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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Environmental and Microbial Stressors in Neuronal Dysfunction: Mechanistic Insights

edited by

Ovidiu Dumitru Ilie

and Adriana Petrovici

submission deadline 31 Oct 2026 | Viewed by 245 | Submission Open

Keywords: experimental neurotoxicology; neuropsychiatric disorders; neurotrophin signaling; BDNF–Trk pathway; oxidative stress; gut–brain axis; microbiota–brain interactions; toxicant-induced neuronal dysfunction; zebrafish (Danio rerio) model; rodent models; behavioral phenotyping; brain histopathology

(This special issue belongs to the Section Physiology and Pathology)

Molecular Epidemiology and Evolution of Pathogenic Viruses

edited by

Yoshiyuki Suzuki

submission deadline 31 Oct 2026 | Viewed by 207 | Submission Open

Keywords: molecular epidemiology; molecular evolution; pathogenic virus; antigenicity; phylogeny; mutation; recombination; reassortment; natural selection; interspecies transmission

(This special issue belongs to the Section Epidemiology)

Advances in Research on Phytohormones

edited by

Kincső Decsi

submission deadline 1 Nov 2026 | Viewed by 775 | Submission Open

Keywords: stress tolerance; plant hormones; secondary metabolites; biostimulants; nanoparticles; transcriptomics; genome-wide analysis; biochemical pathways; stress defense responses

(This special issue belongs to the Section Plant Science)

Gut Microbiome and Neurodegenerative Disease

edited by Scott A. Jackson and

Leigh A. Frame

submission deadline 15 Nov 2026 | Viewed by 397 | Submission Open

Keywords: gut microbiome; gut–brain axis; neurodegenerative disease; Alzheimer’s disease; Parkinson’s disease; microbiota–host interactions; microbial metabolites; blood–brain barrier; enteric nervous system; vagus nerve signaling; dysbiosis; metagenomics; multi-omics; microbiome biomarkers; translational microbiome research

(This special issue belongs to the Section Physiology and Pathology)

Immunopathology of Oral Mucosal Disease

edited by Dinko Martinovic

submission deadline 15 Nov 2026 | Viewed by 266 | Submission Open

Keywords: immunopathology; immune dysfunction; oral mucosal diseases; oral squamous cell carcinoma; oral potentially malignant disorders; oral lichen planus; recurrent aphthous stomatitis

(This special issue belongs to the Section Physiology and Pathology)

Preload, Afterload and Diastolic Heart Disease

edited by Ryou Tanaka

submission deadline 15 Nov 2026 | Viewed by 172 | Submission Open

Keywords: preload; afterload; diastolic dysfunction; heart failure with preserved ejection fraction (HFpEF); ventricular–arterial coupling; cardiac remodeling; hemodynamic assessment

(This special issue belongs to the Section Physiology and Pathology)

Mucopolysaccharidoses: From Molecular Defects to Therapeutic Strategies

edited by Zuzanna Cyske

submission deadline 20 Nov 2026 | Viewed by 405 | Submission Open

Keywords: mucopolysaccharidosis; mucopolysaccharidosis-plus syndrome; MPSPS; VPS33A; therapy; patomechanism; diagnostic; patients’ care

(This special issue belongs to the Section Medical Research)

Molecular Imaging in Neurodegenerative Diseases

edited by

Chrissa Sioka

and

Alexandros Giannakis

submission deadline 24 Nov 2026 | 1 articles | Viewed by 1828 | Submission Open

Keywords: molecular imaging; neurodegenerative diseases; PET; MRI; radiotracers; amyloid; tau; neuroinflammation; biomarkers; precision medicine

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Molecular Mechanisms and Pharmacological Innovations of Osteoarthritis

edited by Alessandro Conforti and Martina Gentile

submission deadline 27 Nov 2026 | 3 articles | Viewed by 3400 | Submission Open

Keywords: osteoarthritis; pathogenesis; disease-modifying therapies; inflammation; cartilage degeneration

(This special issue belongs to the Section Medical Research)

