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Open AccessArticle

Silk Fibroin/Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials toward Bone Tissue Regeneration

1
Department of Physical Chemistry and Physicochemistry of Polymers, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland
2
Department of Chemistry of Biomaterials and Cosmetics, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland
3
i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal
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INEB—Instituto de Engenharia Biomédica, Universidade do Porto, 4200-180 Porto, Portugal
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FEUP—Faculdade de Engenharia, Universidade do Porto, 4200-465 Porto, Portugal
6
FLUIDINOVA, S.A., 4470-605 Moreira da Maia, Portugal
*
Author to whom correspondence should be addressed.
Materials 2020, 13(15), 3433; https://doi.org/10.3390/ma13153433
Received: 23 June 2020 / Revised: 23 July 2020 / Accepted: 31 July 2020 / Published: 4 August 2020
In this study, three-dimensional materials based on blends of silk fibroin (SF), collagen (Coll), and chitosan (CTS) cross-linked by glyoxal solution were prepared and the properties of the new materials were studied. The structure of the composites and the interactions between scaffold components were studied using FTIR spectroscopy. The microstructure was observed using a scanning electron microscope. The following properties of the materials were measured: density and porosity, moisture content, and swelling degree. Mechanical properties of the 3D materials under compression were studied. Additionally, the metabolic activity of MG-63 osteoblast-like cells on materials was examined. It was found that the materials were characterized by a high swelling degree (up to 3000% after 1 h of immersion) and good porosity (in the range of 80–90%), which can be suitable for tissue engineering applications. None of the materials showed cytotoxicity toward MG-63 cells. View Full-Text
Keywords: silk fibroin; collagen; chitosan; MG-63; three-component scaffolds; glyoxal solution silk fibroin; collagen; chitosan; MG-63; three-component scaffolds; glyoxal solution
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MDPI and ACS Style

Grabska-Zielińska, S.; Sionkowska, A.; Coelho, C.C.; Monteiro, F.J. Silk Fibroin/Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials toward Bone Tissue Regeneration. Materials 2020, 13, 3433. https://doi.org/10.3390/ma13153433

AMA Style

Grabska-Zielińska S, Sionkowska A, Coelho CC, Monteiro FJ. Silk Fibroin/Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials toward Bone Tissue Regeneration. Materials. 2020; 13(15):3433. https://doi.org/10.3390/ma13153433

Chicago/Turabian Style

Grabska-Zielińska, Sylwia; Sionkowska, Alina; Coelho, Catarina C.; Monteiro, Fernando J. 2020. "Silk Fibroin/Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials toward Bone Tissue Regeneration" Materials 13, no. 15: 3433. https://doi.org/10.3390/ma13153433

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