Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Physical Medicine and Rehabilitation: Trends and Applications—5th Edition
edited by , , and Karen Sui Geok Chua
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1291 | Submission Open
Keywords: clinical physical medicine and rehabilitation; neurorehabilitation; cardiopulmonary rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; geriatric rehabilitation; cancer rehabilitation; musculoskeletal pain management; physical therapy; occupational therapy; speech and swallowing therapy
(This special issue belongs to the Section Epidemiology)
New Insights and Advances in Heart Failure Research
edited by Tzu-Hurng Cheng
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1233 | Submission Open
Keywords: cardiac remodeling; biomarkers; precision medicine; therapeutic innovations
(This special issue belongs to the Section Medical Research)
Pathophysiology and Treatments of Obesity
edited by , Andrea Peri and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1179 | Submission Open
Keywords: obesity; bariatric surgery; anti-obesity pharmacotherapy; gLP-1 receptor agonists; gut–brain axis; type 2 diabetes
(This special issue belongs to the Section Medical Research)
Cortical Development and Neurotransmission
edited by Christine Hohmann and Joanne Berger-Sweeney
submission deadline 30 Nov 2026 | 1 articles | Viewed by 923 | Submission Open
Keywords: cerebral cortex; neurotransmission; neuromodulatory neurotransmitters; developmental brain disorders; molecular mechanism
(This special issue belongs to the Section Medical Research)
Diagnosis and Therapeutics Approaches in Retinal Diseases
edited by and Yoshitsugu Matsui
submission deadline 30 Nov 2026 | 1 articles | Viewed by 746 | Submission Open
Keywords: retinal diseases; age-related macular degeneration (AMD); diabetic retinopathy; vitreoretinal; ophthalmology
(This special issue belongs to the Section Medical Research)
Recent Advances in Diagnostics, Monitoring and Management of Neonatal Diseases
edited by Minesh Khashu
submission deadline 30 Nov 2026 | 1 articles | Viewed by 723 | Submission Open
Keywords: newborn; neonate; neonatology; recent advances; diagnostics; monitoring; management; therapeutics
(This special issue belongs to the Section Medical Research)
Novel Insights into Musculoskeletal Disorders
edited by Giovanni Noia, , and Andrea Fidanza
submission deadline 30 Nov 2026 | 1 articles | Viewed by 548 | Submission Open
Keywords: musculoskeletal disorders; diagnosis; therapeutics; regenerative medicine; intervention outcomes; orthopedic treatment
(This special issue belongs to the Section Medical Research)
Advances in Assessment and Treatment of Human Motor and Sensory Dysfunctions submission deadline 30 Nov 2026 | 1 articles | Viewed by 519 | Submission Open
Keywords: motor control; sensorimotor integration; brain function; rehabilitation; balance and gait; robotic therapy; virtual reality; rehabilitation engineering
(This special issue belongs to the Section Physiology and Pathology)
Fluid Management in Emergency and Intensive Care submission deadline 30 Nov 2026 | Viewed by 446 | Submission Open
Keywords: fluids; fluid stewardship; resuscitation; shock
(This special issue belongs to the Section Medical Research)
Global Health in a Changing Climate: Interdisciplinary Perspectives on Human Well-Being
edited by Giuseppe Marano, , Gianandrea Traversi, and Esmeralda Capristo
submission deadline 30 Nov 2026 | Viewed by 432 | Submission Open
Keywords: climate change; global health; mental health; physical health; lifestyle interventions; cross-disciplinary research
(This special issue belongs to the Section Medical Research)
Advances in the Diagnosis and Treatment of Liver Diseases
edited by and Georgios Sotiropoulos
submission deadline 30 Nov 2026 | 2 articles | Viewed by 356 | Submission Open
Keywords: liver diseases; hepatocellular carcinoma; molecular profiling; AI-assisted diagnostics
(This special issue belongs to the Section Medical Research)
Musculoskeletal Diseases in Older Adults: Diagnosis, Treatment, and Management
edited by
submission deadline 30 Nov 2026 | Viewed by 343 | Submission Open
Keywords: osteoporosis; sarcopenia; metabolic syndrome; precision medicine; older adults; frailty; metabolomics; fracture prevention
