New Strategies for Antimicrobial Treatment

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 179

Special Issue Editor


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Guest Editor
College of Pharmaceutical Sciences, Southwest University, Chongqing, China
Interests: metal-based novel antimicrobial agents and their targeted therapy

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to advancing the field of antimicrobial treatments by highlighting innovative strategies to counteract antimicrobial resistance. It aims to consolidate groundbreaking research on new antimicrobial agents, their unique mechanisms, and environmental implications. The Issue actively promotes interdisciplinary collaboration among microbiologists, pharmacologists, molecular biologists, and clinicians to hasten the transition of research findings into clinical applications. It seeks to widely disseminate cutting-edge findings to refine existing treatments and inspire the creation of novel therapeutic options. Contributions are invited on alternative therapies, resistance mechanisms, and combination therapies that enhance efficacy and minimize resistance development. The inclusion of diverse clinical trials and case studies will offer valuable insights into treatment effectiveness. Additionally, the Issue will emphasize the importance of pharmacokinetic and pharmacodynamic studies for personalized medicine and robust preclinical research to support clinical trials.

Dr. Chen Fu
Guest Editor

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Keywords

  • antimicrobial treatments
  • antimicrobial resistance
  • innovative strategies
  • new antimicrobial agents
  • clinical applications
  • alternative therapies
  • resistance mechanisms
  • combination therapies

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Published Papers (1 paper)

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Review

1602 KiB  
Review
Mechanisms Operating in the Use of Transition Metal Complexes to Combat Antimicrobial Resistance
by Shiming Wu, Meishu Wang, Ziyi Liu and Chen Fu
Microorganisms 2025, 13(7), 1570; https://doi.org/10.3390/microorganisms13071570 - 3 Jul 2025
Abstract
The increasing diversity and escalating drug resistance of bacterial pathogens have significantly compromised the efficacy of conventional antimicrobial agents, creating formidable challenges in modern infection control. These developments underscore the critical need for innovative therapeutic strategies to address the persistent global health burden [...] Read more.
The increasing diversity and escalating drug resistance of bacterial pathogens have significantly compromised the efficacy of conventional antimicrobial agents, creating formidable challenges in modern infection control. These developments underscore the critical need for innovative therapeutic strategies to address the persistent global health burden posed by microbial resistance. While metal-based compounds have been extensively studied for their anticancer properties in clinical applications, their potential in antimicrobial contexts remains relatively underexplored. This review systematically elaborates on the structure-activity relationship of metal complexes, with a focus on the unique characteristics of metal drugs that differ from organic small molecules. These drugs can overcome drug resistance through various mechanisms (such as generation of reactive oxygen species and penetration of biological membranes). Understanding these mechanisms provides a crucial basis for guiding ligand design and the development of delivery systems. Full article
(This article belongs to the Special Issue New Strategies for Antimicrobial Treatment)
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