Exploring Potential Diagnostic and Prognostic Salivary Biomarkers in Cancer

Dear Colleagues,

Recently, the attention of researchers to the study of human saliva as a biofluid with unique properties and diagnostic capabilities has increased. Indeed, a new term, “salivaomics”, has been proposed, which brings together knowledge about various components in saliva, including the genome, epigenome, transcript, proteome, metabolome, and microbiome. This has led to the development of new technologies and validation of a wide range of salivary biomarkers that will soon render saliva a valuable tool in clinical practice. Particular attention is paid to the search for new biomarkers and combinations of salivary biomarkers for the early diagnosis of cancer. Currently, the first steps are being taken towards evaluating the role of salivary biomarkers in the prognostic monitoring of cancer conditions. However, additional research investigations are required for the successful transfer of NMR-based salivary metabolomics to actual clinical use as a diagnostic benefit for clinicians, researchers, and patients alike. Therefore, this Special Issue is planned to include current research on the use of salivary biomarkers for the diagnosis and prognosis of cancer. Its major focus is to evaluate the future perspectives of reported observations acquired from metabolomics studies focused on evaluations of the diagnosis and prognostic tracking of salivary biomarkers for both oral and non-oral (systemic) cancers, the former including head and neck cancer, and oral cavity squamous cell and oropharyngeal squamous cell carcinomas, the latter featuring head and squamous cell, lung, breast, pancreatic and prostate cancers, among others.

Prof. Dr. Martin Grootveld
Dr. Lyudmila Bel'skaya
Guest Editors

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