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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Prostate Cancer: 4th Edition

edited by

Paula Oliveira

and

Ana Faustino

submission deadline 30 Apr 2027 | 6 articles | Viewed by 11039 | Submission Open

Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling

(This special issue belongs to the Section Medical Research)

Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy

edited by Przemysław Kosinski

submission deadline 30 Apr 2027 | 5 articles | Viewed by 8881 | Submission Open

Keywords: fetal medicine; prenatal diagnosis; non-invasive prenatal testing (NIPT); fetal imaging; fetal therapy; fetal surgery; neonatal intensive care; genetic and genomic advances; perinatal outcomes; maternal-fetal health

(This special issue belongs to the Section Reproductive and Developmental Biology)

Mechanisms and Treatment of Eye and Vision Conditions

edited by Jeong-Min Hwang

submission deadline 30 Apr 2027 | 6 articles | Viewed by 4950 | Submission Open

Keywords: mechanism; treatment; eye; vision

(This special issue belongs to the Section Medical Research)

New Advances in the Treatment and Assessment of Temporomandibular Joint Disorders

edited by

Łukasz Rafał Pałka

submission deadline 30 Apr 2027 | 4 articles | Viewed by 4365 | Submission Open

Keywords: orofacial dysfunction; multifactorial etiology; advanced diagnostic technologies; biomechanical modeling of TMJ; novel imaging techniques; inflammatory and degenerative changes; interdisciplinary management; conservative therapy approaches; occlusal concepts; splint therapy design; physical therapy regimens; long-term implant treatment outcomes; personalized treatment strategies

(This special issue belongs to the Section Medical Research)

Research on Glaucoma Diseases

edited by

Nicoleta Anton

submission deadline 30 Apr 2027 | 2 articles | Viewed by 4029 | Submission Open

Keywords: glaucoma diseases; new technology; artificial intelligence in ophthalmology; gene therapy in glaucoma; new devices; artificial drainage systems

(This special issue belongs to the Section Medical Research)

Multi-Dimensional Mechanisms Underlying Crop Abiotic Stress Resistance

edited by

Zhenyuan Pan

submission deadline 30 Apr 2027 | Viewed by 295 | Submission Open

Keywords: abiotic stresses; physiological and metabolic responses; genetic and epigenetic mechanisms; biotechnological improvement strategies; germplasm innovation; cultivation management

(This special issue belongs to the Section Plant Science)

New Horizons: Biology and Pathology of Viruses in Animals

edited by Mayara Maggioli

submission deadline 30 Apr 2027 | Viewed by 246 | Submission Open

Keywords: animal viruses; viral pathogenesis; virus–host interactions; viral replication and cell entry; host immune responses to viral infection; transmission dynamics and disease severity; veterinary virology; emerging and zoonotic viruses; livestock and companion animal diseases; food security and animal health

(This special issue belongs to the Section Animal Science)

Nanocarriers for Inflammatory Skin Diseases and Beyond

edited by

Kanchan Kohli

, Nisha Sharma and

Sudhanshu Mishra

submission deadline 30 Apr 2027 | Viewed by 153 | Submission Open

Keywords: inflammatory skin diseases; nanocarriers; topical drug delivery; transdermal drug delivery; polymeric nanoparticles; liposomes; nanoemulsions; nanogels; micelles

(This special issue belongs to the Section Pharmaceutical Science)

Bioactive Compounds from Natural Products and Functional Food Development

edited by

Simona Ioana Vicas

and

Cristina Adriana Rosan

submission deadline 30 Apr 2027 | Viewed by 137 | Submission Open

Keywords: bioactive plant compounds; phytochemistry; plant secondary metabolites; plant extracts; natural antioxidants; biological activities; functional foods; nutraceuticals; green extraction techniques; sustainable valorization of plant resources

(This special issue belongs to the Section Plant Science)

Ferroptosis in Human Disease: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

edited by Prem Prakash Kushwaha, Alok Kumar and

Ankit Kushwaha

submission deadline 30 Apr 2027 | Viewed by 123 | Submission Open

Keywords: ferroptosis; iron metabolism; lipid peroxidation; mitochondrial dysfunction; glutathione metabolism

(This special issue belongs to the Section Physiology and Pathology)

Research Update in Myopia Complications

edited by

Nicoleta Anton

submission deadline 30 Apr 2027 | Viewed by 86 | Submission Open

Keywords: myopia; retinal detachment; myopic macular degeneration (MMD); glaucoma; cataracts; artificial intelligence

(This special issue belongs to the Section Medical Research)

