Fluid Management in Emergency and Intensive Care
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 281
Special Issue Editors
Interests: critical care; less invasive (hemodynamic) and cardiac output monitoring; preload; intra-abdominal pressure measurement; fluid management; deresuscitation; Organ failure; respiratory failure; ARDS; renal failure; renal replacement therapy; abdominal hypertension; abdominal compartment syndrome; polycompartment syndrome
Special Issues, Collections and Topics in MDPI journals
Interests: airway; mechanical ventilation; IV fluids
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Intravenous (IV) fluid therapy, a cornerstone of emergency and critical care medicine, is paradoxically anchored in practice patterns that often outpace our foundational scientific understanding. While clinical trials have compared fluid types and strategies, significant knowledge gaps persist regarding the underlying pathophysiological mechanisms, the biological consequences of fluid administration, and how to precisely tailor therapy to an individual’s dynamic physiology. Moving beyond empirical “one-size-fits-all” approaches requires a deeper interrogation of the core science guiding fluid interventions.
This Special Issue seeks to shift the focus from purely clinical management debates to the fundamental science that must inform future precision fluid therapy. We invite original research, comprehensive reviews, and novel perspectives that illuminate the biological mechanisms, biomarker discovery, and bench-to-bedside integration essential for rational fluid management. We aim to curate contributions that explore the physiological and molecular landscape of fluid distribution, endothelial function, glycocalyx integrity, cellular edema, and organ-specific responses to fluid loading in critical illness.
Topics of interest include, but are not limited to, the following:
Pathophysiological Mechanisms: Investigative studies on endothelial dysfunction, vascular permeability, glycocalyx shedding, interstitial matrix interactions, and the role of inflammation in altering fluid kinetics.
Biomarker Discovery and Validation: Novel biomarkers (e.g., of endothelial damage, fluid tolerance, or tissue congestion) and their utility in predicting response, harm, or guiding therapy.
Translational and Integrative Physiology: Research bridging basic science models of fluid homeostasis with human pathophysiology, including the application of novel imaging or bioengineering techniques to assess fluid compartments.
Computational and “Omics” Approaches: Systems biology, pharmacodynamic modeling, genomics, or proteomics studies aimed at phenotyping patient-specific fluid responsiveness and vulnerability to fluid overload.
Cross-Disciplinary Insights: Innovations from fields such as bioengineering, biophysics, immunology, or pharmacology that provide new frameworks for understanding fluid dynamics in diseased states.
Our goal is to consolidate and stimulate cutting-edge science that moves the field from tradition-driven practice to mechanism-based, biomarker-informed paradigms for IV fluid management in critically ill and emergency department patients.
Prof. Dr. Manu Malbrain
Dr. Prashant Nasa
Guest Editors
Manuscript Submission Information
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Keywords
- fluids
- fluid stewardship
- resuscitation
- shock
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