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Medicina
Special Issues
Coronary Artery Disease from Acute Manifestation to Long Term Consequences
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Coronary Artery Disease from Acute Manifestation to Long Term Consequences

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 1 October 2025 | Viewed by 890

Special Issue Editor

Dr. Elena Emilia Babeş

E-Mail Website
Guest Editor
Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania
Interests: coronary artery disease; acute coronary syndrome; heart failure; pulmonary embolism; endocarditis

Special Issue Information

Dear Colleagues,

Despite considerable advances over the last decades, coronary artery disease (CAD) remains a major cause of death worldwide. Acute coronary syndrome (ACS) is often the first clinical manifestation of CAD and continues to represent a significant challenge regarding its optimal diagnosis and management both in the acute phase and also in the long term after the acute event.

In this Special Issue of Medicina, we aim to reveal the latest developments in the diagnosis and management of CAD, from its acute forms of manifestation to long-term consequences, in order to provide the best care to every individual patient.

Research areas may include (but are not limited to) the added role of new biomarkers and non-invasive methods such as CT coronary angiography or MRI in the diagnosis of ACS, risk stratification, optimal revascularization strategies, intracoronary imaging-guided revascularization and physiology assessment of myocardial reperfusion after interventional revascularization, prevention and treatment of microvascular obstruction, the optimal timing of coronary revascularization for non-infarct-related arteries and approaches to multivessel disease, optimal antiplatelet strategy, inflammation as a treatment target, new treatment options, using mRNA- and siRNA-based therapies targeting lipid metabolism and inflammation, stem cells, nanotechnology, secondary prevention, and long-term management to reduce complications. We look forward to receiving your valuable contribution to this project.

Dr. Elena Emilia Babeş
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary artery disease
  • acute coronary syndrome
  • coronary revascularization
  • coronary angiography
  • CT angiography
  • antiplatelet therapy
  • inflammation

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Published Papers (1 paper)

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Research

16 pages, 735 KiB  
Article
Factors Associated with Mortality Risk in Patients with Cardiogenic Shock Post-ST-Elevation Myocardial Infarction: Insights from a Regional Centre in Northwest Romania
by Călin Florin Pop, Camelia Alexandra Coadă, Mihai Lupu, Ioan Florin Ferenț, Roxana Ioana Hodas, Andreea Pintilie and Mădălina-Ştefana Ursu
Medicina 2025, 61(4), 725; https://doi.org/10.3390/medicina61040725 - 14 Apr 2025
Cited by 1 | Viewed by 617
Abstract
Background and Objectives: ST elevation myocardial infarction (STEMI), particularly when complicated by cardiogenic shock (CS), is a critical condition associated with high mortality rates. Identifying predictors of in-hospital mortality can enhance patient management and outcomes. Materials and Methods: This observational, retrospective [...] Read more.
Background and Objectives: ST elevation myocardial infarction (STEMI), particularly when complicated by cardiogenic shock (CS), is a critical condition associated with high mortality rates. Identifying predictors of in-hospital mortality can enhance patient management and outcomes. Materials and Methods: This observational, retrospective case–control study included STEMI patients, both complicated and uncomplicated by CS. Additionally, demographics, clinical characteristics, laboratory data and in-hospital mortality rates were analysed for STEMI patients with CS and those without CS. Results: This study included a total of 101 patients with STEMI, of whom 51 (50.5%) had STEMI without CS and 50 (49.5%) had STEMI with CS. No significant differences were observed in demographic characteristics or STEMI risk factors between the two groups. Emergency coronarography was performed in 90.1% of the patients, with successful thrombolysis achieved in 24.5%. Patients with CS exhibited a significantly higher mortality (52%) than those without CS (11.76%). Univariate analysis identified white blood cell counts, CK-MB, CK levels, elevated creatinine and uric acid levels and a reduced left ventricular ejection fraction (LVEF) as predictors of mortality. Logistic regression analysis revealed that LVEF and CK-MB were independent predictors of in-hospital mortality in patients with STEMI and CS. Each 1% increase in LVEF was associated with a reduced mortality risk (HR = 0.89; 95% CI 0.81–0.98; p = 0.018), while elevated CK-MB levels were linked to an increased mortality risk (HR = 1; 95% CI 1–1.01; p = 0.014). Conclusions: Reduced systolic function and elevated CK-MB levels are key predictors of in-hospital mortality and outcomes in STEMI patients with CS. These findings underscore the importance of early identification and support the development of targeted management strategies aimed at improving outcomes in this high-risk population. Full article
(This article belongs to the Special Issue Coronary Artery Disease from Acute Manifestation to Long Term Consequences)
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