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Medicina publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Prenatal Diagnosis: Current Challenges and Future Directions

edited by Maciej Słodki and Oskar Sylwestrzak

submission deadline 30 Nov 2026 | Viewed by 181 | Submission Open

Keywords: prenatal diagnosis; non-invasive prenatal testing (NIPT); fetal imaging; fetal echocardiography; neurosonography; genomic medicine; intrauterine therapy; congenital anomalies; genetic counseling; maternal–fetal medicine

(This special issue belongs to the Section Obstetrics and Gynecology)

Anesthesiology, Resuscitation, and Pain Management

edited by

Diana Cimpoesu

, Ovidiu-Horea Bedreag and Mihai Octavian Botea

submission deadline 10 Dec 2026 | 9 articles | Viewed by 16179 | Submission Open

Keywords: anesthesiology; resuscitation; pain medicine; general anesthesia; regional anesthesia; emergency medicine; perioperative anesthesia

(This special issue belongs to the Section Intensive Care/ Anesthesiology)

Clinical Diagnosis and Management of Cardiovascular Disease

edited by Federica Marzano,

Paola Gargiulo

and Stefania Paolillo

submission deadline 10 Dec 2026 | 6 articles | Viewed by 5587 | Submission Open

Keywords: cardiovascular disease; clinical diagnosis; risk stratification; biomarkers; cardiovascular imaging; personalized medicine; therapeutic management; preventive cardiology

(This special issue belongs to the Section Cardiology)

Advances in Multiple Sclerosis: From Pathogenesis to Therapeutics

edited by

Dimos D. Mitsikostas

and

Panagiotis Gklinos

submission deadline 10 Dec 2026 | 1 articles | Viewed by 1887 | Submission Open

Keywords: multiple sclerosis; biomarkers; imaging; McDonald 2024 criteria; disease-modifying therapies; smoldering disease; progression independent of relapse activity; remyelination; microglia; clinical research

(This special issue belongs to the Section Neurology)

The Role of Gut Microbiota in Health and Diseases—Latest Findings

edited by María José Lorenzo Pisarello

submission deadline 10 Dec 2026 | Viewed by 171 | Submission Open

Keywords: gut microbiota; dysbiosis; gut–brain axis; gut–liver axis; microbial metabolites; short-chain fatty acids (SCFAs); metabolic diseases; microbiota-targeted therapies; probiotics and postbiotics; precision nutrition

(This special issue belongs to the Section Gastroenterology & Hepatology)

Pathophysiological Mechanisms and Therapeutic Strategies in Kidney Diseases

edited by

Kumar Digvijay

and Henrik Birn

submission deadline 10 Dec 2026 | Viewed by 134 | Submission Open

Keywords: kidney diseases; pathophysiology; therapeutic strategies; extracellular vesicles; biomarkers; regenerative nephrology; transplant medicine; precision diagnostics; glomerular disorders; acute kidney injury; chronic kidney disease

(This special issue belongs to the Section Urology & Nephrology)

Advances in Diagnosis and Treatment of Orthopedic Disorders

edited by Marcin K. Krzysztof Waśko

submission deadline 11 Dec 2026 | 5 articles | Viewed by 5027 | Submission Open

Keywords: knee disorders; sports traumatology; musculoskeletal imaging; quantitative MRI; knee biomechanics; ligament reconstruction; patellofemoral instability; arthroscopy; musculoskeletal rehabilitation

(This special issue belongs to the Section Orthopedics)

Outcomes After Surgical Treatment of Pelvic Organ Prolapse

edited by Justina Kačerauskienė and Roger Roman Dmochowski

submission deadline 15 Dec 2026 | 3 articles | Viewed by 5862 | Submission Open

Keywords: pelvic organ prolapse; surgery; recurrence; vaginal hysterectomy; sacrocolpopexy; Manchester operation; sacrospinous fixation; native tissue

(This special issue belongs to the Section Obstetrics and Gynecology)

Advances and Challenges in Skeletal Diseases

edited by

Sebastian Głowiński

and

Aleksandra Bryndal

submission deadline 15 Dec 2026 | 5 articles | Viewed by 5596 | Submission Open

Keywords: musculoskeletal diseases; rehabilitation; physiotherapy; manual therapy; exercise therapy; virtual reality rehabilitation; robotic therapy; pain management; telerehabilitation

(This special issue belongs to the Section Orthopedics)

Recent Advances in Otological Diseases

edited by

Andrea Frosolini

submission deadline 15 Dec 2026 | 3 articles | Viewed by 5430 | Submission Open

Keywords: otology; hearing loss; tinnitus; otitis media; vestibular disorders; diagnostic methods; treatment; surgery; epidemiology; medical devices

