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Article

New Polyphenol-Containing LDL Nano-Preparations in Oxidative Stress and DNA Damage: A Potential Route for Cell-Targeted PP Delivery

1
Centre for Radiation Research and Technology, Institute of Nuclear Chemistry and Technology, 16 Dorodna St., 03195 Warsaw, Poland
2
Department of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Sciences, Bialystok University of Technology, Wiejska 45E Street, 15351 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Materials 2020, 13(22), 5106; https://doi.org/10.3390/ma13225106
Received: 14 October 2020 / Revised: 4 November 2020 / Accepted: 10 November 2020 / Published: 12 November 2020
Low-density lipoprotein (LDL) preparations of the chosen polyphenols (PPs) were prepared for the first time in the literature. The solubility of the PPs in the lipidic core of the LDL increased with the increase of their lipophilicity. The anti-/pro-oxidative properties and toxicity of LDL-entrapped PPs toward A 2780 human ovarian cancer cells were examined. The obtained preparations were found to be stable in PBS, and characterized by low toxicity. A binding affinity study revealed that the uptake of PP-loaded LDL particles is non-receptor-specific under experimental conditions. The antioxidative potential of the obtained PPs-doped LDL preparations was shown to be higher than for the PPs themselves, probably due to facilitating transport of LDL preparations into the cellular milieu, where they can interact with the cellular systems and change the redox status of the cell. The PPs-loaded LDL displayed the highest protective effect against Fenton-type reaction induced oxidative DNA damage. View Full-Text
Keywords: polyphenols; low-density lipoprotein; nanoparticles; drug delivery; oxidative stress polyphenols; low-density lipoprotein; nanoparticles; drug delivery; oxidative stress
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MDPI and ACS Style

Lewandowska, H.; Kalinowska, M. New Polyphenol-Containing LDL Nano-Preparations in Oxidative Stress and DNA Damage: A Potential Route for Cell-Targeted PP Delivery. Materials 2020, 13, 5106. https://doi.org/10.3390/ma13225106

AMA Style

Lewandowska H, Kalinowska M. New Polyphenol-Containing LDL Nano-Preparations in Oxidative Stress and DNA Damage: A Potential Route for Cell-Targeted PP Delivery. Materials. 2020; 13(22):5106. https://doi.org/10.3390/ma13225106

Chicago/Turabian Style

Lewandowska, Hanna, and Monika Kalinowska. 2020. "New Polyphenol-Containing LDL Nano-Preparations in Oxidative Stress and DNA Damage: A Potential Route for Cell-Targeted PP Delivery" Materials 13, no. 22: 5106. https://doi.org/10.3390/ma13225106

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