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Review

Biologically Active Compounds of Plants: Structure-Related Antioxidant, Microbiological and Cytotoxic Activity of Selected Carboxylic Acids

1
Department of Analytical Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciołkowskiego 1K, 15–245 Białystok, Poland
2
Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska 45E, 15–351 Białystok, Poland
3
Institute of Agricultural and Food Biotechnology, Rakowiecka 36, 02–532 Warsaw, Poland
4
Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciołkowskiego 1K, 15–245 Białystok, Poland
*
Authors to whom correspondence should be addressed.
Materials 2020, 13(19), 4454; https://doi.org/10.3390/ma13194454
Received: 6 September 2020 / Revised: 28 September 2020 / Accepted: 1 October 2020 / Published: 8 October 2020
Natural carboxylic acids are plant-derived compounds that are known to possess biological activity. The aim of this review was to compare the effect of structural differences of the selected carboxylic acids (benzoic acid (BA), cinnamic acid (CinA), p-coumaric acid (p-CA), caffeic acid (CFA), rosmarinic acid (RA), and chicoric acid (ChA)) on the antioxidant, antimicrobial, and cytotoxic activity. The studied compounds were arranged in a logic sequence of increasing number of hydroxyl groups and conjugated bonds in order to investigate the correlations between the structure and bioactivity. A review of the literature revealed that RA exhibited the highest antioxidant activity and this property decreased in the following order: RA > CFA ~ ChA > p-CA > CinA > BA. In the case of antimicrobial properties, structure-activity relationships were not easy to observe as they depended on the microbial strain and the experimental conditions. The highest antimicrobial activity was found for CFA and CinA, while the lowest for RA. Taking into account anti-cancer properties of studied NCA, it seems that the presence of hydroxyl groups had an influence on intermolecular interactions and the cytotoxic potential of the molecules, whereas the carboxyl group participated in the chelation of endogenous transition metal ions. View Full-Text
Keywords: phenolic acids; natural carboxylic acids; structure-activity relationship; hydroxyl groups; antibacterial; antioxidant; cytotoxic activity phenolic acids; natural carboxylic acids; structure-activity relationship; hydroxyl groups; antibacterial; antioxidant; cytotoxic activity
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MDPI and ACS Style

Godlewska-Żyłkiewicz, B.; Świsłocka, R.; Kalinowska, M.; Golonko, A.; Świderski, G.; Arciszewska, Ż.; Nalewajko-Sieliwoniuk, E.; Naumowicz, M.; Lewandowski, W. Biologically Active Compounds of Plants: Structure-Related Antioxidant, Microbiological and Cytotoxic Activity of Selected Carboxylic Acids. Materials 2020, 13, 4454. https://doi.org/10.3390/ma13194454

AMA Style

Godlewska-Żyłkiewicz B, Świsłocka R, Kalinowska M, Golonko A, Świderski G, Arciszewska Ż, Nalewajko-Sieliwoniuk E, Naumowicz M, Lewandowski W. Biologically Active Compounds of Plants: Structure-Related Antioxidant, Microbiological and Cytotoxic Activity of Selected Carboxylic Acids. Materials. 2020; 13(19):4454. https://doi.org/10.3390/ma13194454

Chicago/Turabian Style

Godlewska-Żyłkiewicz, Beata, Renata Świsłocka, Monika Kalinowska, Aleksandra Golonko, Grzegorz Świderski, Żaneta Arciszewska, Edyta Nalewajko-Sieliwoniuk, Monika Naumowicz, and Włodzimierz Lewandowski. 2020. "Biologically Active Compounds of Plants: Structure-Related Antioxidant, Microbiological and Cytotoxic Activity of Selected Carboxylic Acids" Materials 13, no. 19: 4454. https://doi.org/10.3390/ma13194454

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