Microvascular Dynamics, Architecture, and Function

edited by

Aristotle G. Koutsiaris

and Friedrich Jung

submission deadline 30 Apr 2027 | Viewed by 83 | Submission Open

Keywords: microvessels; dynamics; velocity; flow; rheology; in vitro; animals; humans; biomarkers; imaging; simulations; models; preclinical; clinical; microvascular topology; microvascular architecture; microvascular structure; microvascular function

(This special issue belongs to the Section Physiology and Pathology)

New Insights into Biomaterials-Assisted Bioremediation: Plant, Animal and Microbial Perspectives

edited by

Mikael Motelica-Heino

submission deadline 30 Apr 2027 | Viewed by 71 | Submission Open

Keywords: environmental remediation; heavy metal pollution; persistent organic pollutants (POPs)/recalcitrant organics; nanomaterials/engineered nanomaterials; biomass-derived materials; bioremediation; phytoremediation; microbial remediation; zooremediation; green remediation technology

(This special issue belongs to the Section Life Sciences)

Progress in Hemorrhage Control and Blood Transfusion in Trauma

edited by

Henry Peng

and

Jeffrey Anderson

submission deadline 30 Apr 2027 | Viewed by 66 | Submission Open

Keywords: artificial intelligence; blood products; blood transfusion; hemostatic agents; hemorrhage control; hemostatic materials; hemostatic resuscitation; trauma coagulopathy; viscoelastic hemostatic assays

(This special issue belongs to the Section Medical Research)

Chronic Inflammatory Skin Diseases: Epidemiology, Diagnosis, Treatment

edited by

Ricardo Ruiz-Villaverde

submission deadline 30 Apr 2027 | Viewed by 56 | Submission Open

Keywords: psoriasis; atopic dermatitis; hidradenitis suppurativa; chronic urticaria; precision medicine; biologic therapies; biomarkers; real-world evidence; translational dermatology

(This special issue belongs to the Section Medical Research)

Utilization of Pharmacogenomics in Clinical Practice

edited by Vijayaprakash Suppiah

submission deadline 30 Apr 2027 | Viewed by 49 | Submission Open

Keywords: pharmacogenomics; genetics; clinical practice; multimorbidity; chronic conditions; pharmacology

(This special issue belongs to the Section Pharmaceutical Science)

Pharmacy Research: Epidemiology, Disease Intervention, Efficacy and Safety

edited by

Seungyeon Kim

submission deadline 30 Apr 2027 | Viewed by 30 | Submission Open

Keywords: clinical pharmacy; pharmacoepidemiology; real-world evidence; drug safety; drug utilization; comparative effectiveness; precision medicine; pharmacovigilance; artificial intelligence

(This special issue belongs to the Section Pharmaceutical Science)

Current Perspectives on Dysphagia

edited by

Ji-Youn Kim

submission deadline 1 May 2027 | Viewed by 26 | Submission Open

Keywords: dysphagia; swallowing diagnosis and assessment; diagnostic imaging; swallowing rehabilitation; swallowing physiology; swallowing pathophysiology

(This special issue belongs to the Section Medical Research)

Fascial Dysfunction and Myofascial Pain: Pathophysiology, Diagnosis and Management

edited by

Antonio Stecco

submission deadline 15 May 2027 | Viewed by 22 | Submission Open

Keywords: fascia; muscle stiffness and alteration of the connective tissue; spasticity Avatar

(This special issue belongs to the Section Medical Research)

Advances in Plant Adaptation to Environmental Stress Through Molecular, Physiological, Systems Biology, and Omics Perspectives

edited by Mohammad Mizanur Rahman,

Takashi Asaeda

and

M. Harun Rashid

submission deadline 17 May 2027 | Viewed by 42 | Submission Open

Keywords: plant adaptation; environmental stress; abiotic stress; molecular biology; plant physiology; systems biology; multi-omics; stress signaling; gene regulation; crop resilience

(This special issue belongs to the Section Plant Science)

Human Infertility and Reproductive Endocrinology: 3rd Edition

edited by

Giuseppe Grande

submission deadline 26 May 2027 | Viewed by 29 | Submission Open

Keywords: infertility; reproduction; reproductive endocrinology; male infertility; female infertility

(This special issue belongs to the Section Reproductive and Developmental Biology)

Effects of Environmental Factors on Challenges of Plant Breeding: 2nd Edition

edited by

Katalin Magyar-Tábori

and

Nóra Mendler-Drienyovszki

submission deadline 31 May 2027 | 1 articles | Viewed by 4063 | Submission Open

Keywords: plant breeding; winter hardiness; sowing time; adaptation to cold/frost; physiology of cold/frost tolerance; snow cover

