Phosphorus-Based Compounds in Medicinal Chemistry
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 January 2026 | Viewed by 54
Special Issue Editor
Interests: phosphinic acid derivatives; enzyme inhibitors; organic synthesis; bioactive modified peptides; drug delivery systems; small molecular weight enzyme inhibitors; produgs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Phosphorus-based compounds have emerged as a significant class of therapeutic agents in medicinal chemistry, owing to their unique structural and functional attributes. These compounds can be categorized into various classes, including phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, and phosphoric anhydrides. Each class exhibits distinct chemical properties that can be leveraged for specific therapeutic applications. Phosphonates and phosphinates are often utilized as stable analogs of phosphate groups, enhancing the metabolic stability of drug candidates. Similarly, α-aminophosphonates and α-aminophosphinates have demonstrated remarkable potential as inhibitors of enzymes like aminopeptidases and proteases. Their structural resemblance to natural amino acids allows them to interfere with enzymatic pathways, offering therapeutic avenues for managing diseases such as hypertension and cancer. The special issue titled "Phosphorus-based Compounds in Medicinal Chemistry" aims to explore the latest advancements in the design, synthesis, and application of these compounds. It will highlight their role in developing novel therapeutics, emphasizing structure-activity relationships, biological evaluations, and potential clinical applications.
Dr. Magdalini Matziari
Guest Editor
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Keywords
- phosphorus-containing drugs
- prodrugs
- phosphonates
- phosphinates
- bioisosteres
- enzyme inhibitors
- drug design
- drug discovery
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