Musculoskeletal Medicine in Rheumatic Diseases: 2nd Edition

edited by

Florentin Ananu Vreju

and Emilio Filippucci

submission deadline 27 Nov 2026 | 2 articles | Viewed by 1067 | Submission Open

Keywords: rheumatic disease; rheumatoid arthritis; spondylarthritis; microcrystal arthritis; musculoskeletal ultrasonography; biologic treatment; disease-modifying antirheumatic drugs; imagining techniques

(This special issue belongs to the Section Medical Research)

Otolaryngology and Sleep Medicine: From Precision Diagnosis to Advanced Therapeutics

edited by

Antonino Maniaci

submission deadline 28 Nov 2026 | 2 articles | Viewed by 2132 | Submission Open

Keywords: sleep-disordered breathing; otolaryngology; sleep medicine; pulmonology; neurology

(This special issue belongs to the Section Medical Research)

Advances on Physiotherapy and Functional Rehabilitation in Chronic Conditions

edited by

Anna Arnal-Gómez

submission deadline 30 Nov 2026 | 5 articles | Viewed by 7955 | Submission Open

Keywords: physiotherapy; chronic condition; functionality; pain

(This special issue belongs to the Section Medical Research)

Artificial Intelligence and Machine Learning for Biomedical Diagnostics and Prognostics

edited by

César Byron Guevara Maldonado

Victoria López

and

Diego Fernando Riofrío Luzcando

submission deadline 30 Nov 2026 | 6 articles | Viewed by 7162 | Submission Open

Keywords: artificial intelligence; machine learning; diagnostic and prognostic modeling; multimodal data integration; explainable AI

(This special issue belongs to the Section Medical Research)

Microvascular and Macrovascular Response in Healthy and Critically Ill

edited by Andrius Pranskunas and

Marius Brazaitis

submission deadline 30 Nov 2026 | 4 articles | Viewed by 6033 | Submission Open

Keywords: microcirculation; glycocalyx; peripheral perfusion; systemic hemodynamic; body temperature; dynamic maneuvers; remote ischemic conditioning; exercise; adaptation

(This special issue belongs to the Section Physiology and Pathology)

Advances in Veterinary Infectious Diseases: Pathogenesis, Diagnostics, and Control Strategies

edited by

Hye-Mi Lee

submission deadline 30 Nov 2026 | 1 articles | Viewed by 4914 | Submission Open

Keywords: veterinary infectious diseases; zoonoses; animal health; pathogen transmission; vaccine development; immunology; antiviral strategies; emerging pathogens; diagnostic tools; public health

(This special issue belongs to the Section Animal Science)

Neurological and/or Muscle–Skeletal Disorders—Across of the Life Cycle

edited by

Gelu Onose

and Andrada Mirea

submission deadline 30 Nov 2026 | 4 articles | Viewed by 4478 | Submission Open

Keywords: adult neuro-/muscle–skeletal comprehensive prevention, treatment, and rehabilitation; child/adolescent neuro-/muscle-skeletal-comprehensive prevention, treatment, and rehabilitation; elderly neuro-/muscle-skeletal-comprehensive prevention, treatment, and rehabilitation; healthy lifestyle/primary prevention; secondary prevention; functioning; telehealth/medicine

(This special issue belongs to the Section Medical Research)

Advances in Emergency and Critical Care Medicine

edited by

Yu-Jang Su

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4424 | Submission Open

Keywords: emergency medicine; critical care; trauma; infectious diseases; elderly

(This special issue belongs to the Section Medical Research)

Thyroid and Parathyroid Diseases: Advances in Molecular Imaging

edited by

Petra Petranović Ovčariček

and

Luca Giovanella

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3776 | Submission Open

Keywords: thyroid cancer; parathyroid imaging; hyperparathyroidism; benign thyroid diseases; molecular imaging; radioactive iodine; radioiodine-refractory thyroid cancer; theranostics

(This special issue belongs to the Section Medical Research)