(This special issue belongs to the Section Plant Science)

Skin Care and Innovation from the Perspective of Molecular Dermatology

edited by

Ewa Markiewicz

Olusola Idowu

and

Jacek C. Szepietowski

submission deadline 31 May 2027 | 1 articles | Viewed by 1931 | Submission Open

Keywords: molecular dermatology; personalised skincare; ageing; natural ingredients

(This special issue belongs to the Section Physiology and Pathology)

Innovations in Nuclear Medicine and Molecular Imaging

edited by

Christian Kühnel

and

Yiannis Parpottas

submission deadline 31 May 2027 | 1 articles | Viewed by 1444 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; SPECT; radiopharmaceuticals; theranostics; quantitative imaging; artificial intelligence; dosimetry; precision medicine

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research—3rd Edition

edited by

Dan Mircea Olinic

and

Agata Stanek

submission deadline 31 May 2027 | 1 articles | Viewed by 1159 | Submission Open

Keywords: vascular diseases; etiology; diagnosis; prognosis; therapy

(This special issue belongs to the Section Medical Research)

Omics Approaches in Antipsychotic Pharmacology

edited by

Kyle Burghardt

submission deadline 31 May 2027 | Viewed by 438 | Submission Open

Keywords: antipsychotics; genomics; epigenomics; transcriptomics; lipidomics; metabolomics; proteomics; human; animal

(This special issue belongs to the Section Pharmaceutical Science)

Anti-Inflammatory and Natural Products

edited by

Chi-Su Yoon

submission deadline 31 May 2027 | Viewed by 431 | Submission Open

Keywords: anti-inflammation; macrophage; mechanism study; in vivo/in vitro model; natural products; natural products-derived compound

(This special issue belongs to the Section Pharmaceutical Science)

Contemporary Therapeutic Strategies for Solid Tumors: 2nd Edition

edited by Chohao Lee

submission deadline 31 May 2027 | Viewed by 49 | Submission Open

Keywords: solid tumors; therapeutic strategies; targeted therapy; immunotherapy; precision medicine; survival analysis; real-world evidence; treatment resistance; prognostic factors

(This special issue belongs to the Section Medical Research)

Monitoring, Diagnosis and Treatment in Neurocritical Care

edited by

Gabriele Melegari

submission deadline 31 May 2027 | Viewed by 27 | Submission Open

Keywords: neurocritical care; acute brain injury; neuromonitoring; neuroprognostication; biomarkers; neuroimaging; secondary brain injury; disorders of consciousness; end-of-life care; precision medicine

(This special issue belongs to the Section Medical Research)

AI-Driven Bioinformatics and Multi-Omics for Precision Medicine

edited by

Ravindra Kumar

and Rajrani Ruhel

submission deadline 31 May 2027 | Viewed by 15 | Submission Open

Keywords: bioinformatics; artificial intelligence; machine learning; multi-omics; biomarkers discovery; precision medicine

(This special issue belongs to the Section Artificial Intelligence in the Life Sciences)

Advances in Diagnosis and Treatment of Neurocognitive Disorders

edited by Wei Li

submission deadline 31 May 2027 | Viewed by 4 | Submission Open

Keywords: Alzheimer’s disease; Parkinson’ disease; traumatic brain injury; stroke; transient ischemic attack; substance use disorder; diabetes; cognitive impairment; dementia; mild cognitive impairment

(This special issue belongs to the Section Medical Research)

Update on Metabolites Bioactives

edited by

Eduardo Jacob-Lopes

Leila Queiroz Zepka

and Tatiele Casagrande do Nascimento

submission deadline 25 Jun 2027 | Viewed by 248 | Submission Open

Keywords: microalgae; one health; bioactive compounds; artificial intelligence; gut microbiota; metabolism; functional foods; precision nutrition; sustainability; disease prevention

(This special issue belongs to the Section Microbiology)

Ophthalmologic Diseases: From Molecules and Molecular Mechanisms to Therapeutics

edited by

Soo-Young Kim

and

Dong Hui Lim

submission deadline 30 Jun 2027 | 1 articles | Viewed by 733 | Submission Open

Keywords: retinal disease; corneal disease; genetic diseases; inflammatory diseases; ocular diseases; ocular drug development

(This special issue belongs to the Section Physiology and Pathology)

