Nutrition and Gut Immunity
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 39675
Special Issue Editor
Special Issue Information
Dear Colleagues,
The gastrointestinal tract harbours trillions of bacteria in the lumen, separated from the host by the first line of defence, the gut epithelium, considered as part of the innate immunity. In conjunction with the epithelium, a dense population of immune cells in the lamina propria and gut lymphoid structures prevent the uncontrolled translocation of gut bacteria into the host that could otherwise have dramatic consequences for the host, including death.
Changes in the gut immunity can have both local and systemic impacts on the host. Increased gut permeability has been observed in numerous non-communicable diseases, and the increased differentiation of Th17 in the small intestine has been shown to increase experimental autoimmune encephalitis severity in a multiple sclerosis mouse model.
A better understanding of what affects gut immunity is thus critical to prevent/treat diseases.
Diet is among the major factors that can modulate gut immunity by modulating epithelial permeability, by promoting the differentiation of anti- or pro-inflammatory cells, or by controlling immune cell activities. Diet can mediate these effects either directly or indirectly through the gut microbiota. Beneficial reshaping of the gut microbiota as well as the release of bacterial metabolites such as short chain fatty acids promote epithelial integrity and colonic regulatory T cells development, protecting from food allergy in a mouse model.
The aim of this Issue is to gather reviews and original research articles investigating the impact of diet on gut immunity, including the role of the gut microbiota and the impact on host health.
Dr. Laurence Macia
Guest Editor
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Keywords
- diet
- macronutrients
- gut epithelium
- gut immunity
- immune cell differentiation and function
- inflammation
- immunometabolism
- gut microbiota
- microbiota-derived metabolites
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