Structural Biology: Mechanisms, Technologies, and Insights
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Biochemistry, Biophysics and Computational Biology".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 1061
Special Issue Editors
Interests: structural biology; conformational dynamics; cryo-EM; immune receptor signaling; antibody engineering
Interests: HDX-MS; thermodynamics; membrane proteins; ion channels
Special Issue Information
Dear Colleagues,
Understanding the relationship between protein structure and biological function remains central to modern life sciences. Recent advances in structural biology, particularly cryo-electron microscopy (cryo-EM), NMR spectroscopy, HDX-MS (Hydrogen/Deuterium Exchange Mass Spectrometry), and integrative methods, have offered unprecedented and detailed insights into protein dynamics and allosteric mechanisms. These tools reveal not only static snapshots but also conformational landscapes that underpin molecular recognition, signaling, and catalysis. In parallel, the integration of structural data with functional assays and computational modeling has greatly expanded the impact of the field.
This Special Issue aims to showcase cutting-edge research in structural biology and mechanistic discoveries and insights. We welcome original research articles, perspectives, and reviews that address fundamental principles or translational advances. Topics of interest include, but are not limited to, conformational dynamics, structure-guided drugs, antibody design, macromolecular assemblies, and new frontiers in cryo-EM, NMR, and HDX methodology.
By presenting recent trends and integrative approaches, this Special Issue will provide a timely resource for researchers across biochemistry, molecular biology, biophysics, and biomedical sciences.
Dr. Mingliang Jin
Guest Editor
Dr. Xiaoxuan Lin
Dr. Hoa Nguyen
Guest Editor Assistants
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protein structure
- allosteric regulation
- protein dynamics
- structure-guided therapeutics
- structural methodology
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