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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Development in Fermented Products—Third Edition submission deadline 20 Dec 2025 | 3 articles | Viewed by 7147 | Submission Open
Keywords: application of microorganisms to the production of fermented food; traditional and innovative fermentation technologies; natural health benefits of fermented foods; homemade and industrial fermented products; identification and production of novel starter cultures of commercial interest; microbial biotransformation and production of active metabolites; mechanisms of action of fermented food on the microbiota
(This special issue belongs to the Section Natural Products Chemistry)
Macromolecules, Particles, and Colloids in Ionic Liquids: Structure, Stability, and Function
edited by Qi Han, Zhengfei Chen and
submission deadline 20 Dec 2025 | Viewed by 217 | Submission Open
Keywords: ionic liquids; macromolecules; colloids; self-assembly; nanoparticles; green solvents; soft matter
(This special issue belongs to the Section Molecular Liquids)
Design and Synthesis of Molecular Systems to Prepare Conductive Materials
edited by , and Tomoyuki Akutagawa
submission deadline 20 Dec 2025 | Viewed by 169 | Submission Open
Keywords: single-molecule conductance; quantum tunneling; molecular conductor; single crystal; charge transport; charge transfer complex; thin film; self-assembled monolayer; mesoscale conductor; polymer
(This special issue belongs to the Section Materials Chemistry)
Bioactive Compounds in Foods, Beverages, and By-Products and Their Functional Potential submission deadline 28 Dec 2025 | 1 articles | Viewed by 857 | Submission Open
Keywords: bioactive compounds in foods; beverages; and/or food by-products; unconventional raw materials as a source of bioactive compounds; bioactive compounds in human health and diseases; bioactive compounds: focus on its mechanism of action; bioavailability of the bioactive compounds; studies (in silico; in vitro; vivo; and clinical) with a focus on bioactive potential; analytical techniques to identify bioactive compounds; trends and advances in bioactive compounds analysis
(This special issue belongs to the Section Food Chemistry)
Porphyrin-Based Compounds: Synthesis and Application, 2nd Edition submission deadline 30 Dec 2025 | 7 articles | Viewed by 12086 | Submission Open
Keywords: synthesis of porphyrins and derivatives; functionalization/structural modification of porphyrinoids; structural and photophysical characterization; porphyrinic functional materials; biomedical applications optoelectronic applications; porphyrin– protein interactions
(This special issue belongs to the Section Organic Chemistry)
Nanomaterials for Catalytic Upcycling/Conversion of Plastics/Biomass
edited by Lei Huang, Xiang Wang and Zhili Li
submission deadline 30 Dec 2025 | 2 articles | Viewed by 5716 | Submission Open
Keywords: plastic waste; upcycling; conversion; biomass conversion; biomass upgrading; lignin depolymerization; nanocatalysis; thermal catalysis
(This special issue belongs to the Section Nanochemistry)
Opportunities and Challenges in Organic Optoelectronic Materials submission deadline 30 Dec 2025 | 2 articles | Viewed by 3088 | Submission Open
Keywords: organic semiconductors; organic photonics; inorganic/organic hybrid materials; excitons; electroluminescence; photovoltaics; vacuum/solution process; energy transfer
(This special issue belongs to the Section Materials Chemistry)
Advanced Nanotherapeutics: Design, Synthesis and Applications—2nd Edition submission deadline 30 Dec 2025 | 2 articles | Viewed by 2980 | Submission Open
Keywords: nanomedicine; nanodelivery systems; polymer therapeutics; polymer nanoparticles; anticancer nanomaterials; antimicrobial nanoparticles; theranostics
(This special issue belongs to the Section Nanochemistry)
Small-Molecule Targeted Drugs
edited by and Annoor Awadasseid
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1510 | Submission Open
