Bioactive Compounds from Natural Sources: Discovery, Evaluation and Applications, 2nd Edition

Dear Colleagues,

Bioactive compounds from natural sources and related structural analogues are attracting particular attention for their possible therapeutic potential and medical applications, especially for cancer, cardiovascular diseases, and infectious diseases. Nevertheless, bioactive compounds from complex matrix sources also present a great challenge to discovery, isolation, characterization, evaluation, and application. Improved isolation techniques, analytical tools, genome mining, engineering strategies, and microbial culturing advances are addressing such challenges and opening up new opportunities. The aim of this Special Issue is to collect important contributions in the field of bioactive compounds from plants, microbes, and animals. It covers research topics, including the following:

1. The isolation, structural elucidation, synthesis, transformation, and chemical modification of bioactive compounds.
2. Applications of advanced analytical technologies to bioactive compounds, including NMR, LC-MS, HRMS, IR, microcrystal electron diffraction, metabolomics, the profiling of responses to bioactive molecules at the single-cell level, genome-mining-driven discovery of bioactive compounds and related structural analogues, and the application of advanced microbial culturing approaches to identify new bioactive compounds.
3. The potential therapeutic applications and mechanisms of natural and natural-derived bioactive compounds based on in vitro or in vivo experiments.

We encourage you to send research and review articles related to aspects relevant to this Special Issue topic. Bioactive evaluations of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.

Dr. Tao Liu
Dr. Clementina Manera
Dr. Francesca Gado
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• bioactive compound
• natural product
• isolation
• synthesis
• structural elucidation
• bioactivity evaluation

• Bioactive Compounds from Natural Sources: Discovery, Evaluation and Applications in Molecules (10 articles)