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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Peptide Chemistry: Recent Trends and Advancements
edited by Fa-Jie Chen and
submission deadline 31 Dec 2025 | Viewed by 576
Keywords: peptide synthesis; cyclic peptide; peptide ligation; peptide stapling; peptide library; peptide therapy; structure and activity
(This special issue belongs to the Section Medicinal Chemistry)
Chemical Conversion and Utilization of CO2
edited by Gang Li
submission deadline 31 Dec 2025 | 1 articles | Viewed by 541
Keywords: CO2 utilization for green synthesis; photocatalytic CO2 utilization; C-H carboxylation with CO2; green synthetic methodology development; functional materials design for CO2 utilization
(This special issue belongs to the Section Organic Chemistry)
Multifunctional Electrocatalysts for Overall Water Splitting
edited by Haeseong Jang
submission deadline 31 Dec 2025 | Viewed by 488
Keywords: electrocatalysts; water splitting; oxygen evolution reaction; hydrogen evolution reaction; nanostructure
(This special issue belongs to the Section Electrochemistry)
Bioactive Compounds in Cosmetic Applications
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 474
Keywords: bioactive compounds; peptides; herbal extract; biofermentates; upcycling; skin well-being; in vitro tests; efficacy testing
(This special issue belongs to the Section Natural Products Chemistry)
Functional Foods: Chemical Challenges and Opportunities
edited by Yan Zhang and Haixia Wu
submission deadline 31 Dec 2025 | Viewed by 391
Keywords: functional foods; chemical stability; advanced extraction methods; chemical modification; chemical bioavailability; food safety
(This special issue belongs to the Section Food Chemistry)
Exclusive Feature Papers in Natural Products Chemistry, 3rd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 388
Keywords: natural products; plant secondary metabolism; phytochemical analysis; nutrients and bioactive compounds; bioaccessibility and bioavailability; antioxidant; anti-inflammatory; anticancer
(This special issue belongs to the Section Natural Products Chemistry)
Propolis in Human and Bee Health—2nd Edition submission deadline 31 Dec 2025 | Viewed by 362
Keywords: propolis; plant sources; biological activity; bee health; bioactive compounds; pharmacological properties; analytical methods; applications
(This special issue belongs to the Section Natural Products Chemistry)
Exploring Schiff Base Ligands and Their Metal Complexes
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 341
Keywords: schiff base ligands; complexes; X-ray structure; antimicrobial; antitumor; antiviral activity; catalysts
(This special issue belongs to the Section Inorganic Chemistry)
A Special Issue Celebrating the 75th Birthday of Professor Massimo Stefani submission deadline 31 Dec 2025 | Viewed by 340
Keywords: protein aggregates; natural compounds; enzyme biochemistry; protein folding; misfolding; and aggregation; amyloid diseases; natural polyphenols; neurodegenerative disorders
(This special issue belongs to the Section Natural Products Chemistry)
Analytical Techniques in Environmental Chemistry, 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 307
Keywords: environmental analytical chemistry; contaminants; environmental impact assessment; analytical techniques; environmental pollution
(This special issue belongs to the Section Analytical Chemistry)
Natural Extracts for Pharmaceutical Applications
edited by
submission deadline 31 Dec 2025 | Viewed by 291
Keywords: natural compounds; phytochemicals; bioactive compounds; medicinal plants; phytopharmacology; antioxidant activity; anti-inflammatory; antimicrobial; antidiabetic; wound healing
(This special issue belongs to the Section Medicinal Chemistry)
Exploring Heterocyclic Compounds: Design, Synthesis and Medicinal Chemistry Applications submission deadline 31 Dec 2025 | Viewed by 280
Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodologies; structure– activity relationships (SARs); computational chemistry
(This special issue belongs to the Section Organic Chemistry)
A Theme Issue in Honor of Professor Gary E. Martin's 75th Birthday
edited by R. Thomas Williamson and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 275
Keywords: NMR; pulse sequences; natural products; pharmaceuticals; anisotropic NMR; CASE; DFT
(This special issue belongs to the Section Bioorganic Chemistry)
