Analysis of Xenobiotics and Their Residues in Food, Biological and Environmental Samples by Chromatographic Techniques Coupled with Modern Detection Techniques (DAD, FLD, MS, MS/MS and Others) – Part 2

Dear Colleagues,

The challenge for the analyst is to develop effective and validated analytical strategies for the analysis of hundreds of different xenobiotics on hundreds of different sample types, quickly, accurately, and at acceptable cost. The most efficient approach to xenobiotic analysis involves the use of modern chromatographic methods. The following chromatographic methods are most frequently applied in environmental/biological samples and food analysis: high-performance liquid chromatography (HPLC), ultrahigh-performance liquid chromatography (UPLC), gas chromatography (GC), and multidimensional chromatographic techniques (GC x GC, LC x LC and others).

Xenobiotics can exert adverse effects on human health and increase the incidence of chronic diseases, including cancer, Parkinson’s, Alzheimer’s, multiple sclerosis, diabetes, cardiovascular, chronic kidney disease, and others. As a consequence, the development and validation of analytical methods for xenobiotics has become essential.

The choice of an appropriate extraction and analytical method for separation and final determination is closely related to the properties of the target compounds and matrices.

Common steps of sample treatment in most of the analytical methods reported for mixtures of xenobiotics and derivatives include sample pretreatment, extraction of analytes from the matrix, clean-up of the extracts to remove interferences, and concentration to achieve the desired sensitivity. Incontestable progress has been made during the past few years regarding the development of techniques for the preparation of samples for analysis, such as QuEChERS (quick, easy, cheap, effective, rugged, and safe), solid phase extraction (SPE), solid phase microextraction (SPME), stir bar sorptive extraction (SBSE), hallow-fiber liquid phase microextraction (HFLPME), dispersive liquid–liquid microextraction (DLLME) or focused ultrasonic solid–liquid extraction (FUSLE), and others.

I warmly invite our colleagues to submit their original contributions to this Special Issue in order to provide updates regarding chromatographic methods for xenobiotic analysis of food, biological and environmental samples that will be of interest to our readers.

I would be delighted if you could respond and upload papers by 31 December 2022 (deadline). I warmly invite colleagues to submit their original contributions to this Special Issue, which will be of interest to a wide range of our readers!

Prof. Dr. Tomasz Tuzimski
Guest Editor

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