Updates on Allergies and Immunodeficiencies

edited by

Carmen Panaitescu

and

Maria Roxana Buzan

submission deadline 15 Dec 2026 | 4 articles | Viewed by 5271 | Submission Open

Keywords: allergy; immunodeficiency; allergens; cross-reactivity; molecular allergy diagnostics; immunotherapy; precision medicine; exposome

(This special issue belongs to the Section Hematology and Immunology)

Diagnosis, Management, and Treatment of Hearing Loss

edited by

Francesco Ciodaro

and

Daniele Portelli

submission deadline 15 Dec 2026 | 3 articles | Viewed by 3748 | Submission Open

Keywords: hearing loss; otology; auditory rehabilitation; hearing aids; cochlear implants; regenerative medicine; precision audiology; artificial intelligence; tele-audiology; hearing health

New Development of Rehabilitation Interventions for People with Complex Psychosis

edited by

Emanuele Caroppo

Marianna Mazza

and Giuseppe Marano

submission deadline 15 Dec 2026 | 2 articles | Viewed by 2547 | Submission Open

Keywords: complex psychosis; psychiatric rehabilitation; cognitive remediation; recovery-oriented care; digital health interventions

(This special issue belongs to the Section Psychiatry)

Erectile Dysfunction Therapy: Recent Advances and Approaches

edited by Zisis Kratiras and

Ilias Giannakodimos

submission deadline 15 Dec 2026 | 1 articles | Viewed by 846 | Submission Open

Keywords: erectile dysfunction; PDE5 inhibitors; regenerative treatment; neuromodulation; penile implant; pharmacology

(This special issue belongs to the Section Urology & Nephrology)

Lupus Nephritis: Diagnosis and Treatment

edited by Giovanni M. Rossi

submission deadline 15 Dec 2026 | 1 articles | Viewed by 768 | Submission Open

Keywords: lupus nephritis; systemic lupus erythematosus; complement; kidney biopsy; nephropathology

(This special issue belongs to the Section Urology & Nephrology)

Current Trends in Prosthodontic Rehabilitation: Conventional and Implant-Supported Solutions

edited by

Asja Čelebić

Nikola Petričević

and

Sanja Peršić Kiršić

submission deadline 15 Dec 2026 | 1 articles | Viewed by 494 | Submission Open

Keywords: prosthodontics; rehabilitation; conventional prosthodontics; implant prosthodontics; implant-supported (or retained) restorations; dental implants; digital dentistry; CAD/CAM; biomaterials; fixed or removable prosthodontics; edentulism; treatment planning; clinical outcomes; longevity of prosthetic restorations; esthetic dentistry; oral rehabilitation; patient-reported outcomes; occlusion; biomechanical research; gerodontology; questionnaires and their psychometric properties

(This special issue belongs to the Section Dentistry and Oral Health)

New Technologies and Strategies for Treatment of Cataract Surgery

edited by Jaroslaw Kocięcki and Sławomir Liberski

submission deadline 19 Dec 2026 | 1 articles | Viewed by 912 | Submission Open

Keywords: cataract surgery; phacoemulsification; intraocular lenses; femtosecond laser; artificial intelligence in cataract surgery; surgical innovations

(This special issue belongs to the Section Ophthalmology)

Chronic Kidney Disease: From Early Detection to Modern Management Strategies

edited by

Domenico Giannese

submission deadline 20 Dec 2026 | 3 articles | Viewed by 3430 | Submission Open

Keywords: proteinuria; chronic kidney disease; SGLT2-I; management of CKD; nephroprotection

(This special issue belongs to the Section Urology & Nephrology)

Emerging Trends in Total Joint Arthroplasty

edited by

Pier Francesco Indelli

and Stefano Ghirardelli

submission deadline 20 Dec 2026 | 2 articles | Viewed by 3310 | Submission Open

Keywords: gait analysis; PJI; revision surgery; personalized surgery; implant design; soft tissue balancing

(This special issue belongs to the Section Orthopedics)

Breaking the Pain Cycle in Osteoarthritis: From Drugs to Rehabilitation

edited by Alessandro Conforti

submission deadline 20 Dec 2026 | 1 articles | Viewed by 1173 | Submission Open

Keywords: osteoarthritis; chronic pain; pain management; rehabilitation; physiotherapy; cryoultrasound therapy; pharmacological treatment; NSAIDs; intra-articular injections; GLP-1; metabolic factors; central sensitization; multimodal therapy; personalized medicine; non-pharmacological interventions