(This special issue belongs to the Section Medical Research)
From Environmental Exposure to Health Effects: Advances in Toxicology and Biomonitoring submission deadline 30 Nov 2026 | Viewed by 321 | Submission Open
Keywords: environmental contaminants; biomonitoring; toxicology; exposure assessment; biomarkers; flow cytometry; mechanisms of toxicity
(This special issue belongs to the Section Physiology and Pathology)
Environmental Determinants of Cardiovascular Disease: Epigenetic Mechanisms and Genetic Interactions submission deadline 30 Nov 2026 | Viewed by 305 | Submission Open
Keywords: cardiovascular disease; environmental exposure; genetics; epigenetics
(This special issue belongs to the Section Medical Research)
New Insights into Breast Cancer: Current Controversies and Future Perspectives, 2nd Edition
edited by , Flavia de Lauretis and Chiara Valeria Pirrottina
submission deadline 30 Nov 2026 | Viewed by 292 | Submission Open
Keywords: breast cancer diagnosis; breast cancer treatment; breast cancer pathology; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies; targeted therapies; precision medicine
(This special issue belongs to the Section Medical Research)
Mitochondrial Transplantation: Therapeutic Strategies and Applications
edited by
submission deadline 30 Nov 2026 | Viewed by 266 | Submission Open
Keywords: mitochondrial transplantation; mitochondrial therapy; bioenergetics; ischemia–reperfusion injury; immunometabolism; mitochondrial transfer; organ protection; translational medicine
(This special issue belongs to the Section Physiology and Pathology)
Cellular Inflammation and Regeneration: Mechanisms and Therapeutic Targets
edited by
submission deadline 30 Nov 2026 | Viewed by 223 | Submission Open
Keywords: resolution of inflammation; niche microenvironment; fibrosis; regenerative medicine
(This special issue belongs to the Section Physiology and Pathology)
Epidemiology of Pulmonology and Infectious Diseases
edited by
submission deadline 30 Nov 2026 | Viewed by 198 | Submission Open
Keywords: respiratory and infectious diseases; epidemiology; incidence and prevalence studies; risk factor analyses; outcome and prognostic studies; population-based cohorts; surveillance
(This special issue belongs to the Section Epidemiology)
Advances in Metabolism, Genetics and Breeding of Tea Tree
edited by Liyuan Wang
submission deadline 30 Nov 2026 | Viewed by 159 | Submission Open
Keywords: tea plant (Camellia sinensis); molecular mechanism; secondary metabolites; stress response; quality-related components; genetic identification; QTL mapping; molecular functional markers
(This special issue belongs to the Section Plant Science)
Molecular Signatures and Biomarkers in Human Diseases
edited by and Alfonso Baldi
submission deadline 1 Dec 2026 | 1 articles | Viewed by 1124 | Submission Open
Keywords: biomarkers; therapeutic biomarkers; circulating biomarkers; molecular signatures; molecular imaging; precision medicine; targeted therapies; technological innovations
(This special issue belongs to the Section Medical Research)
The 15th Anniversary of Life: Endothelial Glycocalyx—a Determinant of Endothelial Function and Vascular Reactivity submission deadline 11 Dec 2026 | 2 articles | Viewed by 4239 | Submission Open
Keywords: endothelial glycocalyx; cardiovascular system; oxidative stress; inflammation; nutrition
(This special issue belongs to the Section Physiology and Pathology)
Neurological Diseases: Prevention, Diagnostics, Treatment and Rehabilitation—2nd Edition submission deadline 17 Dec 2026 | 5 articles | Viewed by 5735 | Submission Open
Keywords: neurological diseases; stroke prevention; stroke treatment; rehabilitation; artificial intelligence; cellular therapy; molecular therapy; interdisciplinary approaches; therapeutic interventions
(This special issue belongs to the Section Medical Research)
Plant Biotic and Abiotic Stresses 2026
edited by and
submission deadline 18 Dec 2026 | Viewed by 389 | Submission Open
Keywords: plant stress; abiotic stress; biotic stress
(This special issue belongs to the Section Plant Science)
Towards Resilient Seas: Marine Biodiversity and Ecological Functioning in a Changing Ocean
edited by and Dorka Cobián-Rojas
submission deadline 20 Dec 2026 | 2 articles | Viewed by 2681 | Submission Open