Advances in Ammonia Synthesis
edited by Wenbo Gao
submission deadline 31 Dec 2025 | Viewed by 271
Keywords: ammonia synthesis; heterogeneous catalysis; nitrogen activation; ammonia energy; reaction mechanism; photo/electrochemical ammonia synthesis
(This special issue belongs to the Section Applied Chemistry)
The Synthesis and Application of Rare-Earth-Doped Luminescent Materials
edited by and Rui Wang
submission deadline 31 Dec 2025 | Viewed by 266
Keywords: luminescent materials; molecular design; luminescent mechanisms and processes; display; lighting; detection
(This special issue belongs to the Section Materials Chemistry)
AI-Powered Biomolecular Modeling: Bridging Scales and Accelerating Discovery
edited by , and Hui Wang
submission deadline 31 Dec 2025 | Viewed by 260
Keywords: artificial intelligence; molecular simulations; machine learning; force field development; enhanced sampling; ab initio calculations
Biodegradable Functional Copolymers, Second Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 253
Keywords: biodegradable (co)polymers; chemical functionalization; macromolecular synthesis; macromolecular bioconjugates; environmental and biomedical applications; targeted drug delivery; tissue engineering
(This special issue belongs to the Section Macromolecular Chemistry)
Artificial Intelligence Driving Transformative Advances in Food Science and Technology submission deadline 31 Dec 2025 | Viewed by 239
Keywords: food sustainability; artificial intelligence; food processes optimization; functional foods; food safety; individualized nutrition
(This special issue belongs to the Section Food Chemistry)
Advanced Delivery Systems for Therapeutic and Agro-Chemical Applications
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 234
Keywords: micro- and nano-carriers; responsive; toxicology; safety; drug delivery
(This special issue belongs to the Section Applied Chemistry)
The Therapeutic Potential of Natural and Synthetic Anti-Inflammatories
edited by , and Wendeo Kennedy Costa
submission deadline 31 Dec 2025 | Viewed by 228
Keywords: anti-inflammatory agents; bioactive compounds; drug discovery; phytochemicals; chronic inflammation; inflammation; medicinal chemistry
(This special issue belongs to the Section Natural Products Chemistry)
Phenotypic Screening for Drug Development and Discovery
edited by Xiang Li
submission deadline 31 Dec 2025 | Viewed by 215
Keywords: phenotypic screening; drug discovery; target deconvolution; disease models; high-throughput screening; mechanism of action; translational research
(This special issue belongs to the Section Medicinal Chemistry)
Synthesis and Application of Chalcogen-Containing Organic Compounds submission deadline 31 Dec 2025 | Viewed by 208
Keywords: organoselenium compounds; organotellurium compounds; organosulfur compounds; electrophilic chalcogenation; nucleophilic chalcogenation; organochalcogen compounds in material science; elemental chalcogen; C– X bond formation (X = S; Se; Te); pharmacological properties
(This special issue belongs to the Section Organic Chemistry)
Antimicrobial Peptide Assemblies
edited by
submission deadline 31 Dec 2025 | Viewed by 205
Keywords: peptides; peptide hybrids; peptide conjugates; self-assembly; stimuli-responsiveness; antimicrobial activity
(This special issue belongs to the Section Chemical Biology)
Unique Heterocycles for Drug Discoveries
edited by
submission deadline 31 Dec 2025 | Viewed by 200
Keywords: heterocyclic compound; heterocyclic chemistry; medicinal chemistry; drug discovery; synthetic methodologies; drug design
(This special issue belongs to the Section Organic Chemistry)
Applications of Advanced Functional Materials: Electrocatalysis and Energy submission deadline 31 Dec 2025 | Viewed by 181
Keywords: functional nanomaterials; advanced catalysts; hydrogen evolution reaction (HER); sustainable energy; electrocatalysis; energy conversion
(This special issue belongs to the Section Materials Chemistry)
Feature Review Papers in Electrochemistry, 2nd Edition submission deadline 31 Dec 2025 | Viewed by 178
Keywords: electrochemical science; electrochemical technology; environmental applications; new materials; energy conversion; energy storage; electrocatalysis; combined electrochemical technologies
(This special issue belongs to the Section Electrochemistry)
Plasma Catalysis Method in Catalytic Process
edited by and Debtanu Maiti
