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Anticancer, Antioxidant, and Anti-Inflammatory Activities of Natural Products, Second Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 28 February 2027 | Viewed by 1323

Editor


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Guest Editor
Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria
Interests: antitumor therapy; drug delivery; nanocarriers; tumor resistance models; metal complexes; lipid-based nanoparticles; liposomes; niosomes; natural antitumor compounds; neuroprotection; neurodegenerative diseases
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Special Issue Information

Dear Colleagues,

This Special Issue aims to publish high-quality research and comprehensive reviews on the anticancer, antioxidant, and anti-inflammatory activities of natural products. We seek contributions that advance our understanding of bioactive compounds from natural sources - including plants, fungi, marine organisms, and microorganisms, with demonstrated efficacy in modulating molecular pathways relevant to cancer, oxidative stress, and inflammation.

The focus is on rigorously characterized compounds and extracts, mechanistic studies (both in vitro and in vivo), and translational research that bridges basic discoveries to applications. Papers elucidating interactions between phytochemicals and molecular targets, synergistic or antagonistic effects in complex extracts, and comparative studies versus synthetic agents are also welcome.

Oxidative stress and inflammation are closely linked to the pathogenesis of numerous chronic conditions, including cancer, neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s), cardiovascular diseases, and metabolic syndromes. We invite original research and critical reviews that comprehensively address the preventive and therapeutic potential of natural products in these contexts.

Key areas include, but are not limited to:

  • Isolation, characterization, and synthesis of bioactive natural compounds with demonstrated anticancer, antioxidant, or anti-inflammatory properties.
  • Molecular mechanisms of action underpinning observed biological effects.
  • Modulation of cellular signaling pathways, redox homeostasis, and gene expression by natural products.
  • Integrated omics approaches, systems biology, and network pharmacology applied to natural product research.
  • Evaluation of safety, toxicity, and efficacy in cellular and animal models.
  • Novel formulations and delivery systems enhancing bioavailability and targeting.
  • Traditional medicine approaches supported by modern analytical validation.

Dr. Rositsa Mihaylova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • anticancer
  • antioxidant
  • anti-inflammatory
  • plant extracts
  • derived compounds
  • oxidative stress

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Related Special Issue

Published Papers (2 papers)

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Research

13 pages, 3691 KB  
Article
Vialinin A Inhibits Microtubule-Mediated Secretory Granule Transport for Degranulation in RBL-2H3 Cells by Targeting the PI3K/Akt Axis
by Ange Murielle Djidjou Tagne, Kotoe Ishii, Yasukiyo Yoshioka, Kouichi Sugaya, Jun-ichi Onose, Shunsuke Yajima and Naoki Abe
Molecules 2026, 31(16), 2825; https://doi.org/10.3390/molecules31162825 - 13 Aug 2026
Viewed by 139
Abstract
The bioregulatory function of food-derived bioactive factors in complementary therapies for lifestyle-related diseases is attracting worldwide attention. Vialinin A, a p-terphenyl compound isolated from the edible Chinese mushroom Thelephora vialis, inhibits the production and release of tumor necrosis factor α and [...] Read more.
The bioregulatory function of food-derived bioactive factors in complementary therapies for lifestyle-related diseases is attracting worldwide attention. Vialinin A, a p-terphenyl compound isolated from the edible Chinese mushroom Thelephora vialis, inhibits the production and release of tumor necrosis factor α and Syk kinase activity, a key protein involved in the development of allergic rhinitis. However, its effect on other calcium-independent signaling molecules remains unclear. This study investigated the effects of vialinin A on microtubule formation signaling pathways in RBL-2H3 cells. The results showed that vialinin A inhibited Fyn kinase activity and reduced PI3K (class IA) phosphorylation in a dose-dependent manner. Notably, vialinin A inhibited PI3Kδ kinase activity and reduces Akt phosphorylation even at low concentrations. These findings suggest that vialinin A suppresses microtubule formation and granule translocation required for mast cell degranulation through inhibition of the Fyn–PI3K–Akt signaling pathway. Collectively, vialinin A may represent a promising lead compound for the development of anti-allergic therapeutics. Full article
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15 pages, 4365 KB  
Article
A Simple Method for Isolating Fucoxanthin, Which Shows a Wide Range of Physiological Effects, from Microalga, Chaetoceros calcitrans
by Akari Numase, Rei Ohtsu, Kiyohiko Suzuki and Yoshinori Kawazoe
Molecules 2026, 31(10), 1707; https://doi.org/10.3390/molecules31101707 - 18 May 2026
Viewed by 638
Abstract
Fucoxanthin is a carotenoid belonging to the xanthophyll family and has been shown to exhibit various physiological activities. While brown algae have traditionally been used as a source of fucoxanthin, microalgae have been attracting attention as an alternative source to brown algae in [...] Read more.
Fucoxanthin is a carotenoid belonging to the xanthophyll family and has been shown to exhibit various physiological activities. While brown algae have traditionally been used as a source of fucoxanthin, microalgae have been attracting attention as an alternative source to brown algae in recent years. Although various methods have been devised to isolate fucoxanthin from microalgae, these methods have drawbacks such as requiring special equipment or being unsuitable for large-scale production. Therefore, we tried to develop a simple method that anyone can easily try and that allows for mass production. First, the extraction yields using various solvents were compared. Acetone showed the most efficient extraction yield for short extraction times, but as the extraction time increased, there was almost no difference in the extraction yields among methanol, ethanol, and acetone. Compared to ethanol, methanol had an extraction efficiency of approximately 98%, while acetone had an extraction efficiency of 90%. Then, our efforts have resulted in the development of a method that can isolate fucoxanthin with a purity of over 90% with just a single run of a silica gel column chromatography. Furthermore, the fucoxanthin with this method retained a wide range of physiological activities, including antioxidant, anti-cancer, and anti-inflammatory effects. Our findings might broaden the scope of fucoxanthin research and contribute to process development of fucoxanthin. Full article
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