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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Alternative Routes for the Delivery of Drug Molecules
edited by , and Teodora Popova
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2015 | Submission Open
Keywords: transdermal; nasal; pulmonary; ophthalmic; liposomes; dendrimers; microneedles; cubosomes
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Environmental Remediation and Wind–Sand Stabilization Materials
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1891 | Submission Open
Keywords: soil remediation and improvement; water purification; windbreak and sand fixation; air purification materials; natural eco-materials
(This special issue belongs to the Section Applied Chemistry)
Recent Advances in the Development of Innovative Anticancer Agents and Antitumor Strategies submission deadline 28 Feb 2027 | 2 articles | Viewed by 1864 | Submission Open
Keywords: anticancer strategies; anticancer agents; drug design; drug development; chemical synthesis; small molecules; drug delivery; prodrugs; hybrid compounds; multitarget ligands; conjugate derivatives; polypharmacology; hybrid nanoassemblies; nanoparticles; supramolecular systems; theranostics
(This special issue belongs to the Section Medicinal Chemistry)
Novel Functional Nanomaterials for Energy, Environmental and Sensing Applications
edited by , Ming Li and Miao Cheng
submission deadline 28 Feb 2027 | 3 articles | Viewed by 1827 | Submission Open
Keywords: gas sensor and device; fluorescence probe; environmental catalysis; environmental monitoring; hydrogen production and safety; energy storage materials
(This special issue belongs to the Section Materials Chemistry)
Ionic Liquids and Deep Eutectic Solvents: From Synthesis to Emerging Applications
edited by Marina Cvjetko Bubalo and
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1825 | Submission Open
Keywords: microwave-assisted organic synthesis; biotransformation; green chemistry; ionic liquids; antioxidant activity; phenolic compounds; reactor design; cytotoxicity; environmental engineering; green technology
(This special issue belongs to the Section Green Chemistry)
Bioactive Compounds in Olive Oil: Biosynthesis, Transformations, and Health Effects submission deadline 28 Feb 2027 | 1 articles | Viewed by 1723 | Submission Open
Keywords: virgin olive oil; olive oil bioactives; volatile compounds and aroma profile; biosynthesis and transformation of olive oil bioactives; olive oil production and processing chain; oxidative stability and antioxidant activity; sensory quality attributes; bioavailability and health-related effects
(This special issue belongs to the Section Food Chemistry)
Anticancer, Antioxidant, and Anti-Inflammatory Activities of Natural Products, Second Edition
edited by
submission deadline 28 Feb 2027 | 3 articles | Viewed by 1692 | Submission Open
Keywords: natural products; anticancer; antioxidant; anti-inflammatory; plant extracts; derived compounds; oxidative stress
(This special issue belongs to the Section Natural Products Chemistry)
Nanomaterial-Based Sensors for Food Safety Analysis
edited by and
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1679 | Submission Open
Keywords: nanomaterial-based sensors; electrochemical/optical sensors; pathogen/toxin/pesticide/heavy metal ion detection; point-of-care testing; on-site; all-in-one; sensitivity enhancement
(This special issue belongs to the Section Nanochemistry)
Porous Carbon Materials: Preparation and Application, 2nd Edition
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1676 | Submission Open
Keywords: porous carbon materials; energy storage; environmental science; sensors; adsorption; catalysis
(This special issue belongs to the Section Applied Chemistry)
Fluorescent Molecular Tools for Neuroscience Research
edited by Sheng Xie
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1671 | Submission Open
Keywords: histochemical method; fluorescent probes; brain-wide 3D imaging; neuropathology; immunofluorescence labeling; transgenic labeling; small-fluorophore labeling; metallophilic labeling; virus-based labeling
(This special issue belongs to the Section Cross-Field Chemistry)
Therapeutic Potential of Bioactive Dietary Small Molecules and Natural Products: From Discovery to Mechanistic Understanding submission deadline 28 Feb 2027 | 1 articles | Viewed by 1578 | Submission Open
Keywords: bioactive compounds; natural products; dietary small molecules; therapeutic agents; mechanism of action; nutraceuticals; functional foods; molecular targets; pharmacological activity; chronic diseases; anti-inflammatory; antioxidant; metabolic disorders; hormone-related diseases
(This special issue belongs to the Section Food Chemistry)
Novel Analytical Techniques in Food Chemistry
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1446 | Submission Open
Keywords: food quality and safety; food authenticity; food analysis; mass spectrometry; spectroscopic techniques; biosensors; chemometrics and machine learning; foodomics