Stem Cell Biology, Tissue Formation, Cell Plasticity and Regenerative Medicine

edited by

Eustace Johnson

submission deadline 30 Nov 2026 | 4 articles | Viewed by 2671 | Submission Open

Keywords: stem cell biology; development and tissue formation; growth; tissue repair and regeneration; cell plasticity; model organisms and systems; clinical translation; regenerative medicine

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Nutrition, Exercise and Stress

edited by Maleah Holland-Winkler

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2447 | Submission Open

Keywords: nutrition; exercise; stress

(This special issue belongs to the Section Physiology and Pathology)

Advances in Diagnostic Management of Cardiovascular Diseases

edited by Carlo Gaudio,

Luigi Spadafora

and

Marco Bernardi

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2103 | Submission Open

Keywords: cardiovascular diagnostics; advanced imaging; biomarkers; artificial intelligence; risk stratification

(This special issue belongs to the Section Medical Research)

The Brain-Boosting Power of Exercise: Improving Cerebrovascular and Cognitive Health

edited by

Dean E. Mills

and

Edward Bliss

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1918 | Submission Open

Keywords: exercise; training; cerebrovascular; cognition; aerobic; resistance; multimodal

(This special issue belongs to the Section Physiology and Pathology)

Bioactive Phytotherapeutics in Metabolic and Inflammatory Disorders

edited by

Oana Cristina Şeremet

and

Octavian Tudorel Olaru

submission deadline 30 Nov 2026 | 3 articles | Viewed by 1912 | Submission Open

Keywords: phytotherapeutics; bioactive compounds; medicinal plants; metabolic disorders; inflammatory disorders; oxidative stress; chronic inflammation

(This special issue belongs to the Section Medical Research)

Structural Biology: Mechanisms, Technologies, and Insights

edited by

Mingliang Jin

Xiaoxuan Lin

and Hoa Nguyen

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1605 | Submission Open

Keywords: protein structure; allosteric regulation; protein dynamics; structure-guided therapeutics; structural methodology

(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)

Antibiotic Resistance in Biofilm: Mechanisms and Novel Interventions

edited by

Adriana Morar

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1597 | Submission Open

Keywords: biofilm; food industry; antimicrobial resistance; antibiotic resistance gene transfer; antibiofilm activity; control strategies

(This special issue belongs to the Section Microbiology)

Bronchiectasis: Advancing into the Future

edited by

Janice Wang

and Patricia A. Walker

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1560 | Submission Open

Keywords: non-CF bronchiectasis; NCFB; airway microbiome; non-tuberculous mycobacteria (NTM); biologics; endotypes; phenotypes; novel therapeutics; exacerbations

(This special issue belongs to the Section Medical Research)

Drug Safety and Outcomes in Respiratory and Critical Care Medicine

edited by

Josef Yayan

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1537 | Submission Open

Keywords: drug safety; adverse drug reactions; pharmacovigilance; critical care medicine; respiratory diseases; clinical outcomes; intensive care pharmacotherapy; drug–drug interactions

(This special issue belongs to the Section Pharmaceutical Science)

Physical Medicine and Rehabilitation: Trends and Applications—5th Edition

edited by

Li-Wei Chou

Jiunn-Horng Kang

Krisna Piravej

and Karen Sui Geok Chua

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1340 | Submission Open

Keywords: clinical physical medicine and rehabilitation; neurorehabilitation; cardiopulmonary rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; geriatric rehabilitation; cancer rehabilitation; musculoskeletal pain management; physical therapy; occupational therapy; speech and swallowing therapy

(This special issue belongs to the Section Epidemiology)

New Insights and Advances in Heart Failure Research

edited by Tzu-Hurng Cheng

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1337 | Submission Open

Keywords: cardiac remodeling; biomarkers; precision medicine; therapeutic innovations

(This special issue belongs to the Section Medical Research)

Pathophysiology and Treatments of Obesity

edited by

Francesco Saverio Latteri

, Andrea Peri and

Marcello Agosta

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1214 | Submission Open

Keywords: obesity; bariatric surgery; anti-obesity pharmacotherapy; gLP-1 receptor agonists; gut–brain axis; type 2 diabetes