Keywords: drug discovery; high-throughput screening; structure (ligand)-based drug design; PD-1/PD-L1 drug design; molecular docking; pharmacophore modeling; therapeutics; computational approaches
(This special issue belongs to the Section Medicinal Chemistry)
Essential Oils and Their Multifaceted Studies: From Extraction to Applications submission deadline 30 Dec 2025 | Viewed by 187 | Submission Open
Keywords: in silico; in vivo; in vitro; agriculture; food science; medicinal; pharmacological
(This special issue belongs to the Section Food Chemistry)
Exploring the Potential of Biodegradable and Biocompatible Natural Polymers
edited by and Dingfeng Xu
submission deadline 30 Dec 2025 | Viewed by 186 | Submission Open
Keywords: natural polymers; biopolymers; biocompatibility; material design; biomedical applications; packaging; derivatives; environmental impact
(This special issue belongs to the Section Applied Chemistry)
Covalent Organic Frameworks for Photocatalysis or Fluorescence Detection
edited by and Bing Han
submission deadline 30 Dec 2025 | Viewed by 121 | Submission Open
Keywords: covalent organic framework (COF); photocatalysis; water splitting; CO2 reduction; H2O2 production; fluorescence detection
(This special issue belongs to the Section Photochemistry)
Heterocycles in Medicinal Chemistry III
edited by
submission deadline 31 Dec 2025 | 12 articles | Viewed by 42404 | Submission Open
Keywords: drugs; heterocycles; pharmacophore; drug design; computer study; synthesis; analysis; natural compounds; carbohydrates; physicochemical properties; ADMET; biological screening; chemical biology; biological chemistry; biomaterials
(This special issue belongs to the Section Medicinal Chemistry)
Phytochemicals from Diet and Medicinal Plants: Chemical Diversity, Delivery Systems and Bioactivity
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 41973 | Submission Open
Keywords: phytochemicals; chemical structure; chemical modification; synthesis; delivery systems; bioactivities; metabolism
(This special issue belongs to the Section Natural Products Chemistry)
Bioactive Phenolic and Polyphenolic Compounds, 3rd Edition
edited by
submission deadline 31 Dec 2025 | 14 articles | Viewed by 37828 | Submission Open
Keywords: food chemistry; natural products; antioxidants; polyphenols; chromatography; spectroscopy; mass spectrometry; extraction; biological activity; sensors
(This special issue belongs to the Section Natural Products Chemistry)
Advances in Density Functional Theory (DFT) Calculation submission deadline 31 Dec 2025 | 13 articles | Viewed by 36008 | Submission Open
Keywords: DFT; theoretical and computational chemistry; new functional materials; calculations of new materials and catalysts; characterization of the catalytic materials; non-covalent interactions (NCI); biological activities; electronic proprieties; kinetics and catalysis; QTAIM
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Research on Heterogeneous Catalysis—2nd Edition
edited by and
submission deadline 31 Dec 2025 | 20 articles | Viewed by 33090 | Submission Open
Keywords: heterogeneous; catalysis; catalyst; surface; reaction
(This special issue belongs to the Section Applied Chemistry)
Natural Antioxidants in Functional Food submission deadline 31 Dec 2025 | 7 articles | Viewed by 28454 | Submission Open
Keywords: natural antioxidants; bioactive compounds; functional foods; novel foods; exotic foods; health and nutrition claims
(This special issue belongs to the Section Food Chemistry)
Functional Molecules as Novel Cosmetic Ingredients
edited by Jing Wang and Zhong Liu
submission deadline 31 Dec 2025 | 9 articles | Viewed by 26186 | Submission Open
Keywords: synthetic molecules; plant extracts; natural compounds; biotech-derived molecules; natural-derived molecules; fermentation-derived ingredients; biological activity; cosmetics; encapsulation and delivery technologies of ingredients; skin-care; hair-care
(This special issue belongs to the Section Natural Products Chemistry)
Feature Papers in Food Chemistry—3rd Edition submission deadline 31 Dec 2025 | 10 articles | Viewed by 25359 | Submission Open