(This special issue belongs to the Section Analytical Chemistry)
Molecular Conformational Diversity submission deadline 28 Feb 2027 | 1 articles | Viewed by 1366 | Submission Open
Keywords: conformational diversity; conformational ensemble; conformational flexibility; conformational sampling; energy landscape; protein dynamics; structural heterogeneity; intrinsically disordered proteins; molecular recognition; ligand binding; protein–protein interactions
(This special issue belongs to the Section Chemical Biology)
Organic Luminescent Materials: Synthesis, Mechanism, and Applications
edited by Xiaonan Ma and Jianyu Zhang
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1322 | Submission Open
Keywords: organic luminescent materials; molecular design; chemical synthesis; photophysics; excited-state dynamics; OLED displaying; bio-imaging; sensing
(This special issue belongs to the Section Materials Chemistry)
Advances in the Chemical Analysis of Prehistoric Materials
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1321 | Submission Open
Keywords: archaeological tools (resins, adhesives); chromatography (gas chromatography); infrared spectroscopy; nuclear magnetic resonance (NMR); archaeobotany; archaeology; terpenoids; sesquiterpenes; volatile organic compounds (VOCs)
(This special issue belongs to the Section Analytical Chemistry)
Aroma and Volatile Compounds from Foods
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1225 | Submission Open
Keywords: aroma compounds; volatile organic compounds (VOCs); food flavor; gas chromatography–mass spectrometry (GC-MS); odor activity value (OAV); food quality; food processing; sensory analysis
(This special issue belongs to the Section Flavours and Fragrances)
Design, Synthesis, and Photochemical Studies of Functional Dyes
edited by Liang Han
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1205 | Submission Open
Keywords: synthesis of functional dyes; photochemistry of dyes; organic dyes; functional organic dyes; photo-inducing materials; organic photoelectric materials
(This special issue belongs to the Section Photochemistry)
Bioactive Molecules from Natural Sources and Their Functions—2nd Edition
edited by Sonia Del Prete and
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1186 | Submission Open
Keywords: secondary metabolites; primary metabolism; living organisms; function; structure; enzymes; biosynthetic pathways
(This special issue belongs to the Section Medicinal Chemistry)
Chemical Transformations and Analysis in Food: Nutrition, Flavor Compounds, and Microbiological Research submission deadline 28 Feb 2027 | 1 articles | Viewed by 1144 | Submission Open
Keywords: flavor compounds; fermented food; flavor formation; flavor compound production/synthesis
(This special issue belongs to the Section Food Chemistry)
Topological Polymers for Advanced Materials
edited by , and Jiatao Yan
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1096 | Submission Open
Keywords: dendritic macromolecules; molecular brushes; polymer brushes; comb-like polymers; star polymers; graft polymers; polyrotaxanes; 2D polymers
(This special issue belongs to the Section Materials Chemistry)
Biomass and Waste Conversion and Valorization to Chemicals, Energy and Fuels, 2nd Edition
edited by José A.P. Coelho and Roumiana P. Stateva
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1094 | Submission Open
Keywords: plants and microalgal biomass; sustainable waste valorization; biofuels; biorefinery, neoteric solvents
(This special issue belongs to the Section Green Chemistry)
Photocatalytic Water Splitting: Cutting-Edge Research and Future Directions
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1083 | Submission Open
Keywords: photocatalytic water splitting; hydrogen production; photocatalysts; heterojunctions; co-catalysts; charge carrier
(This special issue belongs to the Section Photochemistry)
Porphyrin-Based Molecules: From Synthesis to Structure–Activity Relationships and Applications
edited by Prashanth K. Poddutoori
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1064 | Submission Open
Keywords: porphyrin; phthalocyanine; corrole; borondipyrromethane; synthesis; photophysics; electrochemistry; energy transfer; electron transfer; solar energy conversion; photodynamic therapy; molecular electronics, photonics, and catalysis
(This special issue belongs to the Section Organic Chemistry)
Secondary Metabolites: Green Isolation, AI-Assisted Elucidation, and Mechanistic Insight
edited by Niko Radulović and
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1054 | Submission Open
Keywords: secondary metabolites; natural products; AI/ML dereplication; metabolomics; advanced NMR/MS; green/flow isolation; chemoproteomics; mechanism of action; FAIR data
(This special issue belongs to the Section Natural Products Chemistry)
Biosynthetic Strategies for Exploiting Natural Products: Recent Advances and Applications
edited by and
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1042 | Submission Open