submission deadline 31 Dec 2025 | Viewed by 171
Keywords: catalysis; energy; plasma; surface interactions; mechanism; atmospheric plasma catalysis; plasma characterization; theory and modeling
(This special issue belongs to the Section Organic Chemistry)
Sustainable Approaches to Nanoparticle Synthesis: Toward a Greener and Safer Future submission deadline 31 Dec 2025 | Viewed by 165
Keywords: green synthesis of nanoparticles; sustainable nanotechnology; eco-friendly nanomaterials; biogenic nanoparticle synthesis; plant-mediated nanoparticle synthesis; microbial-assisted nanoparticle synthesis; renewable precursors in nanotechnology; low-toxicity nanomaterials; biological activities of green synthesized nanoparticles
(This special issue belongs to the Section Green Chemistry)
Tailored Fluorescent Probes for Selective Recognition of Heavy Metal Species
edited by
submission deadline 31 Dec 2025 | Viewed by 165
Keywords: fluorescent probes; heavy metal detection; selective recognition; multi-target sensing; environmental monitoring; bioimaging; food safety; sensor design
(This special issue belongs to the Section Analytical Chemistry)
Advances in Heterogeneous Catalysis for Green Chemistry
edited by Chen Li, and
submission deadline 31 Dec 2025 | Viewed by 163
Keywords: green chemistry; heterogeneous catalysis; photocatalysis; electrocatalysis; thermal catalysis
(This special issue belongs to the Section Green Chemistry)
Advances in Material Chemistry for Sustainable Energy Storage: Innovations, Challenges, and Future Directions
edited by and Peng Liu
submission deadline 31 Dec 2025 | Viewed by 155
Keywords: phase change thermal energy storage material; energy storage hydrogel materials; materials for photocatalytic hydrogen production; thermochemical heat storage materials; electrochemical energy storage material
(This special issue belongs to the Section Materials Chemistry)
Metal Oxide Nanomaterials: Synthesis, Structures and Optical Properties
edited by
submission deadline 31 Dec 2025 | Viewed by 134
Keywords: metal oxide; nanomaterial; synthesis; structure; optical; electric; property; application; catalyst; photodegradation; solar cell; sensor; vector; drug delivery; nanomedicine; green technology; optical communication; metal doping; photocatalysis; band-gap engineering; defect characterization and engineering; biosensor; antibacterial
(This special issue belongs to the Section Nanochemistry)
Emerging Technologies for Chemical Recovery of Spent Batteries
edited by Yuan Liang and
submission deadline 31 Dec 2025 | Viewed by 88
Keywords: spent battery recycling; chemical recycling technologies; critical metal recovery; hydrometallurgy; bioleaching; circular economy
(This special issue belongs to the Section Green Chemistry)
Degradation of Soil Pollutants
edited by
submission deadline 31 Dec 2025 | Viewed by 83
Keywords: degradation; remediation; analysis; pollutions; soil; new technology
(This special issue belongs to the Section Applied Chemistry)
Review Papers in Materials Chemistry—2nd Edition submission deadline 15 Jan 2026 | 1 articles | Viewed by 696 | Submission Open
Keywords: materials chemistry; organic and inorganic materials; biomaterials; nanomaterials; hybrid materials; core-shell materials; thin films; self-assembling systems; tailored and unusual properties of materials
(This special issue belongs to the Section Materials Chemistry)
Transition Metal Complexes with Bioactive Ligands
edited by
submission deadline 16 Jan 2026 | 1 articles | Viewed by 1214 | Submission Open
Keywords: transition metal complexes; DFT; QTAIM; biological activity; bioactive ligands; crystal structures
(This special issue belongs to the Section Organometallic Chemistry)
Isolation, Analysis, and Biological Activities of Secondary Metabolites Derived from Plants
edited by , Mindaugas Liaudanskas and
submission deadline 20 Jan 2026 | 5 articles | Viewed by 7812 | Submission Open
Keywords: isolation; analysis; phytochemical composition; biological activity
(This special issue belongs to the Section Natural Products Chemistry)
Advanced Polymer Composites for Sustainable Technologies: Synthesis, Characterization, and Performance
edited by Fujuan Liu
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1227 | Submission Open
Keywords: sustainable polymer composites; thermal insulation materials; fiber-reinforced composites; renewable energy applications; biodegradable composites; flexible electronics; light-emitting materials; Janus membrane design; nanomaterials; biomimetic design