Keywords: food chemistry; functional food; ingredients; bioactivity; antioxidants; food safety and health; food processing
(This special issue belongs to the Section Food Chemistry)
Metal Complexes as Potential Antimicrobial and Antiproliferative Agents
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 25348 | Submission Open
Keywords: metal complexes; antimicrobial activity; antiproliferative activity; cytotoxicity; biofilm
(This special issue belongs to the Section Inorganic Chemistry)
Applied Chemistry in Asia
edited by
submission deadline 31 Dec 2025 | 14 articles | Viewed by 20292 | Submission Open
Keywords: applied chemistry; new molecules and natural materials; solar energy and photo-electro-catalysis; analytical methods and techniques; electrochemistry and energy; biodegradable materials and medicines; environment and green chemistry
(This special issue belongs to the Section Applied Chemistry)
Probing Pharmacological and Biological Performance of Synthetic and Natural Compounds—2nd Edition
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 19532 | Submission Open
Keywords: natural and synthetic compounds; aging; cancer; cardiovascular diseases; metabolic syndromes; inflammation; oxidative stress; regulated cell death
(This special issue belongs to the Section Natural Products Chemistry)
Current Development of Asymmetric Catalysis and Synthesis
edited by
submission deadline 31 Dec 2025 | 8 articles | Viewed by 18781 | Submission Open
Keywords: asymmetric synthesis; asymmetric catalysis; transition metal-catalyzed asymmetric catalysis and synthesis; organocatalyzed asymmetric catalysis and synthesis; enzyme-catalyzed catalysis and synthesis; kinetic resolution; theoretical investigations into asymmetric catalysis and synthesis
(This special issue belongs to the Section Organic Chemistry)
Computational Insights into Protein Engineering and Molecular Design
edited by Jianpeng Ma and Gang Xu
submission deadline 31 Dec 2025 | 6 articles | Viewed by 18749 | Submission Open
Keywords: protein engineering; protein design; protein structure prediction; computational molecular docking; drug design; optimizing small molecules; molecular dynamic simulation
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Exclusive Contributions by the Editorial Board Members (EBMs) of the Organic Chemistry Section of Molecules
edited by
submission deadline 31 Dec 2025 | 12 articles | Viewed by 18633 | Submission Open
Keywords: organic compounds; organic synthesis; organic reaction; click chemistry; organocatalysis
(This special issue belongs to the Section Organic Chemistry)
Drug Delivery Systems Based on Polysaccharides: Second Edition submission deadline 31 Dec 2025 | 4 articles | Viewed by 18046 | Submission Open
Keywords: polysaccharides; polysaccharide derivatives; hydrogels; micro- and nanoparticles (spheres and capsules); hybrid nanoparticles; functionalized nanoparticles for drug targeting; micelles based on amphiphilic polysaccharides; drug delivery
(This special issue belongs to the Section Macromolecular Chemistry)
An Insight into Medicinal Chemistry of Anticancer Drugs
edited by Gabriela Figueroa-González and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 17972 | Submission Open
Keywords: natural products; anticancer; synthesis; drug resistance; multitargeted therapy
(This special issue belongs to the Section Medicinal Chemistry)
Bioactive Compounds and Small Molecules with Neuroprotective and Anti-Inflammatory Functions
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 16328 | Submission Open
Keywords: bioactive foods; small molecules; neuroprotection; anti-inflammatory; inflammasome; neurodegeneration
(This special issue belongs to the Section Natural Products Chemistry)
Recent Advances in Computer-Aided Drug Design and Drug Discovery
edited by Jinping Lei and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 15820 | Submission Open
Keywords: computer-aided drug design; structure-based drug design; ligand-based drug design; fragment-based drug design; pharmacophore; QSAR; molecular modelling; artificial intelligence
