Edition) submission deadline 30 Apr 2026 | Viewed by 118 | Submission Open
Keywords: medicinal plant; mental disorder; preclinical; clinical
(This special issue belongs to the Section Natural Products)
New Trends in the Treatment of Neuropsychiatric Disorders submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open
Keywords: treatment; depression; schizophrenia; bipolar disorder; Alzheimer’ s disease
(This special issue belongs to the Section Pharmacology)
The Therapeutic Potential of Neurotrophin Signaling in Neurodegenerative Disorders
edited by Konstantina Chanoumidou, and
submission deadline 30 Apr 2026 | Viewed by 82 | Submission Open
Keywords: central nervous system; neurodegeneration; neuroinflammation; therapy; neurotrophin receptors; regeneration; myelination
(This special issue belongs to the Section Pharmacology)
Innovative Drug Delivery and Mitochondrial-Targeted Therapies
edited by José Antonio Jara Sandoval and Alfredo E. Molina-Berríos
submission deadline 30 Apr 2026 | Viewed by 81 | Submission Open
Keywords: drug delivery; mitochondrial-targeted therapies; mitochondrial dysfunction; novel formulations; therapeutic strategies; mitocans; targeting mitochondria
(This special issue belongs to the Section Pharmacology)
Computational Predictions of Molecules with Potential Therapeutic Effects: 2nd Edition
edited by
submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open
Keywords: biophysics; medicinal chemistry; drug discovery; molecular docking; molecular dynamics; structure-activity relationships; computer-aided drug design (CADD)
(This special issue belongs to the Section Pharmacology)
Ophthalmic Drugs and Pharmacology
edited by Christin Henein and Sahar Awwad
submission deadline 1 May 2026 | Viewed by 99 | Submission Open
Keywords: ophthalmic diseases; optic neuropathies; eye diseases; glaucoma; corneal disorders; retinal degeneration; ocular surface disease
(This special issue belongs to the Section Pharmacology)
Nanocarriers in Cancer Therapy: From Drug Delivery to Radiotherapy | Pharmaceuticals submission deadline 1 May 2026 | Viewed by 21 | Submission Open
Keywords: cancer nanomedicine; lipid nanoparticles; drug delivery; radiotherapy enhancement; nanocarriers; tumor microenvironment; nano-immunotherapy; cancer vaccines; stimuli-responsive systems
(This special issue belongs to the Section Pharmaceutical Technology)
Innovative Computational and Experimental Strategies in Antimicrobial Drug Discovery submission deadline 10 May 2026 | Viewed by 44 | Submission Open
Keywords: antimicrobial resistance; multidrug resistance; small molecules; novel antimicrobial entities; in silico drug discovery; in vitro screening; innovative strategies; drug repurposing; structure– activity relationship; rational drug design
(This special issue belongs to the Section Medicinal Chemistry)
Allosteric Drug Design in the AI Era
edited by Lydia Siragusa and
submission deadline 15 May 2026 | Viewed by 80 | Submission Open
Keywords: allosteric modulation; artificial intelligence in drug discovery; computational pharmacology; allosteric sites prediction; structure-based drug design
(This special issue belongs to the Section AI in Drug Development)
Metals in Cancer Research: Beyond Platinum Metallodrugs
edited by and
submission deadline 15 May 2026 | Viewed by 60 | Submission Open
Keywords: anticancer drugs; metal complexes; non-platinum; drug resistance; targeted therapy
(This special issue belongs to the Section Medicinal Chemistry)
Novel Drug Compositions for Ischemic Stroke: Mechanisms and Clinical Applications submission deadline 20 May 2026 | 2 articles | Viewed by 2354 | Submission Open
Keywords: ischemic stroke; novel delivery systems; nanomedicine; nanotechnology; neuroregenerative therapy; neurorepair; new and emerging treatments; pharmacotherapy; tissue engineering
(This special issue belongs to the Section Pharmacology)
Solid State Chemistry and Materials Science in Pharmaceutical Research: From Solid Forms to Advanced Dosage Forms
edited by Norbert Nagel, Wenqian Chen and Raimundo Ho
submission deadline 20 May 2026 | Viewed by 145 | Submission Open
Keywords: solid forms; solid form screening; pharmaceutical salts; polymorphism; hydrates; co-crystals; materials science; manufacturing process understanding; solid dosage forms; semi-solid dosage forms; pharmaceutical amorphous solid dispersions; enabling formulations; crystal structure prediction; material science tetrahedron; computational chemistry; structure-property relationships
(This special issue belongs to the Section Pharmaceutical Technology)
Past, Present and Future Radiotracer Techniques: Radiopharmaceuticals in Cancer Theranostics: 2nd Edition submission deadline 22 May 2026 | Submission Open
Keywords: diagnostic radiotracers; therapeutic radiopharmaceuticals; theranostics; radiolabeling techniques; GMP compliance; automated synthesis and quality control; pre-clinical studies; translation into clinics and first-in-human studies; clinical trials; regulatory approval
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Pharmacogenomics for Precision Medicine, 2nd Edition
edited by
submission deadline 23 May 2026 | Viewed by 20 | Submission Open
Keywords: pharmacogenomics in precise therapy; tailored medicine; pharmacoeconomics; personalized medicine; education in pharmacogenomics and precise medicine; future directions in pharmacogenomics; pharmacogenomics and phenotype; host-bacteria interaction in pharmacogenomics; genotype; epigenetic variation; and gene expression axis in pharmacogenomics
(This special issue belongs to the Section Pharmacology)
Pediatric Drug Therapy: Safety, Efficacy, and Personalized Medicine submission deadline 25 May 2026 | 5 articles | Viewed by 19188 | Submission Open
Keywords: pediatric pharmacotherapy; drug safety in children; pediatric drug efficacy; personalized medicine in pediatrics; pediatric pharmacokinetics; pediatric pharmacodynamics; pharmacogenomics in children; pediatric clinical trials; pediatric dosing strategies; pediatric drug formulations
(This special issue belongs to the Section Pharmacology)
Artificial Intelligence-Assisted Drug Discovery
edited by Aldo Sena De Oliveira
submission deadline 25 May 2026 | 2 articles | Viewed by 10325 | Submission Open
Keywords: artificial intelligence; drug discovery; machine learning; medicinal chemistry; computational chemistry; virtual screening; ADMET predictions; de novo drug design; multi-target ligands; drug repositioning
(This special issue belongs to the Section Medicinal Chemistry)
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