(This special issue belongs to the Section Macromolecular Chemistry)
The Design, Synthesis, and Biological Activity of New Drug Candidates, 2nd Edition
edited by Carolina S. Marques, and
submission deadline 30 Jan 2026 | 4 articles | Viewed by 5255 | Submission Open
Keywords: bioactive; in silico; in vitro; in vivo; ADMET; synthesis; privilege scaffold; active pharmaceutical ingredients
(This special issue belongs to the Section Medicinal Chemistry)
Molecular, Technological and Nutritional Aspects of Food Fortification and Processing submission deadline 30 Jan 2026 | 1 articles | Viewed by 1921 | Submission Open
Keywords: food fortification and processing; molecular; technological; and nutritional aspects; food composition; functionality; nutritional quality
(This special issue belongs to the Section Food Chemistry)
The Application of LC-MS in Pharmaceutical Analysis—2nd Edition
edited by Wing Lam and
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1845 | Submission Open
Keywords: LC– MS; chemical characterization; metabolite identification; metabolomics; pharmacokinetics
(This special issue belongs to the Section Analytical Chemistry)
State of the Art of Natural Antioxidants: Extraction, Detection and Biofunctions—2nd Edition submission deadline 30 Jan 2026 | 1 articles | Viewed by 1626 | Submission Open
Keywords: antioxidant; phytochemistry; bioactive molecules; biotechnology; biomolecules; analytical chemistry; food chemistry; phytomedicine
(This special issue belongs to the Section Natural Products Chemistry)
Phosphorus-Based Compounds in Medicinal Chemistry
edited by
submission deadline 30 Jan 2026 | Viewed by 300 | Submission Open
Keywords: phosphorus-containing drugs; prodrugs; phosphonates; phosphinates; bioisosteres; enzyme inhibitors; drug design; drug discovery
(This special issue belongs to the Section Medicinal Chemistry)
Phytochemicals as Promising Molecules in Acute and Chronic Neurodegeneration
edited by
submission deadline 30 Jan 2026 | Viewed by 206 | Submission Open
Keywords: phytochemicals; nutrients; morphology; transmission electron microscopy; autophagy; proteasome; neurodegeneration; central nervous system; peripheral nervous system; sensory organs
(This special issue belongs to the Section Natural Products Chemistry)
Advances in Nanoscale Drug Delivery Technologies and Theranostics
edited by and Valérie Maraval
submission deadline 30 Jan 2026 | Viewed by 149 | Submission Open
Keywords: drug delivery; theranostics; nanoparticles; dendrimers; nanovesicle; nanomicelles; polymers; nanomaterials
(This special issue belongs to the Section Nanochemistry)
Advanced Functional Quantum Dots: Design, Properties and Application submission deadline 30 Jan 2026 | Viewed by 102 | Submission Open
Keywords: quantum dots; functionalization; quantum modelling; novel materials; nanomaterials
(This special issue belongs to the Section Nanochemistry)
Health Benefits and Applications of Bioactive Phenolic Compounds submission deadline 31 Jan 2026 | 5 articles | Viewed by 22541 | Submission Open
Keywords: natural bioactive compounds; health benefits; bioactive properties; extraction methodologies; in vitro and in vivo studies; potential applications
(This special issue belongs to the Section Natural Products Chemistry)
Organosulfur and Organoselenium Chemistry II
edited by Ming Wang
submission deadline 31 Jan 2026 | 6 articles | Viewed by 22518 | Submission Open
Keywords: organosulfur; organoselenium; synthesis; transformation; application
(This special issue belongs to the Section Organic Chemistry)
Recent Advances in Natural Compounds Research: Chemistry, Biology and Biotechnology submission deadline 31 Jan 2026 | 7 articles | Viewed by 21001 | Submission Open
Keywords: bioactive constituents; phytoextract; biological activity
(This special issue belongs to the Section Natural Products Chemistry)
Design and Mechanisms of Photo(electro)catalysts for Water Splitting
edited by Zhaohui Zhou, Jiafeng Geng and
submission deadline 31 Jan 2026 | 3 articles | Viewed by 15777 | Submission Open
Keywords: photocatalysis; electrocatalysis; photoelectrocatalysis; photo(electro)catalysts synthesis; water splitting; hydrogen production; renewable fuels
(This special issue belongs to the Section Applied Chemistry)
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