Advances in Pharmacokinetics and Bioanalysis of Novel Drugs

Dear Colleagues,

In terms of treating complex diseases, such as malignant tumors, sudden infectious diseases, cardio-cerebrovascular diseases, and diabetes, the limitations of clinical treatment with single small-molecular chemical drug are obvious. In this case, a number of combination therapies (i.e., nanodrug formulation or macromolecular drugs) have attracted increasing interests. Furthermore, traditional medicines (i.e., traditional Chinese medicine (TCM)) are also bursting with elevated vitality for continuous innovation. However, nanodrugs, macromolecular drugs, and TCM have a shared characteristic, which is their complex and diverse compositions. As a result, they are facing difficulty in drug metabolism exploration and bioanalysis in vivo. With the continuous development of novel analytical technology, innovative materials, and AI technology, multiple novel bioanalytical methods and PK/PD prediction models for metabolic research on novel drugs in complex systems have emerged.

On this basis, we are planning this Special Issue of Molecules, titled “Advances in Pharmacokinetics and Bioanalysis of Novel Drugs”, that brings together research and review articles. The papers could be focused on, but not limited to, ADME characterization of novel drugs, screen reasonable PK/TK markers, multicomponent pharmacokinetic modeling, and novel methods and techniques for bioanalysis. We hope this issue will promote in-depth understanding on the pharmacokinetics and bioanalytical methods for novel drugs.

Dr. Caisheng Wu
Dr. Yingfei Li
Dr. Xiaoqiang Xiang
Guest Editors

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