Compounds Modulating Mitochondrial Ion Channels

Dear Colleagues,

This Special Issue will provide a critical overview of compounds modulating mitochondrial channels. In this Special Issue, the pharmacological properties of mitochondrial channels and their modulation by channel inhibitors and channel activators will be described. Recently, in mitochondrial membranes, a variety of channel proteins have been described. On top of the well-characterized porin channel in the outer mitochondrial membrane, a plethora of channel proteins were identified in the inner mitochondrial membranes. These include both anion-selective channels and cation-selective channels. The latter group is represented by calcium channels and potassium channels such as ATP, voltage-regulated, or calcium-activated potassium channels. The recent understanding of the molecular identity of mitochondrial permeability transition pore also leads to a new pharmacology of this protein. The main part of this Special Issue will describe the basic characteristics of each channel type mentioned above and its interaction with various molecules. Available channel modulators will be critically evaluated and rated by suitability for research and medical usage. Information on the potential side effects of these substances will be reported. Mitochondrial channel modulators will also be described in the physiological context of cytoprotection or cancer cell death. Thus, this Special Issue can be very useful for beginners in the field of mitochondrial channels.

Prof. Dr. Adam Szewczyk
Dr. Bogusz Kulawiak
Guest Editors

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