(This special issue belongs to the Section Orthopedics)

Osteoarthritis: New Insights and Future Directions

edited by Ciubean Alina Deniza and

Viorela Mihaela Ciortea

submission deadline 20 Dec 2026 | 1 articles | Viewed by 947 | Submission Open

Keywords: osteoarthritis; musculoskeletal rehabilitation; pain management; functional recovery; exercise therapy; non-pharmacological interventions

(This special issue belongs to the Section Orthopedics)

Advances in Clinical Pharmacy: From Clinical Trials to Patient Safety

edited by

Radiana Staynova

Elisaveta Georgieva Apostolova

and

Vesela Kokova

submission deadline 20 Dec 2026 | Viewed by 176 | Submission Open

Keywords: decentralized clinical trials; patient safety; adverse drug reactions; clinical pharmacy; pharmacotherapy; polypharmacy optimization; real world evidence; pharmacovigilance AI

(This special issue belongs to the Section Pharmacology)

Recent Advances in Diagnosis and Therapy of Gynecologic and Breast Cancers

edited by

Daniela-Cristina Stefan

Laurentiu Simion

Vlad Rotaru

and

Elena Chitoran

submission deadline 21 Dec 2026 | 6 articles | Viewed by 32290 | Submission Open

Keywords: gynecologic cancer; breast cancer; biomarkers; novel therapies; personalized medicine; debulking surgery; molecular therapies; genetic predisposition; quality of life; patient-reported outcomes

(This special issue belongs to the Section Obstetrics and Gynecology)

Diagnostic Imaging: Recent Advancements and Future Developments

edited by

Alberto Negro

, Fabio Tortora and

Mario Tortora

submission deadline 22 Dec 2026 | 5 articles | Viewed by 6504 | Submission Open

Keywords: diagnostic imaging; medical imaging technologies; artificial intelligence in radiology; imaging biomarkers; precision medicine; hybrid imaging (e.g., PET/MRI, PET/CT); image-guided interventions; radiomics and machine learning; functional and molecular imaging; clinical applications of imaging

(This special issue belongs to the Section Surgery)

Clinical Practice and Future Challenges in Abdominal Surgery

edited by Bojan Krebs, Arpad Ivanecz and

Irena Plahuta

submission deadline 25 Dec 2026 | 3 articles | Viewed by 4072 | Submission Open

Keywords: abdominal surgery; gastrointestinal oncology; hernia; minimally invasive surgery; surgical techniques; surgical innovation; endoscopy; nutrition; inflammation; outcomes

(This special issue belongs to the Section Surgery)

Aortic Stenosis: Pathophysiological Mechanism, Multimodality Imaging, and Contemporary Treatment

edited by Elio Haroun and

Tom Kai Ming Wang

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1460 | Submission Open

Keywords: aortic stenosis; pathophysiology; multimodality imaging; echocardiography; cardiac computed tomography (CT); cardiac magnetic resonance (CMR); transcatheter aortic valve replacement (TAVR); surgical aortic valve replacement (SAVR); risk stratification; prognosis

(This special issue belongs to the Section Cardiology)

Advances in Total Hip Arthroplasty: From Diagnosis to Treatment

edited by

Thomas W. Wainwright

and

Rob Middleton

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1033 | Submission Open

Keywords: total hip arthroplasty; preoperative planning and imaging; robotics and navigation; patient-specific instrumentation; smart prostheses; augmented reality in surgery; digital rehabilitation; multidisciplinary care

(This special issue belongs to the Section Orthopedics)

Coronary Artery Disease from Acute Manifestation to Long Term Consequences

edited by

Elena Emilia Babeş

submission deadline 30 Dec 2026 | 7 articles | Viewed by 11889 | Submission Open

Keywords: coronary artery disease; acute coronary syndrome; coronary revascularization; coronary angiography; CT angiography; antiplatelet therapy; inflammation

(This special issue belongs to the Section Cardiology)

Emerging Biomarkers in Parkinsonian Syndromes and Dementias: From Diagnosis to Therapeutic Targets

edited by

Anastasia Bougea

submission deadline 30 Dec 2026 | Viewed by 220 | Submission Open

Keywords: Parkinsonian syndromes; dementias; biomarkers

(This special issue belongs to the Section Neurology)

Update on Obstetric Anaesthesia and Perinatology

edited by Tatjana Stopar-Pintarič and

Miha Lučovnik

submission deadline 30 Dec 2026 | Viewed by 166 | Submission Open

Keywords: obstetric anaesthesia; perinatology; labour analgesia; epidural analgesia; remifentanil patient-controlled analgesia; maternal obesity; high-risk pregnancy; maternal comorbidities; hypertensive disorders of pregnancy; obstetric haemorrhage