(This special issue belongs to the Section Medical Research)

Cortical Development and Neurotransmission

edited by Christine Hohmann and Joanne Berger-Sweeney

submission deadline 30 Nov 2026 | 1 articles | Viewed by 952 | Submission Open

Keywords: cerebral cortex; neurotransmission; neuromodulatory neurotransmitters; developmental brain disorders; molecular mechanism

(This special issue belongs to the Section Medical Research)

Diagnosis and Therapeutics Approaches in Retinal Diseases

edited by

Jiro Kogo

and Yoshitsugu Matsui

submission deadline 30 Nov 2026 | 1 articles | Viewed by 765 | Submission Open

Keywords: retinal diseases; age-related macular degeneration (AMD); diabetic retinopathy; vitreoretinal; ophthalmology

(This special issue belongs to the Section Medical Research)

Recent Advances in Diagnostics, Monitoring and Management of Neonatal Diseases

edited by Minesh Khashu

submission deadline 30 Nov 2026 | 1 articles | Viewed by 764 | Submission Open

Keywords: newborn; neonate; neonatology; recent advances; diagnostics; monitoring; management; therapeutics

(This special issue belongs to the Section Medical Research)

Advances in the Diagnosis and Treatment of Liver Diseases

edited by

Nikolaos Machairas

and Georgios Sotiropoulos

submission deadline 30 Nov 2026 | 2 articles | Viewed by 711 | Submission Open

Keywords: liver diseases; hepatocellular carcinoma; molecular profiling; AI-assisted diagnostics

(This special issue belongs to the Section Medical Research)

Novel Insights into Musculoskeletal Disorders

edited by Giovanni Noia,

Michele Coviello

Giuseppe Rovere

and Andrea Fidanza

submission deadline 30 Nov 2026 | 1 articles | Viewed by 596 | Submission Open

Keywords: musculoskeletal disorders; diagnosis; therapeutics; regenerative medicine; intervention outcomes; orthopedic treatment

(This special issue belongs to the Section Medical Research)

Advances in Assessment and Treatment of Human Motor and Sensory Dysfunctions

edited by

Toshiaki Tanaka

and

Yusuke Maeda

submission deadline 30 Nov 2026 | 1 articles | Viewed by 575 | Submission Open

Keywords: motor control; sensorimotor integration; brain function; rehabilitation; balance and gait; robotic therapy; virtual reality; rehabilitation engineering

(This special issue belongs to the Section Physiology and Pathology)

Environmental Determinants of Cardiovascular Disease: Epigenetic Mechanisms and Genetic Interactions

edited by

Andrea Borghini

and

Francesca Gorini

submission deadline 30 Nov 2026 | 1 articles | Viewed by 501 | Submission Open

Keywords: cardiovascular disease; environmental exposure; genetics; epigenetics

(This special issue belongs to the Section Medical Research)

Fluid Management in Emergency and Intensive Care

edited by

Manu Malbrain

and

Prashant Nasa

submission deadline 30 Nov 2026 | Viewed by 460 | Submission Open

Keywords: fluids; fluid stewardship; resuscitation; shock

(This special issue belongs to the Section Medical Research)

Global Health in a Changing Climate: Interdisciplinary Perspectives on Human Well-Being

edited by Giuseppe Marano,

Marianna Mazza

, Gianandrea Traversi,

Eleonora Gaetani

and Esmeralda Capristo

submission deadline 30 Nov 2026 | Viewed by 445 | Submission Open

Keywords: climate change; global health; mental health; physical health; lifestyle interventions; cross-disciplinary research

(This special issue belongs to the Section Medical Research)

Musculoskeletal Diseases in Older Adults: Diagnosis, Treatment, and Management

edited by

Chun-Feng Huang

submission deadline 30 Nov 2026 | Viewed by 352 | Submission Open

Keywords: osteoporosis; sarcopenia; metabolic syndrome; precision medicine; older adults; frailty; metabolomics; fracture prevention

(This special issue belongs to the Section Medical Research)