Keywords: marine conservation; ecosystem-based management; biodiversity; climate change adaptation; restoration process; ecological connectivity
(This special issue belongs to the Section Biodiversity, Ecology and Evolution)
Carbohydrate Malabsorption: Microbial Crosstalk, Underlying Mechanisms and Personalized Interventions
edited by and Ana S. Sousa
submission deadline 20 Dec 2026 | 1 articles | Viewed by 993 | Submission Open
Keywords: carbohydrate malabsorption; gut microbiota; personalized intervention; nutrition; fructose; lactose; polyols
(This special issue belongs to the Section Microbiology)
Multifaceted Role of Tryptophan-Kynurenine Pathway in Metabolism and Human Health: From Molecular Targets to Therapeutic Interventions submission deadline 20 Dec 2026 | 1 articles | Viewed by 664 | Submission Open
Keywords: amino acids; biomarkers; immunomodulation; metabolic disease; neuroprotection; psychopharmacology; aging; gut-brain axis; cardiovascular; renal
(This special issue belongs to the Section Physiology and Pathology)
Brain Disease Diagnosis and Image Recognition
edited by Shumao Xu, and Minyan Ge
submission deadline 20 Dec 2026 | Viewed by 467 | Submission Open
Keywords: artificial intelligence; brain disease diagnosis; medical image recognition; neuroimaging; computational neuroscience; deep learning; machine learning; computer vision; signal processing; biomedical image analysis; neurodegenerative disorders; brain–computer interface; sleep disorders; sleep–wake regulation; polysomnography (PSG) analysis; circadian rhythms; sleep staging automation; REM sleep detection; insomnia biomarker identification; sleep apnea detection; neuroinflammation imaging; multimodal data fusion; explainable AI (XAI); federated learning; generative adversarial networks (GANs); edge computing for healthcare; clinical decision support systems; precision neurology; biomarker discovery; sleep-related neurodegeneration; EEG signal processing; functional MRI (fMRI); diffusion tensor imaging (DTI); Alzheimer’s disease prediction; Parkinson’s disease biomarkers; brain tumor segmentation; stroke lesion mapping; ethical AI in healthcare; AI-driven sleep medicine; automated sleep scoring
Advances in Computational and Spatial Pathology
edited by
submission deadline 20 Dec 2026 | Viewed by 390 | Submission Open
Keywords: computational pathology; spatial pathology; spatial transcriptomics; spatial proteomics; digital pathology; whole-slide imaging; deep learning; machine learning; tumor microenvironment; tissue architecture; multiplexed imaging; biomarker discovery; multimodal data integration
(This special issue belongs to the Section Physiology and Pathology)
Advances in Livestock Breeding, Nutrition and Metabolism
edited by
submission deadline 30 Dec 2026 | 3 articles | Viewed by 7129 | Submission Open
Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability
(This special issue belongs to the Section Animal Science)
Recent Advances in Crop Genetics and Breeding: 2nd Edition
edited by , , and Long Chen
submission deadline 30 Dec 2026 | Viewed by 1225 | Submission Open
Keywords: crop; high-throughput genotyping; genetic resources; favorable haplotype; marker-assisted selection; genome editing; CRISPR-Cas9; genomic selection
(This special issue belongs to the Section Plant Science)
Genetics and Genomics in Human Health and Disease
edited by and Amelia Dobrescu
submission deadline 30 Dec 2026 | 1 articles | Viewed by 697 | Submission Open
Keywords: genetics; genomics; clinical genetics
(This special issue belongs to the Section Genomics and Proteomics)
Kidney Disease: From Pathophysiology to Personalized Approaches
edited by and Venelin Mitov
submission deadline 30 Dec 2026 | Viewed by 390 | Submission Open
Keywords: kidney disease; omics; biomarkers; cellular crosstalk; transcriptomics; spatial omics; renal fibrosis
(This special issue belongs to the Section Physiology and Pathology)
Novel Insights into Chronic Pain: Pathophysiology and Interventions
edited by Jung Eun Kim and
submission deadline 30 Dec 2026 | Viewed by 296 | Submission Open
Keywords: chronic pain; pathophysiology; interventions; neuroinflammation; central sensitization; pharmacological therapy; sarcopenia; interventional pain management
