Special Issue "Counteracting Drug Resistant Mechanisms in Cancer"
Deadline for manuscript submissions: closed (15 January 2018)
Prof. Dr. M. Helena Vasconcelos
FFUP – Faculdade de Farmácia da Universidade do Porto, Porto 4050-313, Potugal; I3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal
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Interests: cancer drug resistance; cancer multidrug resistance; intercellular transfer of drug resistance mediated by Extracellular Vesicles (EVs); new approaches to overcome drug resistance; drug-efflux pumps; escape from apoptosis; autophagy; metabolic alterations associated with drug resistance; tumour-microenvironment interactions; cancer stem cells; microRNAs; biomarkers of minimal residual disease and of drug resistance
Drug resistance is a major obstacle to the successful treatment of cancer patients. The intratumor genetic heterogeneity and tumor dynamics, together with the presence of cancer stem cells, make it a very difficult problem to overcome. This Special Issue of Molecules aims to collect review and research articles on novel approaches for counteracting drug resistant mechanisms in cancer. Topics may include: i) novel compounds or small molecules designed to inhibit targets known to be responsible for chemoresistance (e.g. drug-efflux pumps or antiapoptotic proteins), ii) natural compounds that circumvent drug resistance, iii) molecules that target cancer stem cells, iv) antimiRs or siRNAs designed to inhibit targets responsible for chemoresistance, or v) drug delivery approaches to improve drug response.
Prof. Dr. M. Helena Vasconcelos
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- drug resistance
- multidrug resistance
- drug-efflux pumps
- ATP-binding cassette (ABC) transporters
- cell death
- apoptosis; autophagy
- DNA repair
- tumour-microenvironment interactions
- cancer stem cells
- natural products
- small molecules
- drug delivery
- extracellular vesicles