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Medicina
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Emerging Trends in Total Joint Arthroplasty
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Emerging Trends in Total Joint Arthroplasty

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 262

Special Issue Editors

Prof. Dr. Pier Francesco Indelli

E-Mail Website
Guest Editor
1. Institute of Biomechanics, Paracelsus Medical University (PMU), 5020 Salzburg, Austria
2. Department of Orthopaedic Surgery, Südtiroler Sanitätsbetrieb, 39042 Brixen, Italy
3. Department of Orthopaedic Surgery, Stanford University School of Medicine, Redwood City, CA 94061, USA
Interests: gait analysis; total knee arthroplasty; periprosthetic joint infections; PJI; revision surgery; personalized surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Stefano Ghirardelli

E-Mail Website
Guest Editor Assistant
1. Adult Reconstruction and Joint Replacement Hospital for Special Surgery, New York, NY, USA
2. Institute of Biomechanics, Paracelsus Medical University (PMU), 5020 Salzburg, Austria
Interests: gait analysis; knee biomechanic; PJI; revision surgery; personalized surgery

Special Issue Information

Dear Colleagues, 

Total joint arthroplasty (TJA) has undergone transformative advancements in recent years, driven by innovations in surgical technique, implant design, perioperative optimization, and data-driven decision-making. As patient expectations continue to rise and the demand for arthroplasty increases globally, the field is experiencing a paradigm shift toward more personalized, efficient, and outcome-focused care.

This Special Issue titled “Emerging Trends in Total Joint Arthroplasty” highlights key developments shaping the future of hip and knee replacement. Topics include robot-assisted surgery, sensor-enabled implants, enhanced recovery pathways, strategies for infection prevention, soft tissue balancing techniques, and alignment philosophies that challenge traditional mechanical norms. Special attention is also given to the role of big data, registries, and artificial intelligence in guiding clinical decision-making and improving long-term outcomes.

Our goals are to provide a platform for exchanging new ideas and to foster multidisciplinary collaboration among surgeons, researchers, and healthcare professionals. By bringing together cutting-edge research and clinical insights, this Special Issue aims to inform best practices and inspire future innovation in the ever-evolving landscape of total joint arthroplasty.

Prof. Dr. Pier Francesco Indelli
Guest Editor

Dr. Stefano Ghirardelli
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gait analysis
  • PJI
  • revision surgery
  • personalized surgery
  • implant design
  • soft tissue balancing

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Published Papers (1 paper)

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Research

16 pages, 1641 KB  
Article
Accuracy and Early Outcomes of Patient-Specific TKA Using Inertial-Based Cutting Guides: A Pilot Study
by Gianluca Piovan, Andrea Amarossi, Luca Bertolino, Elena Bardi, Alberto Favaro, Lorenzo Povegliano, Daniele Screpis, Francesco Iacono and Tommaso Bonanzinga
Medicina 2025, 61(9), 1554; https://doi.org/10.3390/medicina61091554 - 29 Aug 2025
Viewed by 184
Abstract
Background and objectives: Patient-specific components (PSC) represent an innovative option for total knee arthroplasty (TKA) in advanced osteoarthritis. Their effectiveness, however, closely relies on accurate positioning. Our study investigates the accuracy achieved by means of an inertial-based extramedullary cutting guide and the [...] Read more.
Background and objectives: Patient-specific components (PSC) represent an innovative option for total knee arthroplasty (TKA) in advanced osteoarthritis. Their effectiveness, however, closely relies on accurate positioning. Our study investigates the accuracy achieved by means of an inertial-based extramedullary cutting guide and the postoperative clinical and radiographic outcomes. Methods and materials: This was a prospective, single-arm, pilot study involving patients undergoing primary TKA with YourKneeTM PSC. Femoral and tibial bone resections were performed using the Perseus inertial-based extramedullary cutting guide. Postoperative mechanical alignment and component positioning were assessed by computed tomography. Clinical outcomes were evaluated preoperatively and at 1, 3, 6, and 12 months postoperatively by main knee function and clinical outcome measures. Results: The study population included a small cohort (n= 12, four females/eight males, mean age 69 ± 5.65 years, mean BMI 25.7 ± 3.8 kg/m2, KL grade > 3) with no control group. The mean absolute error between the planned and obtained Hip–Knee–Ankle angle was 1.36° ± 1.06 and within ±3° of all cases. Mean coronal alignment error was 1.87° ± 0.87 and 1.67° ± 0.75 for the femoral and tibial components, respectively. The mean sagittal alignment error was 1.89° ± 1.24 and 2.45° ± 0.87 for the femoral and the tibial components, respectively. Patients showed significant improvement in clinical and functional scores within the first 6 months: OKS increased from 20.64 ± 2.77 at the preoperative screening to 42.27 ± 4.34 (p < 0.0001), total KSS rose from 90.64 ± 17.25 to 169.36 ± 23.57 (p < 0.0001), and FJS reached 85.09 ± 17.14 at 6 months (p = 0.0031), indicating excellent functional recovery and forgotten joint effect. Knee ROM improved from 90.91° ± 11.14 to 110.36° ± 8.44 (p < 0.0001). After 6 months, outcome scores plateaued, suggesting an early stabilization of clinical benefits. No signs of radiolucency were detected on X-rays at 3- and 12-month follow-ups. Conclusions: The Perseus inertial-based extramedullary cutting guide used in combination with the YourKneeTM PSCs resulted in accurate intraoperative prosthesis positioning and significant improvements in clinical and functional outcomes at 6 months after surgery. Despite the small sample size and absence of a control group, the results suggest that such combination represents a viable option to conventional surgical instrumentation and current off-the-shelf prosthetic designs. Full article
(This article belongs to the Special Issue Emerging Trends in Total Joint Arthroplasty)
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