Steroids-II

Dear Colleagues,

Steroids are traditionally defined as a class of tetracyclic compounds possessing a sterane (cyclopentanoperhydrophenanthrene) carbon skeleton. Despite their common biosynthetic origin, they are characterized by extensive structural diversity. Steroids are extremely widespread in nature, and this class of natural compounds exhibits a range of potent and important biological activities. Owing to these factors, and their rigid structure consisting of four fused rings (three cyclohexane and one cyclopentane), steroids have proven to be desirable and challenging synthetic targets. Moreover, they serve as particularly useful model compounds for studying the stereochemistry of different reactions and the development of synthetic methods leading to more complex and unique structures.

This Special Issue is devoted to recent developments encompassing this important class of compounds, ranging in scope from total syntheses and new strategies towards steroid synthesis, elucidation of their biological activities and the potential for further medical applications, to the isolation and structure elucidation of novel natural steroids, as well as biosynthetic studies exploring their origin and metabolic pathways.

Prof. Dr. Rafal R. Sicinski
Guest Editor

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