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Porphyrin-Based Molecules: From Synthesis to Structure–Activity Relationships and Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 30 August 2026 | Viewed by 674

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Department of Chemistry & Biochemistry, University of Minnesota Duluth, 1038 University Drive, Duluth, MN 55812, USA
Interests: porphyrin chemistry; organic-inorganic hybrid materials; solar energy harvesting applications; molecular electronic; photonic and sensor devices; cancer detection and treatment applications
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Special Issue Information

Dear Colleagues,

Polypyrrolic derivatives, including porphyrins, phthalocyanines, corroles, dipyrromethane and their related compounds, have played a vital role in supramolecular chemistry for various applications, such as artificial photosynthesis, molecular sensors, molecular electronics and photonics, molecular catalysis, and photodynamic therapy. These varied applications originate from these derivatives’ adaptable structural and tunable optical and redox properties. Additionally, as tetradentate ligands, they can accommodate varied metal and non-metal ions in their cavity. This ability further enhances demand for them in many research areas. Due to these photo and redox properties, many impressive porphyrin-based supramolecular systems have been reported in porphyrin chemistry. Although various porphyrins and their related derivatives have been reported in recent decades, the design and construction of new kinds with unique structures and optical properties remain two of the most important frontier research topics in supramolecular chemistry.

This Special Issue will collect high-quality original research and incisive reviews that showcase the latest achievements and future perspectives in porphyrin science, covering topics such as the following:

  • Novel synthetic methodologies and green approaches for porphyrins and porphyrinoids;
  • Structure–activity relationships linking substitution pattern, metal center, and supramolecular assembly to photophysical and catalytic performance;
  • Porphyrin-based materials for energy conversion and storage (photocatalysis, solar cells) and for sensing/optical devices;
  • Biomedical applications including photodynamic therapy, imaging, and theranostics;
  • Computational and mechanistic studies that guide rational design;
  • Hierarchical assemblies, surface/integrated devices, and hybrid materials;
  • Porphyrin-based hybrid materials for molecular catalysis;
  • Fundamental aspects of polypyrrolic compounds.

By bringing together cutting-edge contributions in synthesis, characterization, theory, and application, this Special Issue will highlight the central role of porphyrin-based molecules in addressing contemporary scientific and technological challenges, as well as identify clear routes for future interdisciplinary research. We welcome submissions of original research articles, comprehensive reviews, and communications that align with these themes.

You may choose our Joint Special Issue in Chemistry.

Dr. Prashanth K. Poddutoori
Guest Editor

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Keywords

  • porphyrin
  • phthalocyanine
  • corrole
  • borondipyrromethane
  • synthesis
  • photophysics
  • electrochemistry
  • energy transfer
  • electron transfer
  • solar energy conversion
  • photodynamic therapy
  • molecular electronics, photonics, and catalysis

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Published Papers (1 paper)

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Research

16 pages, 2878 KB  
Article
Synthesis and Intramolecular Charge Transfer Studies on meso-Tetracyanobutadine-Functionalized Diphenylporphyrin Complexes Incorporating Copper and Nickel Metals
by Sumit Kumar Yadav, Jatan K. Sharma, Muniappan Sankar and Francis D’Souza
Molecules 2026, 31(6), 934; https://doi.org/10.3390/molecules31060934 - 11 Mar 2026
Viewed by 444
Abstract
This study presents the synthesis and electrochemical characterization of meso-tetracyanobutadiene (TCBD)-functionalized diphenylporphyrin (DPP) complexes incorporating copper (Cu) and nickel (Ni) metals. These push–pull metallo diphenylporphyrin–TCBD complexes were synthesized via a [2 + 2] cycloaddition–retroelectrocyclization reaction between 5-bromo-15-formyl-10,20-diphenylporphyrin metal(II) complexes (M = Cu, [...] Read more.
This study presents the synthesis and electrochemical characterization of meso-tetracyanobutadiene (TCBD)-functionalized diphenylporphyrin (DPP) complexes incorporating copper (Cu) and nickel (Ni) metals. These push–pull metallo diphenylporphyrin–TCBD complexes were synthesized via a [2 + 2] cycloaddition–retroelectrocyclization reaction between 5-bromo-15-formyl-10,20-diphenylporphyrin metal(II) complexes (M = Cu, Ni) and tributyl(phenylethynyl)stannate, followed by tetracyanoethylene (TCNE) addition. The resulting TCBD-functionalized porphyrins were obtained in moderate yields (70–75%) and thoroughly characterized by 1H and 13C NMR, UV-Vis spectroscopy, MALDI-TOF-MS, and single-crystal XRD. Although the single-crystal X-ray structure of NiDPP was solved, DFT calculations were used to determine the structures of the donor–acceptor MDPP-TCBD systems and to visualize their electronic structures. HOMO on the porphyrin π system and LUMO on the TCBD entity were observed, and energy level diagrams clearly laid out the electron donor and acceptor parts of the molecular systems. As expected, these novel donor–acceptor porphyrinoid assemblies exhibited enhanced push–pull properties in both the ground and excited states. Femtosecond transient absorption studies revealed that both NiDPP-TCBD and CuDPP-TCBD populate the charge-transfer state upon photoexcitation, with lifetimes of 383.1 ps and 484.7 ps, respectively, in benzonitrile. The charge-transfer states populated the triplet or doublet states (in the case of CuDPP) before returning to the ground state. Full article
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