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Recent Trends of Functional Nanomaterials for Biomedical and Healthcare Applications (2nd Edition) submission deadline 31 Dec 2025 | 6 articles | Viewed by 15302 | Submission Open
Keywords: nanomaterials; implants and wearable devices; drug delivery and therapeutic efficacy; biosensors and bioelectronics; biocompatible and toxicity; bio-imaging and diagnostics; healthcare devices; theranostic platforms
(This special issue belongs to the Section Inorganic Chemistry)
Heterocyclic Compounds: Synthesis, Application and Theoretical Study
edited by
submission deadline 31 Dec 2025 | 8 articles | Viewed by 14831 | Submission Open
Keywords: synthesis and transformation of heterocycles; structural chemistry; reaction mechanisms; stereochemistry; regiochemistry; quantum chemical computations; biological activity of heterocyclic compounds; green chemistry
(This special issue belongs to the Section Organic Chemistry)
Photochemistry in Asia
edited by
submission deadline 31 Dec 2025 | 10 articles | Viewed by 14282 | Submission Open
Keywords: photochemistry; photophysics; photocatalysts; synthetic photochemistry; photoelectrochemistry; computational photochemistry; luminescent molecular sensors; nanomaterials; electron transfer; energy transfer
(This special issue belongs to the Section Photochemistry)
Synthesis of Bioactive Compounds, 3rd Edition
edited by
submission deadline 31 Dec 2025 | 11 articles | Viewed by 13996 | Submission Open
Keywords: biological activity; nature-derived molecules; heterocyclic moieties; aromatic species; structural diversity; alkaloids; organic synthesis
(This special issue belongs to the Section Organic Chemistry)
Multifunctional Nanomaterials for Bioapplications, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 13783 | Submission Open
Keywords: composite nano-materials; multifunctional nano-materials; imaging; biosensor; drug loading; antitumor; antibacterial; regeneration; PDT; PTT
(This special issue belongs to the Section Medicinal Chemistry)
Functional Nanomaterials for Biosensors and Biomedicine Application
edited by and Xiaoqiang Liu
submission deadline 31 Dec 2025 | 5 articles | Viewed by 13458 | Submission Open
Keywords: functional nanomaterials; biosensors; biomedicine; drug delivery; biotherapy
(This special issue belongs to the Section Applied Chemistry)
Cutting-Edge Progress in Natural Product-Derived Antimicrobial Drugs submission deadline 31 Dec 2025 | 3 articles | Viewed by 12982 | Submission Open
Keywords: natural products; structural elucidation; bio-activity guided isolation; pathogen; antimicrobial
(This special issue belongs to the Section Natural Products Chemistry)
Bioactive Compounds from Natural Sources: Discovery, Evaluation and Applications, 2nd Edition submission deadline 31 Dec 2025 | 6 articles | Viewed by 12104 | Submission Open
Keywords: bioactive compound; natural product; isolation; synthesis; structural elucidation; bioactivity evaluation
(This special issue belongs to the Section Natural Products Chemistry)
Porous Organic Materials: Design and Applications: Volume II
edited by and Qi Chen
submission deadline 31 Dec 2025 | 7 articles | Viewed by 11368 | Submission Open
Keywords: topology design; synthesis; structure— function correlation; adsorption and separation; catalysis; energy storage and conversion; mass transportation; biological application
(This special issue belongs to the Section Materials Chemistry)
Chromatography and Spectrometry in Food Safety and Pharmaceutical Analysis submission deadline 31 Dec 2025 | 4 articles | Viewed by 11312 | Submission Open
Keywords: pharmaceutical analysis; chromatography; HPLC; TLC; GC; food quality control; bioactive compounds; spectrometry; QSAR; QSPR
(This special issue belongs to the Section Analytical Chemistry)
Role of Natural Products in Inflammation submission deadline 31 Dec 2025 | 6 articles | Viewed by 10854 | Submission Open
Keywords: inflammation; natural compounds; terrestrial plants; marine plants; NF-kB; hemoxygenase and cyclooxygenase pathways
(This special issue belongs to the Section Natural Products Chemistry)
