Special Issue "Natural Products and Inflammation"
Deadline for manuscript submissions: closed (15 July 2016)
Prof. Dr. Norbert Latruffe
Université de Bourgogne, 21000 Dijon, France
Website | E-Mail
Interests: bio-active polyphenols; resveratrol; inflammation; bio-availability; cancer; pathologies prevention
Norbert Latruffe obtained his PhD 1977, and has been appointed in 1989 full Professor in Biochemistry at the University of Burgundy-Dijon France, and as head of the Laboratory of Molecular and Cellular Biology to 2006. Then, he was in charge of the team of Biochemistry of Metabolism and Nutrition in the INSERM research center, UMR 866 of Dijon until end of 2011. Since 2013 he is senior Professor at the laboratory of Biochemistry at the faculty of life science. In 1998 he launched a new challenge on the preventing role of vine polyphenols especially resveratrol, against age-related pathologies: cancer, inflammation cardiovascular. He was one of the first to explore resveratrol transport and metabolism (2004), its pro-apoptotic properties (2004), discovered a new resveratrol signalling pathway through micro RNA’s modulation (2010). In 2014 he showed a preventive effect of wine polyphenols towards colon cancer in mice model. He organized several and workshop on wine and health. Recently he served as editor or co-editor of «Molecules» two special issues: Natural products and inflammation (2016) and Improvement of resveratrol efficacy (2017). To date, he published near 170 international papers and has given more than invited 140 lectures. In 2017 he conducted the edition of a book deal on wine and mediterranean diet (EUD editor, Dijon). N. Latruffe is (or past) expert of several evaluation councils and is member of the orientation council of the prestigious UNESCO Chair «heritage and traditions of wine ». He also awarded several distinctions.
Inflammation (or inflammatory reaction) is the response to body aggression by a pathogen agent, an allergen, a toxic compound, a tissue lesion, etc. It can be a general phenomenon with fever, tiredness, or a local phenomenon with pain and edema. Inflammation is characterized by the production of various active signaling molecules, such as vaso-active amines (histamine/serotonin), prostaglandins, leukotriens, kininogens/kallikreins/kinins, complement factors, cytokines, and MMPs/TIMPs (Tissue Inhibitors of MetalloProteinases). All of the following pathologies present with a strong inflammatory component; infection, injury, vessels atherosclerosis, diabetes mellitus, obesity, cancer, osteo-arthritis, macular eyes degenerescence, demyelination and brain pathologies associated with aging. Inflammation is a complex response that involves among other interactions between activated lymphocytes, dendritic cells (i.e., antigen presenting cells or APCs) and monocytes, subsequently differentiated into macrophages. During this process, numerous cytokines are secreted by immune cells and by injured tissue non-immune cells as a consequence of cell-cell interactions.
The immunomodulation by various compounds, such as natural products, represents a promising preventive or therapeutic strategy against a number of pathological processes. Beside pro-inflammatory cytokines/interleukines, various lipid mediators produced through the arachidonate metabolism also play a key role in in inflammation-linked pathologies, such as atherosclerosis or cancers.
Original papers or review papers reporting the effect of natural products on inflammatory (anti- or pro-) processes are welcome. These compounds can include plant polyphenols, flavonoids or derivatives, lipid omega-6, marine compounds, bacterial extracts, etc.
Dr. Norbert Latruffe
Manuscript Submission Information
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- Natural products
- pro- and anti-inflammatory properties
- plant polyphenols
- marine products
- bacterial extracts