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Ionic Liquids and Deep Eutectic Solvents: From Synthesis to Emerging Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 729

Special Issue Editors


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Guest Editor
Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Interests: microwave-assisted organic synthesis; biotransformation; green chemistry; ionic liquids; antioxidant activity; phenolic compounds; reactor design; cytotoxicity; environmental engineering; green technology
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Guest Editor
Department of Biochemistry and Molecular Biology “B” and Immunology, Faculty of Chemistry, University of Murcia, Murcia, Spain
Interests: biocatalysis in Ionic liquids; supercritical fluid technologies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In numerous industrial processes, significant amounts of volatile and flammable organic solvents are utilized in various reaction systems and separation steps, heavily influencing both the environmental and economic performance of these processes. For instance, the chemical industry consumes over 20 million tons of organic solvents annually, contributing to greenhouse gas emissions and posing risks of explosions and health hazards. Consequently, an expanding field of research in the realm of green chemistry focuses on creating new, environmentally friendly, and adaptable solvents that satisfy both technological and economic requirements.

Among the proposed solvents, ionic liquids (ILs) and deep eutectic solvents (DESs) have garnered significant attention due to their negligible vapor pressure, high thermal stability, and tunable properties, making them ideal for various applications. A state-of-the-art analysis shows their consistent growth in the fields of chemical synthesis and catalysis, extraction and separation processes, electrochemistry and energy storage, food technology, and life sciences.

This Special Issue will delve into the latest research and developments in IL- and DES-assisted technologies, evaluating their potential to transform industrial processes and meet future environmental and economic challenges.

Prof. Dr. Marina Cvjetko Bubalo
Prof. Dr. Pedro Lozano
Guest Editor

Manuscript Submission Information

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Keywords

  • microwave-assisted organic synthesis
  • biotransformation
  • green chemistry
  • ionic liquids
  • antioxidant activity
  • phenolic compounds
  • reactor design
  • cytotoxicity
  • environmental engineering
  • green technology

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Published Papers (1 paper)

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Research

13 pages, 2032 KB  
Article
Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents
by Chiara Falcini, David Jaén-Herrera, Rosario Fernández, Andrés R. Alcántara and Gonzalo de Gonzalo
Molecules 2026, 31(4), 745; https://doi.org/10.3390/molecules31040745 - 22 Feb 2026
Viewed by 492
Abstract
The use of Type III Deep Eutectic Solvents (DESs) as both solvents and cocatalysts enable the one-pot synthesis of several β-ketosulfides, structural motifs commonly found in biologically active compounds, via a multicomponent reaction (MCR) involving 2-bromoketones, alkyl or benzyl halides, and potassium thioacetate [...] Read more.
The use of Type III Deep Eutectic Solvents (DESs) as both solvents and cocatalysts enable the one-pot synthesis of several β-ketosulfides, structural motifs commonly found in biologically active compounds, via a multicomponent reaction (MCR) involving 2-bromoketones, alkyl or benzyl halides, and potassium thioacetate in basic medium. Under these conditions, it was possible to avoid not only the use of the non-eco-friendly solvent dimethylformamide (DMF), but also an additional hydrolytic step previously reported for the preparation of these molecules. The MCR conducted in the presence of the DES ChCl:Gly (1:2) was optimized through the evaluation of different reaction parameters. Notably, the non-conventional medium could be recycled up to four times without any appreciable loss of catalytic activity. Environmental metrics, including the E factor, E+ factor, and Global Warming Potential (GWP), were calculated for the process both in the presence and absence of the DES, demonstrating improved environmental performance when the DES was employed. Full article
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