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Recent Advances in Natural Compounds Research: Chemistry, Biology and Biotechnology

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 2311

Special Issue Editors


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Guest Editor
Council for Agricultural Research and Economics (CREA)—Research Center for Olive, Fruit and Citrus Crops, Corso Savoia 190, 95024 Acireale, Italy
Interests: citrus bioactive compounds; recovery of high value compounds from fruit processing wastes; mild food processing; quality of foods; traceability of organic food productions
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Fruit and Vegetable Product Technology, Prof. Wacław Dąbrowski Institute of Agricultural and Food Biotechnology, Rakowiecka 36, 02-532 Warsaw, Poland
Interests: fruits; vegetables; emerging techniques; food processing and preservation; bioaccessibility and bioavailability; high-pressure processing; high-pressure homogenization; high-pressure carbon dioxide; ultrasounds; microwaves; food chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The number of studies on natural compounds is increasing due to rising interest in finding novel alternatives to synthetic and/or artificial compounds for use in the chemical, phytochemical, nutraceutical, cosmetic and pharmaceutical industries. In addition, new formulations proposed as food supplements are increasingly using natural compounds due to their greater appeal among consumers who are convinced of their health benefits. Based on this, several research studies have examined the discovery of bioactive ingredients from natural matrices, covering the latest findings about new extraction techniques, the chemical characterization of phytoextracts with valuable biological activity, and in vivo tests and in vitro bioassays to determine the biological activity of purified compounds. However, there is a further need to explore the chemistry, biology and biotechnology behind the use of natural compounds in order to ensure they are being used safely. Therefore, this Special Issue of Molecules is dedicated to original research and review articles that cover the latest findings about the structures and chemical characteristics of natural compounds, their biological mechanisms of action, their in vitro and in vivo bioavailability, their actual and future biotechnological applications, and the advantages, drawbacks and opportunities of their use in diverse feasible fields of application. In vitro and in vivo toxicological studies jointly associated with the chemical and biological characterizations of natural compounds are also welcome.

Dr. Simona Fabroni
Dr. Krystian Marszałek
Dr. Aldo Todaro
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive constituents
  • phytoextract
  • biological activity

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Published Papers (3 papers)

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Research

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23 pages, 3343 KiB  
Article
Mucoadhesive PVA Film for Sustained Resveratrol Delivery: Formulation, Characterization, and Release Profile
by Arleta Dołowacka-Jóźwiak, Izabela Nawrot-Hadzik, Adam Matkowski, Tomasz Ciecieląg, Agnieszka Gawin-Mikołajewicz, Ruth Dudek-Wicher, Mirosława Prochoń, Dorota Markowska, Robert Adamski, Adrian Wiater and Bożena Lucyna Karolewicz
Molecules 2025, 30(12), 2642; https://doi.org/10.3390/molecules30122642 - 18 Jun 2025
Viewed by 311
Abstract
This study aimed to develop and optimize polyvinyl alcohol (PVA)-based polymeric films containing resveratrol (RSV) and to evaluate their applicability as oral mucosal wound dressings. Given the dynamic and complex nature of the oral environment, physicochemical parameters such as elasticity, mucoadhesive strength, and [...] Read more.
This study aimed to develop and optimize polyvinyl alcohol (PVA)-based polymeric films containing resveratrol (RSV) and to evaluate their applicability as oral mucosal wound dressings. Given the dynamic and complex nature of the oral environment, physicochemical parameters such as elasticity, mucoadhesive strength, and the release profile of the RSV were systematically investigated. The therapeutic performance of pure resveratrol was compared with that of an extract derived from Reynoutria japonica. Films were fabricated using a solvent casting method and characterized in terms of thickness uniformity, weight, color consistency, and flexibility, all of which met the required pharmaceutical criteria. Two tested formulations, FR2 (RSV/PVA/PVP/MCA15C/NaCMC/W/PGE), FE2 (extract/PVA/PVP/MCA15C/NaCMC/W/PGE), showed the best mucoadhesive properties (261.11 ± 0.5 g for FR2 and 299.43 ± 0.38 g for FE2) and a favorable release profile both in water (72.42% for FR2, 77.23% for FE2) and in saliva (49.74% for FR2, 49.70% for FE2). Moreover, the optimized films are characterized by hydrophilicity (contact angle < 90°) and the pH value of the extract after their blurring is close to physiological, which promotes better tolerance and reduces the risk of irritation. Obtained results for polymeric films with resveratrol and R. japonica extract confirmed their great potential for use in dentistry as modern, mucoadhesive dressings, improving the effectiveness of local therapies. Full article
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Review

