Steroids in Non-alcoholic Fatty Liver Disease

Dear Colleagues,

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome affecting over 80% of patients with obesity and type 2 diabetes. It is a spectrum of disease ranging from simple steatosis to steatohepatitis, fibrosis, cirrhosis and significant risk of hepatocellular carcinoma (HCC). The pathophysiology is complex and incompletely understood, with the ‘multiple hit’ hypothesis considering multiple parallel insults to the liver. Steroids have a diverse array of functions and can have profound impacts on the different pathogenic processes.  

This Special Issue of Metabolites will publish original and review articles covering the role of steroid hormones and bile acids in the pathogenesis of NAFLD including inflammation, lipid and carbohydrate metabolism, and tissue-tissue interactions. Studies using in vitro and in vivo models, clinical studies and methods for the measurement of steroid metabolites are welcome.

Prof. Dr. Walter Wahli
Guest Editor

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