Natural Products as New Antiviral/Antiparasitic/Antibacterial/Antimicrobial Treatment Options submission deadline 31 Dec 2025 | 5 articles | Viewed by 10768 | Submission Open
Keywords: natural products; antiviral compounds; antiparasitic agents; antibacterial properties; antimicrobial activity; drug-resistant pathogens; plant-derived compounds; microbial sources; terpenoids; alkaloids; phenols; flavonoids; antimicrobial peptides
(This special issue belongs to the Section Natural Products Chemistry)
Biological Activities of Traditional Medicinal Plants, 2nd Edition submission deadline 31 Dec 2025 | 6 articles | Viewed by 10520 | Submission Open
Keywords: traditional medicinal plants; ethnobotany; bioactive compounds; extraction strategies; phytochemical profiling; biological activities; health applications; nutraceuticals
(This special issue belongs to the Section Natural Products Chemistry)
Exclusive Feature Papers in Synthetic Medicinal Chemistry submission deadline 31 Dec 2025 | 4 articles | Viewed by 10291 | Submission Open
Keywords: antitumor activity; antibacterial activity; natural and synthetic compounds
(This special issue belongs to the Section Organic Chemistry)
Phytochemicals as Valuable Tools for Fighting Metabolic Disorders
edited by Anna Ramunno and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 10105 | Submission Open
Keywords: phytochemicals; metabolic disorders; obesity; diabetes; antioxidants; therapeutic applications
(This special issue belongs to the Section Natural Products Chemistry)
New Insight into Edible Oil: From Food Chemistry to Health Benefits submission deadline 31 Dec 2025 | 4 articles | Viewed by 9854 | Submission Open
Keywords: edible oils; fats; structured lipids; bioactive compounds; quality; stability; degradation; contamination
(This special issue belongs to the Section Food Chemistry)
Phytochemical Profiling, Bioactivity, Biotechnology Studies and Practical Applications of Medicinal and Cosmetic Plants submission deadline 31 Dec 2025 | 6 articles | Viewed by 9523 | Submission Open
Keywords: plant metabolites; plant biotechnology; bioactive natural compounds; natural products metabolomics; pharmacological activity of natural compounds; cosmetic applications of natural compounds; isolation of natural compounds; essential oils; biological activity of natural compounds; in vitro approach; in vivo approach; clinical investigations; ethnopharmacological indications; ethnobotanical indications; technology of cosmetic formulations; skin permeability; irritating potential; agricultural practices
(This special issue belongs to the Section Natural Products Chemistry)
Analysis and Biological Evaluation of Bioactive Compounds from Natural Sources, 2nd Edition
edited by Luana Pulvirenti and Rosanna Avola
submission deadline 31 Dec 2025 | 7 articles | Viewed by 9314 | Submission Open
Keywords: natural products; natural product chemistry; polyphenols; vegetable extract profiling; herbal medicine; phytochemicals; biological applications of natural products; mechanism of action
(This special issue belongs to the Section Natural Products Chemistry)
Characterization and Instrumental Analysis of Aroma-Active Compounds in Fermented Food and Beverage, the Second Edition
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 8905 | Submission Open
Keywords: fermentation; fermented food production; fermented food flavor; aroma characterization; gas chromatography– mass spectrometry/olfactory (GC-MS/O); Sensorial properties; HS-SPME; stir bar and thin-film sorptive extraction
(This special issue belongs to the Section Flavours and Fragrances)
Renewable Energy, Fuels and Chemicals from Biomass, 2nd Edition
edited by and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 8851 | Submission Open
Keywords: biomass conversion technologies; renewable energy; biofuel synthesis; catalytic biomass transformation; bioethanol; biodiesel; green/sustainable chemistry; biotechnological applications
(This special issue belongs to the Section Applied Chemistry)
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