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Bioactive Compounds and Small Molecules with Neuroprotective and Anti-Inflammatory Functions

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 216

Special Issue Editor


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Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy
Interests: extracellular vesicle; microglia; bioactive foods; neuroprotection; neurodegenerative diseases; ageing; anti-inflammatory molecules; curcumin; resveratrol; vitamins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Most neurodegenerative diseases are defined as complex multifactorial disorders, with genetic and environmental factors greatly contributing to their onset.

The relevance of lifestyle, including diet and exercise, has been associated with improved learning and memory capacity, delayed age-related cognitive decline, and a reduced risk of neurodegeneration.

The bioactive compounds and small molecules found in food exhibit beneficial effects, such as antioxidant, anti-inflammatory, and neuroprotective.

There is evidence that the consumption of certain food components, such as omega-3 fatty acids, carotenoids, flavonoids, polyphenols, etc., can reduce the risk of neurodegeneration and inflammatory diseases.

Supplementation with bioactive compounds is a valuable tool for strengthening neuroprotection and preventing inflammatory diseases. Therefore, there is increasing interest in identifying nutrients or dietary treatments that are neuroprotective and anti-inflammatory.

This Special Issue, entitled “Bioactive Compounds and Small Molecules with Neuroprotective and Anti-Inflammatory Functions”, welcomes the submission of both original research manuscripts and reviews concerning the in vitro and in vivo biological effects of bioactive foods and small molecules and their potential therapeutic applications in neuroprotection and inflammatory diseases.

Prof. Dr. Chiara Porro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive foods
  • small molecules
  • neuroprotection
  • anti-inflammatory
  • inflammasome
  • neurodegeneration

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Published Papers (1 paper)

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Review

29 pages, 1368 KiB  
Review
Specialized Pro-Resolving Lipid Mediators in Pulmonary Diseases: Molecular and Therapeutic Implications
by Ángel Ortega, Pablo Duran, Bermary Garrido, Alexander Manzano, Carolina Navarro, Aljadis Silva, Milagros Rojas, Juan Bautista De Sanctis, Danuta Radzioch, Diego Rivera-Porras, Carlos Silva Paredes and Valmore Bermúdez
Molecules 2025, 30(10), 2212; https://doi.org/10.3390/molecules30102212 - 19 May 2025
Abstract
Inflammatory lung diseases (ILDs) represent a global public health crisis characterized by escalating prevalence, significant morbidity, and substantial mortality. In response to the complex immunopathogenic mechanisms driving these conditions, novel pharmacological strategies targeting resolution pathways have emerged throughout the discovery of specialized pro-resolving [...] Read more.
Inflammatory lung diseases (ILDs) represent a global public health crisis characterized by escalating prevalence, significant morbidity, and substantial mortality. In response to the complex immunopathogenic mechanisms driving these conditions, novel pharmacological strategies targeting resolution pathways have emerged throughout the discovery of specialized pro-resolving lipid mediator (SPM; resolvins, maresins, and protectins) dysregulation across the ILD spectra, positioning these endogenous molecules as promising therapeutic candidates for modulating maladaptive inflammation and promoting tissue repair. Over the past decade, this paradigm has catalyzed extensive translational research into SPM-based interventions as precision therapeutics for respiratory inflammation. In asthma, they reduce mucus hypersecretion, bronchial hyperreactivity, and airway inflammation, with prenatal SPM exposure potentially lowering offspring disease risk. In COPD, SPMs attenuate amyloid A-driven inflammation, normalizing cytokine/chemokine imbalances and oxidative stress and mitigating COVID-19-associated cytokine storm, enhancing survival. This review synthesizes SPMs’ pharmacotherapeutic mechanisms in ILDs and evaluates current preclinical and clinical evidence. Full article
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