(This special issue belongs to the Section Intensive Care/ Anesthesiology)

Drug-Induced Anaphylaxis: Advances in Diagnosis, Biomarkers and Rapid Drug Desensitization

edited by Ticha Rerkpattanapipat

submission deadline 30 Dec 2026 | Viewed by 161 | Submission Open

Keywords: drug-induced anaphylaxis; drug hypersensitivity reactions; biomarkers; in vitro test; drug provocation test; drug desensitization; biologics and chemotherapy hypersensitivity

(This special issue belongs to the Section Hematology and Immunology)

Spinal Surgery: Advances and Concerns

edited by Filippo Migliorini and Gaetano Pappalardo

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2953 | Submission Open

Keywords: spine; surgery; minimally invasive; deformity; motion preservation; oncology; infections; trauma; complications; instrumentation; outcomes

(This special issue belongs to the Section Neurology)

Implementing Technological Advances in Psychiatry: Challenges and Opportunities

edited by

Mirko Manchia

and Alessio Squassina

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1136 | Submission Open

Keywords: precision psychiatry; machine learning; risk stratification; pharmagenomics; AUC; black box; genomics; epigenetics

(This special issue belongs to the Section Psychiatry)

Osteoarthritis: Innovations in Joint Preservation and Replacement

edited by

Hassan Zmerly

Massimiliano Mosca

and

Silvio Caravelli

submission deadline 31 Dec 2026 | 1 articles | Viewed by 580 | Submission Open

Keywords: osteoarthritis; cartilage; arthroscopy; joint replacement; knee arthroplasty; hip arthroplasty; ankle arthroplasty; robotic

(This special issue belongs to the Section Orthopedics)

Latest Advances of Colorectal Surgery

edited by

Dragoş Eugen Georgescu

submission deadline 31 Dec 2026 | Viewed by 396 | Submission Open

Keywords: minimally invasive surgery; colorectal cancer; surgical outcomes; enhanced recovery after surgery; perioperative management

(This special issue belongs to the Section Gastroenterology & Hepatology)

Structural Heart Interventions and Interventional Imaging: Current Advances and Future Directions

edited by

Kasparas Briedis

and Jorge Sanz-Sánchez

submission deadline 31 Dec 2026 | Viewed by 363 | Submission Open

Keywords: structural heart disease; transcatheter interventions; interventional cardiology; multimodality imaging; TAVI; transcatheter mitral and tricuspid interventions

(This special issue belongs to the Section Cardiology)

Recent Advances in Pulmonary Hypertension: Diagnosis and Treatment

edited by Yuri Matusov and Suhail Dohad

submission deadline 31 Dec 2026 | Viewed by 215 | Submission Open

Keywords: pulmonary hypertension; PH-ILD; interstitial lung disease; right ventricular failure; PH-COPD; HFpEF-PH

(This special issue belongs to the Section Pulmonology)

Fundamental Principles and Contemporary Advances in Orthopaedics and Trauma Surgery

edited by Christoph Linhart and Daniel Pfeufer

submission deadline 31 Dec 2026 | Viewed by 203 | Submission Open

Keywords: orthopaedics surgery; traumatology; functional treatment; bone quality assessment; osteoporosis; pelvic insufficiency fractures; orthogeriatric; periprosthetic fracture; osteosynthesis; nonunion; fracture healing; pseudarthrosis; delayed fracture

(This special issue belongs to the Section Orthopedics)

Advancing Precision in Breast Cancer Regional Nodal Irradiation

edited by

Seung-Gu Yeo

submission deadline 31 Dec 2026 | Viewed by 161 | Submission Open

Keywords: breast cancer; radiation therapy; regional nodal irradiation; lymphedema; incidental irradiation; axillary lateral vessel thoracic junction; target volume

(This special issue belongs to the Section Oncology)

Advances in Neurodegenerative Diseases: From Molecular Mechanisms to Therapeutic Strategies

edited by

Sujung Yeo

submission deadline 31 Dec 2026 | Viewed by 146 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; neurodegeneration; protein aggregation; neuroinflammation; neuroprotection; biomarkers; therapeutic targets

(This special issue belongs to the Section Neurology)

Advances in the Field of Neurology: Innovations in Research and Treatment

edited by

Alberto Ouro

and

Allison B. Reiss

submission deadline 10 Jan 2027 | 6 articles | Viewed by 10871 | Submission Open

Keywords: neuron; synapse; neuroinflammation; motor neuron diseases; neurodegeneration; myelin; seizures

