Special Issue "Research of Organic Molecules and Materials for Biological Application"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: 30 January 2021.

Special Issue Editors

Prof. Jacek Ścianowski
E-Mail Website
Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 7 Gagarin Street, 87-100 Torun, Poland
Interests: organic synthesis; terpenes; chalcogenides; antioxidants; anticancer agents
Prof. Marek Krzeminski
E-Mail Website
Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 7 Gagarin Street, 87-100 Torun, Poland
Interests: asymmetric synthesis; organoboranes; terpenes; catalytic reactions; enantioselective reductions

Special Issue Information

Dear Colleagues,

Stress, modern lifestyle, diet, and prolonged survival of people are just a few reasons contributing to modern civilization diseases. Atherosclerosis, diabetes, obesity, oxidative stress, and cancer are contemporary challenges for medicine and, thus, modern organic chemistry. The search for new chemotherapeutics and biologically active materials based on organic components is one of the current research trends. New therapeutics based on small organic molecules, compounds, and materials of natural origin, and reagents containing heteroatoms such as sulfur, selenium, phosphorus, boron, and others are just a few of the challenges facing modern organic synthesis. The search for biologically active reagents also includes new synthetic methodologies such as organocatalysis, stereocontrolled reactions, as well as new solutions in the field of so-called “green chemistry” and “flow chemistry”, e.g., solvent-free reactions, high pressure, ultrasound, and microwaves.

The announced Special Issue is open for research related to the current studies performed in chemical laboratories involving synthesis of organic molecules and materials possessing any kind of biological applications. The works resulting from this research, aimed either at the solution of basic and mechanistic problems or of practical importance, are welcome.

Prof. Jacek Ścianowski
Prof. Marek Krzeminski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic compounds and materials
  • biological activity
  • antioxidants
  • anticancer activity

Published Papers (1 paper)

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Research

Open AccessArticle
Seleninic Acid Potassium Salts as Water-Soluble Biocatalysts with Enhanced Bioavailability
Materials 2020, 13(3), 661; https://doi.org/10.3390/ma13030661 - 02 Feb 2020
Abstract
Organoselenium compounds are well-known glutathione peroxidase (GPx) mimetics that possess antioxidants/prooxidant properties and are able to modulate the concentration of reactive oxygen species (ROS), preventing oxidative stress in normal cells or inducing ROS formation in cancer cells leading to apoptosis. The purpose of [...] Read more.
Organoselenium compounds are well-known glutathione peroxidase (GPx) mimetics that possess antioxidants/prooxidant properties and are able to modulate the concentration of reactive oxygen species (ROS), preventing oxidative stress in normal cells or inducing ROS formation in cancer cells leading to apoptosis. The purpose of this study was the synthesis of potent GPx mimics with antioxidant and anticancer activity along with improved bioavailability, as a result of good solubility in protic solvents. As a result of our research, glutathione peroxidase (GPx) mimetics in the form of water-soluble benzeneseleninic acid salts were obtained. The procedure was based on the synthesis of 2-(N-alkylcarboxyamido)benzeneselenenic acids, through the oxidation of benzisoselenazol-3(2H)-ones or analogous arenediselenides with an amido group, which were further converted to corresponding potassium salts by the treatment with potassium tert-butanolate. All derivatives were tested as potential antioxidants and anticancer agents. The areneseleninic acid salts were significantly better peroxide scavengers than analogous acids and the well-known organoselenium antioxidant ebselen. The highest activity was observed for the 2-(N-ethylcarboxyamido)benzeneselenenic acid potassium salt. The strongest cytotoxic effect against breast cancer (MCF-7) and human promyelocytic leukemia (HL-60) cell lines was found for 2-(N-cyclohexylcarboxyamido)benzeneselenenic acid potassium salt and the 2-(N-ethylcarboxyamido)benzeneselenenic acid, respectively. The structure–activity correlations, including the differences in reactivity of benzeneseleninic acids and corresponding salts were evaluated. Full article
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