Pharmacology and Emerging Therapeutics for Lung Disorders

edited by

Jagdish Joshi

submission deadline 30 Jun 2027 | Viewed by 44 | Submission Open

Keywords: lung infectious injury; ARDS; asthma; COPD; interstitial lung fibrosis; cystic fibrosis; tuberculosis; pulmonary hypertension; pulmonary drug delivery

(This special issue belongs to the Section Pharmaceutical Science)

Heatwaves, Emerging Pollutants, and Human Health: Bridging Thermal Physiology and Public Health Epidemiology

edited by

Faming Wang

and Tze-Huan Lei

submission deadline 30 Jun 2027 | Viewed by 24 | Submission Open

Keywords: heat stress; air pollution; synergistic effects; thermoregulation; oxidative stress; emerging contaminants; climate change; molecular toxicology; cardiovascular physiology; biomarkers

(This special issue belongs to the Section Epidemiology)

Biotic and Abiotic Stress in Woody Plants

edited by

and

submission deadline 1 Jul 2027 | 1 articles | Viewed by 370 | Submission Open

Keywords: woody plant; climate change; biotic stress; abiotic stress; non-coding RNAs; CRISPR/Cas9; plant physiology; molecular networks; genomics; metabolomics

(This special issue belongs to the Section Plant Science)

New Insights into Aquatic Animal Nutrition and Genomic Breeding

edited by Qincheng Huang and Jilun Meng

submission deadline 15 Jul 2027 | Viewed by 185 | Submission Open

Keywords: aquatic animals; nutrition regulation; genomic breeding; aquaculture; nutritional traits; molecular breeding; germplasm improvement; precision feeding

(This special issue belongs to the Section Animal Science)

Biological and Therapeutic Advances in B-Cell Malignancies

edited by Magdalena Witkowska

submission deadline 31 Jul 2027 | Viewed by 1 | Submission Open

Keywords: B-cell malignant disease; B-cell lymphoma; Hodgkin lymphoma; DLBCL; Follicular lymphoma

(This special issue belongs to the Section Medical Research)

Interdisciplinary Innovation of AI-Driven Smart Agriculture

edited by

Wei Zhan

Weiwei Zhang

and Qincheng Huang

submission deadline 15 Aug 2027 | Viewed by 73 | Submission Open

Keywords: AI-driven smart agriculture; interdisciplinary integration; precision breeding; sustainable agro-biology; agricultural multi-omics

(This special issue belongs to the Section Artificial Intelligence in the Life Sciences)

Research Updates in Hypertension: Pathophysiology, Comorbidities, and Treatment

edited by Panagiota Anyfanti and

Eleni Karlafti

submission deadline 30 Aug 2027 | Viewed by 76 | Submission Open

Keywords: hypertension; blood pressure; cardiovascular risk; hypertension-mediated organ damage; arterial stiffness; vascular aging; cardiometabolic disease; endothelial dysfunction; precision medicine; antihypertensive therapy

(This special issue belongs to the Section Medical Research)

Poultry Nutrition and Gut Microbiota Health

edited by

Ala Abudabos

submission deadline 31 Aug 2027 | 1 articles | Viewed by 447 | Submission Open

Keywords: gut health; microbiota; necrotic enteritis; coccidiosis; immunity; poultry; natural additives

(This special issue belongs to the Section Animal Science)

New Insights into Occupational Medicine and Molecular Pathology

edited by

Roberto Zefferino

and

Massimo Conese

submission deadline 31 Aug 2027 | Viewed by 11 | Submission Open

Keywords: biological markers of stress; tumor microenvironment; job stress; stress signal transduction pathways; mental disorders; carcinogenesis

(This special issue belongs to the Section Medical Research)

Molecular Regulation of Lipid Metabolism in Fish: Nutrient Modulation, Environmental Perturbation and Therapeutic Targets

edited by Yihuan Xu,

Lihan Zhang

and Xin Zhao

submission deadline 31 Dec 2027 | Viewed by 93 | Submission Open

Keywords: lipid metabolism; fish; molecular regulation; nutrient modulation

(This special issue belongs to the Section Animal Science)

Emerging Therapeutic Strategies for Fibrosis: From Molecular Mechanisms to Drug Discovery

edited by Hui-Chun Ku and Shih-Yi Lee

submission deadline 31 Dec 2027 | Viewed by 89 | Submission Open

Keywords: fibrosis; drug discovery; therapeutic strategies; inflammation; oxidative stress; extracellular matrix remodeling; fibrosis signaling pathways; biomarkers; natural products; small-molecule therapeutics

(This special issue belongs to the Section Physiology and Pathology)

Novel Therapeutics for Musculoskeletal Disorders—2nd Edition

edited by