Role of Natural Products in Inflammation
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 2760
Special Issue Editor
Interests: natural products; pharmacology; immunology; rheumatoid arthritis; medicinal plants; antioxidants; biological models; new generations of drug delivery; functional food
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammation is a biological response of the immune system to infectious microorganisms, tissue injury, cell death, and physical, chemical or biological mediators in the body in order to preserve normal tissue homeostasis. Both the innate and adaptive immune responses as are involved in inflammatory processes. However, uncontrolled acute inflammation may become chronic, contributing to a variety of chronic inflammatory diseases. Long-term use of anti-inflammatory drugs have been shown to cause many adverse effects. Hence, replacing traditional anti-inflammatory drugs with natural compounds without toxic side effects and with good curative effects is an urgent issue to be solved in the clinical treatment of inflammation-related diseases. Natural products, which have more pharmacological activities and lower toxicity, can serve as potential resources to develop natural anti-inflammatory drugs. They include bioactive peptides, fatty acids, polysaccharides, flavonoids, polyphenols, alkaloids, terpenes, natural pigments, volatile oils, and quinones, either present in the system or isolated from marine or plant sources: namely, omega-3 polyunsaturated fatty acids, white willow bark, curcumin (tumeric), green tea, pycnogenol (maritime pine bark), and resveratrol. They mostly act by suppressing the NF-kB and cyclooxygenase pathways in order to inhibit leukocyte recruitment, but other pathways could also be important and should be studied. Compounds isolated from terrestrial and marine plants are still not sufficiently investigated concerning their use as therapies in diseases involving inflammation.
Dr. Katarína Bauerová
Guest Editor
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Keywords
- inflammation
- natural compounds
- terrestrial plants
- marine plants
- NF-kB
- hemoxygenase and cyclooxygenase pathways
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