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  • Article
  • Open Access

How Emotion Regulation and Illness Identity Shape Mental Health in Adults with Congenital Heart Disease

  • Anna-Lena Ehmann,
  • Daniel T. Marggrander,
  • Janina Semmler,
  • Felix Berger,
  • Paul C. Helm and
  • Constanze Pfitzer
Med. Sci.2026, 14(1), 2;https://doi.org/10.3390/medsci14010002 
(registering DOI)

19 December 2025

Background/Objectives: Adults with congenital heart disease (ACHD) are at increased risk for mental health problems, particularly depression and anxiety. Emerging evidence suggests that psychological rather than purely medical factors may play a deci...

  • Article
  • Open Access

Feasibility of the Manual Diaphragm Release Technique in Neurocritical Patients on Mechanical Ventilation: A Pilot Randomized Controlled Trial

  • Elis Fernanda Araújo Lima de Oliveira,
  • Helga Cecília Muniz de Souza,
  • Heitor Fernandes Silveira Cavalini,
  • Fabianne Maisa de Novaes Assis Dantas,
  • Victor Ribeiro Neves,
  • Fernando de Aguiar Lemos,
  • Marcelo Gama de Abreu and
  • Paulo André Freire Magalhães
Med. Sci.2026, 14(1), 1;https://doi.org/10.3390/medsci14010001 
(registering DOI)

19 December 2025

Introduction: This pilot randomized trial evaluated the feasibility of the Manual Diaphragm Release Technique (MDRT) in neurocritical patients on invasive mechanical ventilation (IMV) and explored its immediate effects on diaphragmatic kinematics to...

  • Article
  • Open Access

18 December 2025

Background: Intestinal angioedema is an important drug-induced adverse effect that is often misdiagnosed due to vague and nonspecific symptoms. This study aimed to identify drugs with potential to cause intestinal angioedema by performing a dispropor...

  • Article
  • Open Access

Transcriptomic, Redox Status and Adipocytokine Profiles in Metabolic Dysfunction-Associated Steatotic Liver Disease: Impact of Coexisting Type 2 Diabetes

  • Sanja Erceg,
  • Ana Ninić,
  • Jelena Kotur-Stevuljević,
  • Omar Ben Mariem,
  • Miloš Mitrović,
  • Jelena Munjas,
  • Miron Sopić,
  • Boško Misita,
  • Milica Mamić and
  • Aleksandra Klisic
  • + 1 author

18 December 2025

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) commonly coexists with type 2 diabetes (T2D), but their independent contributions to redox imbalance, inflammation and immune signaling remain uncertain. Objectives: This st...

  • Systematic Review
  • Open Access
57 Views
13 Pages

IL-6 and Surgical Outcomes in Carotid Endarterectomy: A Systematic Review

  • Antónia Rocha-Melo-Sousa,
  • Márcio Brazuna,
  • Carmen Tavares,
  • Sai Guduru,
  • Mariana Fragão-Marques and
  • João Rocha-Neves

18 December 2025

Background: Interleukin-6 (IL-6) is a key inflammatory cytokine implicated in atherosclerotic plaque progression and carotid vulnerability. Although elevated IL-6 levels have been linked to cerebrovascular risk, its prognostic value in patients under...

  • Article
  • Open Access
106 Views
12 Pages

Serum Calcium Concentration Is Associated with Bone Mineral Density and Synonymous Variants in the RYR1 Gene in a Mexican-Mestizo Population

  • Tania V. López-Pérez,
  • Rogelio F. Jiménez-Ortega,
  • Armando Cruz-Rangel,
  • Diana I. Aparicio-Bautista,
  • Juan C. Fernández-López,
  • Adriana Becerra-Cervera,
  • Juan P. Reyes-Grajeda,
  • Jorge Salmerón,
  • Alberto Hidalgo-Bravo and
  • Berenice Rivera-Paredez
  • + 1 author

17 December 2025

Background/Objectives: Serum calcium concentrations have been associated with bone mineral density (BMD), but results seem to depend on sex. Genetic variants in the Ryanodine Receptor1 (RYR1) gene have been previously associated with low BMD in postm...

  • Article
  • Open Access
111 Views
14 Pages

Respiratory Muscle Strength in Hypertensive Adults: Age- and Sex-Specific Reference Values for a Brazilian Population

  • Simone de Faria Rossetto,
  • Juscelio Pereira da Silva,
  • Afonso Santos de Lima,
  • Anderson Geremias Macedo,
  • Dalton Muller Pessôa Filho,
  • Albená Nunes Silva,
  • Thiago Roberto Lima Romero and
  • Giovane Galdino

17 December 2025

Background/Objectives: Hypertension is a major modifiable risk factor for cardiovascular disease and may negatively affect muscle strength through vascular and metabolic mechanisms. Nevertheless, reference values for respiratory muscle strength (RMS)...

  • Article
  • Open Access
270 Views
20 Pages

Obesogenic Dysregulation of Human Periprostatic Adipose Tissue Promotes the Viability of Prostate Cells and Reduces Their Sensitivity to Docetaxel and Cabazitaxel

  • Mariana Feijó,
  • Lara R. S. Fonseca,
  • Gonçalo Catarro,
  • Cátia V. Vaz,
  • Carlos Rabaça,
  • Bruno J. Pereira,
  • Eugenia Gallardo,
  • Endre Kiss-Toth,
  • Sara Correia and
  • Sílvia Socorro

16 December 2025

Background: Periprostatic adipose tissue (PPAT) has been shown to play a significant role in prostate cancer (PCa) development and progression. This relationship is further exacerbated by obesity, as PPAT-secreted factors increase PCa aggressiveness...

  • Article
  • Open Access
221 Views
18 Pages

Empowering Patients: A Multicomponent Workshop Improves Self-Management and Quality of Life in Chronic Pain

  • María Victoria Ruiz-Romero,
  • María Begoña Gómez-Hernández,
  • Ana Porrúa-Del Saz,
  • María Blanca Martínez-Monrobé,
  • Natalia Gutiérrez-Fernández,
  • Almudena Arroyo-Rodríguez,
  • Rosa Anastasia Garrido-Alfaro,
  • Néstor Canal-Diez,
  • María Dolores Guerra-Martín and
  • Consuelo Pereira-Delgado

15 December 2025

Background: Chronic pain is a prevalent and disabling condition, affecting 20–30% of the global population, which requires multidisciplinary approaches integrating non-pharmacological therapies and promoting patient engagement in self-managemen...

  • Review
  • Open Access
118 Views
18 Pages

Why and How Are Infants with Hutchinson–Gilford Progeria Syndrome Born Without Severe Manifestations?

  • Mariia A. Erokhina,
  • Ekaterina A. Vorotelyak,
  • Andrey V. Vasiliev and
  • Vepa K. Abdyev

15 December 2025

Children with Hutchinson–Gilford progeria syndrome (HGPS) are born without height and weight abnormalities, and postnatal development is delayed from two months of age. The pathophysiological manifestations of HGPS can be categorized into the t...

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Med. Sci. - ISSN 2076-3271