Keywords: biosynthetic gene clusters; genome mining; heterologous expression; pathway elucidation; metabolic engineering
(This special issue belongs to the Section Natural Products Chemistry)
Metal–Organic Framework-Based Materials: Preparation and Application in Electrochemistry
edited by and
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1017 | Submission Open
Keywords: metal–organic frameworks; energy storage/conversion; electrocatalysis; electrochemical sensors; flexible devices
(This special issue belongs to the Section Materials Chemistry)
Carbohydrate-Based Drug Delivery Systems: Chemistry, Design, and Therapeutic Potential
edited by , and Paraskevi Papakyriakopoulou
submission deadline 28 Feb 2027 | 1 articles | Viewed by 998 | Submission Open
Keywords: carbohydrate-based drug delivery systems; polysaccharides; cyclodextrins; drug loading and release; routes of administration; in vitro–in vivo evaluation; PK/PD studies
(This special issue belongs to the Section Macromolecular Chemistry)
Advances in Supramolecular Systems for Biomolecular Recognition
edited by Liping Cao and
submission deadline 28 Feb 2027 | 2 articles | Viewed by 891 | Submission Open
Keywords: supramolecular systems; biomolecular recognition; host-guest interactions; molecular sensors; drug delivery; molecular scaffolds; biomolecular diagnostics; therapeutic applications
(This special issue belongs to the Section Molecular Structure)
Ligands: Design, Syntheses, and Applications in Organometallic Catalysis
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 868 | Submission Open
Keywords: ligand design; organometallic catalysis; green & sustainable chemistry; industrial catalysis; synthesis & applications
(This special issue belongs to the Section Organometallic Chemistry)
Effects of Functional Foods and Dietary Bioactives on Human Health—2nd Edition
edited by and
submission deadline 28 Feb 2027 | 2 articles | Viewed by 846 | Submission Open
Keywords: functional foods; dietary bioactives; nutraceuticals; molecular nutrition; bioavailability; gut microbiome; multi-omics; metabolomics; polysaccharides; polyphenols; peptides; inflammation; oxidative stress; chronic disease prevention; precision nutrition; translational nutrition; sustainable bioactives
(This special issue belongs to the Section Food Chemistry)
Small Molecules for Gonadal Diseases
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 805 | Submission Open
Keywords: small molecules; gonadal diseases; polycystic ovary syndrome; testicular dysfunction; prostate diseases; oxidative stress; inflammation; reproductive biology
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacological Evaluation and Phytochemical Analysis of Natural Products, 2nd Edition submission deadline 28 Feb 2027 | 1 articles | Viewed by 779 | Submission Open
Keywords: natural products; phytochemistry; pharmacological evaluation; secondary metabolites; phytochemical analysis
(This special issue belongs to the Section Natural Products Chemistry)
Quinoline and Quinazoline Derivatives: A Valuable Prospect for Drug Discovery
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 670 | Submission Open
Keywords: quinoline; isoquinoline; quinolone; quinazoline; quinazolinone; biological evaluation; chemotherapeutic molecules; anticancer activity
(This special issue belongs to the Section Medicinal Chemistry)
Design and Biological Applications of Platinum-Based Complexes
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 643 | Submission Open
Keywords: photoactivatable Pt(II) complexes; Pt(IV) prodrugs; multi-nuclear and supramolecular platinum complexes; antimicrobial and antibiofilm platinum agents; platinum theranostics
(This special issue belongs to the Section Inorganic Chemistry)
Antioxidant and Anti-Inflammatory Activities of Plant Extracts
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 633 | Submission Open
Keywords: plant extracts; antioxidant activity; anti-inflammatory activity; secondary metabolites; metabolomics; Nrf2–Keap1 pathway; NF-κB signaling; oxidative stress (ROS/RNS); structure–activity relationship (SAR); multi-omics profiling
(This special issue belongs to the Section Natural Products Chemistry)
Advanced Materials for Tissue Engineering and Drug Delivery
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 631 | Submission Open
Keywords: tissue repair and regeneration; bone and cartilage reconstruction; drug delivery; wound healing; design; synthesis; characterization; application; biopolymer-based and composite scaffolds; hard and soft tissue engineering; 3D-printed and bioprinted constructs; surface-functionalized biomaterials; smart and stimuli-responsive materials; nanoparticle-based drug delivery and gene delivery systems; hydrogels for cell encapsulation and controlled release; in vitro and in vivo evaluation of biocompatibility and efficacy
(This special issue belongs to the Section Materials Chemistry)
High-Value Utilization of Food and Agricultural By-Products submission deadline 28 Feb 2027 | 1 articles | Viewed by 578 | Submission Open