(This special issue belongs to the Section Neurology)

Coping Strategies Across the Lifespan: Psychological and Neuropsychological Perspectives

edited by

Argyroula Kalaitzaki

Maria Theodoratou

and Panoraia Andriopoulou

submission deadline 10 Jan 2027 | 1 articles | Viewed by 2266 | Submission Open

Keywords: coping; clinical psychology; neuropsychology; resilience; brain plasticity; adaptation; quality of life; cognitive function; emotional regulation; stress adaptation; lifespan

(This special issue belongs to the Section Psychiatry)

Innovations and Challenges in Thoracic Surgery: Present and Future Directions

edited by Servet Bölükbas and Konstantinos Grapatsas

submission deadline 10 Jan 2027 | 1 articles | Viewed by 1473 | Submission Open

Keywords: thoracic surgery; lung cancer; pulmonary metastasectomy; mesothelioma; lung volume reduction surgery; minimally invasive surgery (VATS/ RATS); enhanced recovery after surgery (ERAS) protocols; multidisciplinary care; surgical oncology; postoperative outcomes

(This special issue belongs to the Section Surgery)

Diagnostic Approaches and Therapies of Periodontitis

edited by Aureliana Caraiane and Doriana Agop-Forna

submission deadline 10 Jan 2027 | 1 articles | Viewed by 569 | Submission Open

Keywords: periodontitis; oral health-related quality of life; peri-prosthetic tissues; periodontal–prosthetic interface; treatment planning; regenerative periodontal therapy

(This special issue belongs to the Section Dentistry and Oral Health)

Real-World Implementation of CBT for OCD: Access, Adaptation, and Digital Innovations Across Care Settings

edited by

Keiichiro Mukai

and Bethany May Wootton

submission deadline 10 Jan 2027 | Viewed by 562 | Submission Open

Keywords: obsessive–compulsive disorder (OCD); cognitive behavioral therapy (CBT); implementation; real-world effectiveness; digital CBT; Internet-based CBT (iCBT); app-based interventions; blended care; stepped care; low-intensity CBT; high-intensity CBT; access to care; health systems

(This special issue belongs to the Section Psychiatry)

Ulcerative Colitis: Pathogenesis, Clinical Management, and Emerging Therapies

edited by Olga Giouleme and

Alexandra Menni

submission deadline 10 Jan 2027 | Viewed by 390 | Submission Open

Keywords: ulcerative colitis; biological therapies; microbiome; innovative techniques; drug monitoring; prognostic tools; diagnosis and treatment algorithm

(This special issue belongs to the Section Gastroenterology & Hepatology)

Surgical Advances in Genitourinary Reconstruction

edited by

Miroslav L. Djordjevic

, Marta Bizic and Borko Stojanovic

submission deadline 10 Jan 2027 | Viewed by 132 | Submission Open

Keywords: genitalia; congenital anomalies; surgery; reconstruction; transgender

(This special issue belongs to the Section Urology & Nephrology)

Opportunities and Challenges in Brain and Spine Tumor Treatment in the Era of Artificial Intelligence and Precision Medicine

edited by

Mirza Pojskić

and

Benjamin Saß

submission deadline 10 Jan 2027 | Viewed by 121 | Submission Open

Keywords: neuro-oncology; brain tumors; spinal tumors; artificial intelligence; precision medicine; neuro-navigation; augmented reality; robotics in neurosurgery; navigated 3D ultrasound; radiomics; computational neurosurgery; fluorescence-guided surgery

(This special issue belongs to the Section Neurology)

Advances and Perspectives in Esophageal Cancer Treatment

edited by Koji Otsuka and

Florin Achim

submission deadline 15 Jan 2027 | 2 articles | Viewed by 10474 | Submission Open

Keywords: minimally invasive esophagectomy; robotic esophagectomy; locally advanced esophageal cancer; immunotherapy for esophageal cancer; cervical esophageal cancer; multidisciplinary approach to esophageal cancer

(This special issue belongs to the Section Surgery)

New Insights into Heart Failure Management and Treatment

edited by

Alejandro N. Barbagelata

and Edgardo J. Kaplinsky

submission deadline 15 Jan 2027 | 3 articles | Viewed by 3731 | Submission Open

Keywords: heart failure; cardiovascular disease; treatment advances; management strategies; personalized medicine; clinical guidelines; diagnostic innovations; multidisciplinary care; emerging therapies; patient outcomes

(This special issue belongs to the Section Cardiology)

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