From Environmental Exposure to Health Effects: Advances in Toxicology and Biomonitoring

edited by

Csilla Mišľanová

and

Martina Valachovičová

submission deadline 30 Nov 2026 | Viewed by 331 | Submission Open

Keywords: environmental contaminants; biomonitoring; toxicology; exposure assessment; biomarkers; flow cytometry; mechanisms of toxicity

(This special issue belongs to the Section Physiology and Pathology)

New Insights into Breast Cancer: Current Controversies and Future Perspectives, 2nd Edition

edited by

Alejandro Martin Sanchez

, Flavia de Lauretis and Chiara Valeria Pirrottina

submission deadline 30 Nov 2026 | Viewed by 305 | Submission Open

Keywords: breast cancer diagnosis; breast cancer treatment; breast cancer pathology; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies; targeted therapies; precision medicine

(This special issue belongs to the Section Medical Research)

Mitochondrial Transplantation: Therapeutic Strategies and Applications

edited by

Kei Hayashida

submission deadline 30 Nov 2026 | Viewed by 281 | Submission Open

Keywords: mitochondrial transplantation; mitochondrial therapy; bioenergetics; ischemia–reperfusion injury; immunometabolism; mitochondrial transfer; organ protection; translational medicine

(This special issue belongs to the Section Physiology and Pathology)

Cellular Inflammation and Regeneration: Mechanisms and Therapeutic Targets

edited by

Jea-Hyun Baek

submission deadline 30 Nov 2026 | Viewed by 234 | Submission Open

Keywords: resolution of inflammation; niche microenvironment; fibrosis; regenerative medicine

(This special issue belongs to the Section Physiology and Pathology)

Epidemiology of Pulmonology and Infectious Diseases

edited by

Josef Yayan

submission deadline 30 Nov 2026 | Viewed by 205 | Submission Open

Keywords: respiratory and infectious diseases; epidemiology; incidence and prevalence studies; risk factor analyses; outcome and prognostic studies; population-based cohorts; surveillance

(This special issue belongs to the Section Epidemiology)

Advances in Metabolism, Genetics and Breeding of Tea Tree

edited by Liyuan Wang

submission deadline 30 Nov 2026 | Viewed by 165 | Submission Open

Keywords: tea plant (Camellia sinensis); molecular mechanism; secondary metabolites; stress response; quality-related components; genetic identification; QTL mapping; molecular functional markers

(This special issue belongs to the Section Plant Science)

Molecular Signatures and Biomarkers in Human Diseases

edited by

Manuela Montanaro

and Alfonso Baldi

submission deadline 1 Dec 2026 | 1 articles | Viewed by 1161 | Submission Open

Keywords: biomarkers; therapeutic biomarkers; circulating biomarkers; molecular signatures; molecular imaging; precision medicine; targeted therapies; technological innovations

(This special issue belongs to the Section Medical Research)

The 15th Anniversary of Life: Endothelial Glycocalyx—a Determinant of Endothelial Function and Vascular Reactivity

edited by

Ines Drenjančević

submission deadline 11 Dec 2026 | 2 articles | Viewed by 4435 | Submission Open

Keywords: endothelial glycocalyx; cardiovascular system; oxidative stress; inflammation; nutrition

(This special issue belongs to the Section Physiology and Pathology)

Neurological Diseases: Prevention, Diagnostics, Treatment and Rehabilitation—2nd Edition

edited by

Constantin Munteanu

and

Gelu Onose

submission deadline 17 Dec 2026 | 5 articles | Viewed by 5980 | Submission Open

Keywords: neurological diseases; stroke prevention; stroke treatment; rehabilitation; artificial intelligence; cellular therapy; molecular therapy; interdisciplinary approaches; therapeutic interventions

(This special issue belongs to the Section Medical Research)

Plant Biotic and Abiotic Stresses 2026

edited by

Jie Luo

and

Gastón Pizzio

submission deadline 18 Dec 2026 | Viewed by 394 | Submission Open

Keywords: plant stress; abiotic stress; biotic stress

(This special issue belongs to the Section Plant Science)

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