Dear Colleagues,

A popular definition of multicomponent reactions (MCRs) in the scientific community is: "MCRs are a convergent reaction class, in which three or more commercially available or simple molecules react to contribute significantly, with all or many of their atoms, to the final reaction product". MCRs proceed as a one-pot reaction through either a single reaction step or through sequential steps (without the need to replace the reaction medium), followed by a reaction cascade or equilibrium in which different atoms are assembled, leading to the final product.

MCRs have long been studied, such as the Strecker reaction in 1850 and the synthesis of dihydropyridines by Hantzsch in 1890, among others. However, it was early in this century that MCRs showed remarkable progress as a powerful and versatile tool for combatting modern synthesis challenges such as diversity-oriented synthesis (DOS), green chemistry, and combinatorial chemistry. In this context, different areas of organic synthesis have explored multicomponent reactions, with special emphasis on the development of compounds with a wide range of biological activities.

This Special Issue will present original research using MCRs or in which new MCRs will be developed.

Prof. Dr. Juan F. González
Guest Editor

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• multicomponent reactions
• sequential reactions
• synthetic strategies
• green chemistry
• chemical space
• diversity-oriented synthesis