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33 pages, 1830 KiB  
Review
Eleutherococcus senticosus (Acanthopanax senticosus): An Important Adaptogenic Plant
by Grzegorz Kos, Katarzyna Czarnek, Ilona Sadok, Agnieszka Krzyszczak-Turczyn, Paweł Kubica, Karolina Fila, Gizem Emre, Małgorzata Tatarczak-Michalewska, Małgorzata Latalska, Eliza Blicharska, Daniel Załuski, Nazım Şekeroğlu and Agnieszka Szopa
Molecules 2025, 30(12), 2512; https://doi.org/10.3390/molecules30122512 - 8 Jun 2025
Viewed by 1181
Abstract
This comprehensive review focuses on Eleutherococcus senticosus (ES), examining the phytochemical composition, traditional medicinal roles, ecological traits, and pharmacological effects. Native to Northeast Asia, ES is used in traditional Chinese, Korean, and Japanese medicine. The rhizomes and bark are utilized medicinally and valued [...] Read more.
This comprehensive review focuses on Eleutherococcus senticosus (ES), examining the phytochemical composition, traditional medicinal roles, ecological traits, and pharmacological effects. Native to Northeast Asia, ES is used in traditional Chinese, Korean, and Japanese medicine. The rhizomes and bark are utilized medicinally and valued for their adaptogenic properties that enhance stress resistance, boost mental and physical endurance, and exhibit immunostimulatory effects that strengthen the immune system. Its pharmacological potential stems from a variety of bioactive compounds, including eleutherosides, lignans, saponins, flavonoids, and polysaccharides, which contribute to health benefits such as neuroprotective, antidiabetic, anticancer, and antioxidative activities. Neuroprotective properties may aid in the management of neurodegenerative conditions, such as Alzheimer’s and Parkinson’s disease, while antidiabetic effects support glucose regulation and insulin sensitivity. With increasing demands and conservation concerns, sustainable cultivation practices are essential, as ES is endangered in some areas. Plant biotechnology techniques offer solutions to enhance secondary metabolite yields while ensuring genetic stability and minimizing environmental impacts. ES is a promising natural resource for various industries because of its extensive benefits. Still, its conservation and sustainable production are critical and require ongoing research and innovative cultivation strategies. Full article
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17 pages, 4068 KiB  
Review
Functional Approaches to Discover New Compounds via Enzymatic Modification: Predicted Data Mining Approach and Biotransformation-Guided Purification
by Te-Sheng Chang
Molecules 2025, 30(10), 2228; https://doi.org/10.3390/molecules30102228 - 20 May 2025
Viewed by 424
Abstract
In the field of biotechnology, natural compounds isolated from medicinal plants are highly valued; however, their discovery, purification, biofunctional characterization, and biochemical validation have historically involved time-consuming and laborious processes. Two innovative approaches have emerged to more efficiently discover new bioactive substances: the [...] Read more.
In the field of biotechnology, natural compounds isolated from medicinal plants are highly valued; however, their discovery, purification, biofunctional characterization, and biochemical validation have historically involved time-consuming and laborious processes. Two innovative approaches have emerged to more efficiently discover new bioactive substances: the predicted data mining approach (PDMA) and biotransformation-guided purification (BGP). The PDMA is a computational method that predicts biotransformation potential, identifying potential substrates for specific enzymes from numerous candidate compounds to generate new compounds. BGP combines enzymatic biotransformation with traditional purification techniques to directly identify and isolate biotransformed products from crude extract fractions. This review examines recent research employing BGP or the PDMA for novel compound discovery. This research demonstrates that both approaches effectively allow for the discovery of novel bioactive molecules from natural sources, the enhancement of the bioactivity and solubility of existing compounds, and the development of alternatives to traditional methods. These findings highlight the potential of integrating traditional medicinal knowledge with modern enzymatic and computational tools to advance drug discovery and development. Full article
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