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Medicina
Special Issues
New Development of Rehabilitation Interventions for People with Complex Psychosis
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New Development of Rehabilitation Interventions for People with Complex Psychosis

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Psychiatry".

Deadline for manuscript submissions: 15 December 2026 | Viewed by 1294

Special Issue Editors

Dr. Emanuele Caroppo

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Guest Editor
Department of Mental Health, Local Health Authority Roma 2, 00159 Rome, Italy
Interests: public mental health; migrant’s mental health; severe psychiatric disorders; psychoanalysis and psychotherapy; gender-related mental health disorders; mental health epidemiology; post-traumatic stress disorder; social psychiatry; gender violence
Dr. Marianna Mazza

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Guest Editor
1. Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy
2. Unit of Psychiatry, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Interests: mood disorders; anxiety; psychosis; personality disorders; cardiovascular disorders; clinical psychopharmacology; psychiatric emergencies; peripartum; interpersonal violence
Special Issues, Collections and Topics in MDPI journals
Dr. Giuseppe Marano

E-Mail Website
Guest Editor
1. Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy
2. Unit of Psychiatry, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Interests: mental health; neurobiology neuroscience; women's health; clinical trials; bipolar disorder; mood disorders translation science; research methods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Complex psychosis poses a significant challenge for clinicians, researchers, and health systems. In addition to persistent psychotic symptoms, individuals often experience cognitive impairment, social withdrawal, and reduced autonomy. These factors significantly hinder recovery and participation in daily life. While traditional treatments are essential, they are not sufficient on their own. Therefore, there is an increasing need to design and test new rehabilitation strategies that integrate scientific evidence with practical, patient-centered care.

This Special Issue seeks to bring together high-quality contributions exploring the latest developments in rehabilitation for complex psychosis. We welcome original research, reviews, and clinical perspectives addressing psychosocial interventions, cognitive remediation, and peer-led or family-based programs. We are particularly interested in innovations that use digital technologies, such as telerehabilitation, mobile health applications, and virtual reality, to promote engagement and recovery. We also value contributions that highlight interdisciplinary collaboration and the personalization of care.

By combining empirical evidence with clinical innovation, this Special Issue aims to promote recovery-oriented models of care, stimulate debate, and inspire new practices that can transform rehabilitation for people living with complex psychosis.

Dr. Emanuele Caroppo
Dr. Marianna Mazza
Dr. Giuseppe Marano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • complex psychosis
  • psychiatric rehabilitation
  • cognitive remediation
  • recovery-oriented care
  • digital health interventions

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Published Papers (2 papers)

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Review

19 pages, 905 KB  
Review
Rehabilitation in Adults with Complex Psychosis: A Clinician-Oriented Narrative Review of Multidimensional Approaches to Functional Recovery
by Mario Pinzi, Andrea Fagiolini, Giacomo Gualtieri, Maria Beatrice Rescalli, Caterina Pierini, Alessia Santangelo, Benjamin Patrizio and Alessandro Cuomo
Medicina 2026, 62(5), 841; https://doi.org/10.3390/medicina62050841 - 28 Apr 2026
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Abstract
Complex psychosis is a clinically relevant rehabilitation construct rather than a formal diagnostic category and refers to psychotic illness associated with treatment-resistant symptoms, functional impairment, and additional cognitive, psychiatric, neurodevelopmental, or physical health complexity. In this clinician-oriented narrative review, we synthesised current evidence [...] Read more.
Complex psychosis is a clinically relevant rehabilitation construct rather than a formal diagnostic category and refers to psychotic illness associated with treatment-resistant symptoms, functional impairment, and additional cognitive, psychiatric, neurodevelopmental, or physical health complexity. In this clinician-oriented narrative review, we synthesised current evidence on rehabilitation interventions for adults with complex psychosis, integrating direct evidence from specialist rehabilitation settings with indirect evidence from schizophrenia-spectrum studies when clinically informative. We searched major clinical databases, prioritised guidelines, systematic reviews, meta-analyses, and controlled studies, and organised the synthesis by functional domain and pathway relevance. Evidence was strongest for cognitive remediation, particularly when combined with broader psychiatric rehabilitation or vocational support, for family interventions in relapse prevention, and for individual placement and support in competitive employment. Social–cognitive and metacognitive interventions appear clinically valuable, although transfer to real-world functioning is more variable. Community-based rehabilitation, supported accommodation, illness self-management, and ecological adaptation strategies remain central to functional recovery when embedded within multidisciplinary pathways. Digital and virtual interventions are promising adjuncts, but their efficacy remains heterogeneous and implementation challenges include engagement, privacy, and service integration. Overall, rehabilitation in complex psychosis is most convincing when it is personalised, measurement-based, and delivered through integrated service models linking assessment, intervention selection, supported living, and recovery-oriented care. Full article
(This article belongs to the Special Issue New Development of Rehabilitation Interventions for People with Complex Psychosis)
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21 pages, 1543 KB  
Review
Digital and Immersive Technologies for Rehabilitation in Complex Psychosis: State of the Art and Future Directions
by Giuseppe Marano, Mariateresa Acanfora, Giuseppe Mandracchia, Gianandrea Traversi, Osvaldo Mazza, Antonio Pallotti, Giorgio Veneziani, Carlo Lai, Emanuele Caroppo and Marianna Mazza
Medicina 2026, 62(4), 765; https://doi.org/10.3390/medicina62040765 - 15 Apr 2026
Viewed by 571
Abstract
Complex psychosis (CP) remains one of the most challenging conditions in mental health, characterized by persistent symptoms, cognitive impairment, functional disability, and reduced autonomy. Traditional rehabilitation approaches, although essential, are often insufficient to address the multidimensional needs of these individuals. Over the past [...] Read more.
Complex psychosis (CP) remains one of the most challenging conditions in mental health, characterized by persistent symptoms, cognitive impairment, functional disability, and reduced autonomy. Traditional rehabilitation approaches, although essential, are often insufficient to address the multidimensional needs of these individuals. Over the past decade, rapid advances in digital health have opened new opportunities to enhance psychosocial rehabilitation, improve engagement, and personalize treatment pathways. This narrative review synthesizes current evidence on the use of digital and immersive technologies in the rehabilitation of people with CP, including virtual reality (VR), augmented reality (AR), telerehabilitation platforms, mobile health (m-Health) applications, digital phenotyping, and AI-assisted cognitive remediation. We examine clinical trials, feasibility studies, and real-world implementations published between 2015 and 2025, highlighting the efficacy of VR-based social cognition training, remote cognitive remediation, ecological momentary interventions, and hybrid digital–in-person rehabilitation models. Mechanisms of action, transfer to real-world functioning, and predictors of engagement are described. Barriers such as digital literacy, access disparities, privacy concerns, and clinical integration are critically discussed. We also outline future directions, including adaptive algorithms, biosensor integration, and the development of multimodal digital ecosystems tailored to individual recovery trajectories. By integrating technological innovation with recovery-oriented care, digital rehabilitation tools have the potential to transform the treatment landscape for people with CP. This review offers a roadmap for clinicians, researchers, and policymakers seeking to incorporate evidence-based digital solutions into modern psychiatric rehabilitation. Full article
(This article belongs to the Special Issue New Development of Rehabilitation Interventions for People with Complex Psychosis)
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