Keywords: food by-products; agro-industrial by-products; waste valorization; bioactive compounds; sustainable processing; value-added products; biotechnology; circular economy; zero-waste strategy
(This special issue belongs to the Section Food Chemistry)
Advances in Target-Based Drug Design, Discovery and Screening
edited by Guang Huang
submission deadline 28 Feb 2027 | Viewed by 576 | Submission Open
Keywords: structure-based drug design; synthesis; target-based drug discovery; virtual screening; inhibitors; PROTACs; degraders; kinases; epigenetic targets
(This special issue belongs to the Section Medicinal Chemistry)
New Nanomaterials for Diagnostics and Drug Delivery, 2nd Edition submission deadline 28 Feb 2027 | 1 articles | Viewed by 513 | Submission Open
Keywords: nanomaterials; drug delivery; diagnostic; nano-formulations; 3D printing
(This special issue belongs to the Section Applied Chemistry)
Design and Application of Nanomaterials for Photocatalytic Degradation
edited by Aleksandra R. Zarubica and Radomir B. Ljupković
submission deadline 28 Feb 2027 | 1 articles | Viewed by 502 | Submission Open
Keywords: nanomaterials design; nanomaterial photocatalysts; nanomaterials synthesis; photocatalysis; environmental pollution; photodegradation; material characterization
(This special issue belongs to the Section Nanochemistry)
Research and Application of Plant Sourced Polysaccharides—3rd Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 454 | Submission Open
Keywords: polysaccharide; characterization; structure; physiochemical properties; functional activity
(This special issue belongs to the Section Natural Products Chemistry)
Bioactive Compounds and Phytochemical Diversity as Quality Traits in Horticultural Crops submission deadline 28 Feb 2027 | 1 articles | Viewed by 446 | Submission Open
Keywords: bioactive compounds; phytochemical diversity; phytochemical profiling; horticultural crops; natural products chemistry; plant secondary metabolites; metabolomics; analytical characterization; antioxidant activity; quality traits
(This special issue belongs to the Section Natural Products Chemistry)
Biocatalysis in Deep Eutectic Solvents: Stability, Immobilization and Applications submission deadline 28 Feb 2027 | Viewed by 435 | Submission Open
Keywords: biocatalysis; deep eutectic solvents; enzyme stability; enzyme selectivity; enzyme immobilization; reaction medium; enzymatic reactors; enzyme molecular dynamics
(This special issue belongs to the Section Green Chemistry)
Molecular Docking, Molecular Dynamics and Antiparasitic Evaluations of Natural Products
edited by and Márcia Machado Marinho
submission deadline 28 Feb 2027 | Viewed by 415 | Submission Open
Keywords: natural products; molecular docking; molecular dynamics; antiprotozoal; virtual screening; drug discovery
(This special issue belongs to the Section Natural Products Chemistry)
Transition-Metal-Catalyzed Cross-Coupling: From Classical Methods to Modern Advances submission deadline 28 Feb 2027 | Viewed by 412 | Submission Open
Keywords: cross-coupling; transition-metal catalysis; palladium catalysis; earth-abundant metals; nickel catalysis; copper catalysis; cobalt catalysis; iron catalysis; gold catalysis; ligand design
(This special issue belongs to the Section Organometallic Chemistry)
Lipid Oxidation and Flavor in Foods submission deadline 28 Feb 2027 | Viewed by 409 | Submission Open
Keywords: lipid oxidation; food flavor; bioactive compounds in food
(This special issue belongs to the Section Food Chemistry)
New Horizons in Drug Repurposing submission deadline 28 Feb 2027 | Viewed by 383 | Submission Open
Keywords: drug discovery; drug repositioning; drug repurposing; genetic diseases; rare diseases; cancer; orphan drugs
(This special issue belongs to the Section Medicinal Chemistry)
Phytochemicals in Medicinal Plants: From Extraction to Bioactivity submission deadline 28 Feb 2027 | Viewed by 382 | Submission Open
Keywords: medicinal plants; phytochemicals; bioactive compounds; extraction strategies; phytochemical profiling; biological activities; health applications; nutraceuticals
(This special issue belongs to the Section Natural Products Chemistry)
Advanced Structured Catalysts for Sustainable Chemical Transformations submission deadline 28 Feb 2027 | Viewed by 376 | Submission Open
Keywords: structured catalysts; sustainability; porous materials; CO2 utilization; CO2 valorization; biomass conversion; green chemical processes; structure–catalytic performance relationships; shaped catalysts; photocatalysis; electrocatalysis
(This special issue belongs to the Section Green Chemistry)
Metal Complexes: Synthesis, Characterization and Reactivity
edited by Sibel Demir Kanmazalp and
submission deadline 28 Feb 2027 | Viewed by 367 | Submission Open
Keywords: metal complexes; coordination chemistry; synthesis; X-ray diffraction; DFT; molecular docking; catalysis; medicinal chemistry; biological activity
(This special issue belongs to the Section Inorganic Chemistry)
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