(This special issue belongs to the Section Medical Research)
Novel Insights into Environmental Agents' Toxicity and Therapeutic Strategies
edited by and Paula Moyano
submission deadline 30 Dec 2026 | Viewed by 282 | Submission Open
Keywords: environmental toxicology; molecular mechanisms of toxicity; therapeutic interventions; exposome; endocrine disruptors; biomonitoring
(This special issue belongs to the Section Pharmaceutical Science)
New Insights into Cell Death Mechanisms and Multi-Omics in Cancer
edited by Yu-Guang Chen
submission deadline 30 Dec 2026 | Viewed by 184 | Submission Open
Keywords: cell death; apoptosis; ferroptosis; pyroptosis; necroptosis; cuproptosis; autophagy; multi-omics; genomics; transcriptomics; proteomics; cancer; tumor microenvironment; biomarkers; immunotherapy; liquid biopsy; single-cell sequencing; drug resistance
(This special issue belongs to the Section Physiology and Pathology)
Recent Insights in the Pathogenesis, Diagnosis, Prognosis and Treatment of Glomerular Disorders submission deadline 31 Dec 2026 | 8 articles | Viewed by 27346 | Submission Open
Keywords: glomerular disorders; pathology; kidney biopsy; immunology; immunosuppresion; vasculitis
(This special issue belongs to the Section Medical Research)
Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition submission deadline 31 Dec 2026 | 11 articles | Viewed by 19234 | Submission Open
Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases
(This special issue belongs to the Section Physiology and Pathology)
Vision Science and Optometry: 2nd Edition submission deadline 31 Dec 2026 | 9 articles | Viewed by 12740 | Submission Open
Keywords: clinical optometry; eye movements and binocular vision; aberrometry; accommodation; color vision; anterior and posterior pole; circadian light
(This special issue belongs to the Section Medical Research)
Therapeutic Innovations from Plants and Their Bioactive Extracts
edited by and Annamária Pallag
submission deadline 31 Dec 2026 | 9 articles | Viewed by 11525 | Submission Open
Keywords: herbals; plant extracts; phytochemicals; polyphenols; anthocyanins; natural compounds isolation; herbal extract characterization; bioactive extracts preparation; oxidative stress; apoptosis; inflammation; dermatitis; psoriasis; diabetes mellitus; neurodegenerative disorders; CNS diseases; new target molecules; animal models; clinical studies
(This special issue belongs to the Section Pharmaceutical Science)
Advanced Machine Learning for Disease Prediction and Prevention
edited by and
submission deadline 31 Dec 2026 | 6 articles | Viewed by 11351 | Submission Open
Keywords: advanced machine learning; disease prediction; disease prevention; biomedical data integration; multimodal data; explainable AI (XAI); AI Interpretability; algorithmic fairness; bias mitigation; predictive modeling; healthcare analytics; risk stratification; early disease detection; clinical decision support; computational health; public health informatics; AI ethics in healthcare; medical AI validation; health data science; personalized medicine
(This special issue belongs to the Section Medical Research)
Effects of Exercise Training on Muscle Function—2nd Edition
edited by and
submission deadline 31 Dec 2026 | 3 articles | Viewed by 9371 | Submission Open
Keywords: exercise; training; muscle function; resistance training; HIIT
(This special issue belongs to the Section Physiology and Pathology)
The 15th Anniversary of Life—New Trends in Animal Health Science
edited by
submission deadline 31 Dec 2026 | 5 articles | Viewed by 8465 | Submission Open
Keywords: animal health science; animal disease; veterinary; animal nutrition; genetics, breeding and reproduction; One Health
(This special issue belongs to the Section Animal Science)
The Microbiome and Dysbiosis in Various Pathologies submission deadline 31 Dec 2026 | 7 articles | Viewed by 7910 | Submission Open
Keywords: metabolic diseases (obesity, type 2 diabetes, insulin resistance, metabolic syndrome, etc.); cardiovascular diseases (atherosclerosis, hypertension, etc.); dermatological diseases (acne, eczema, psoriasis, rosacea); autoimmune and inflammatory diseases (rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Hashimoto’s thyroiditis, etc.); digestive disorders (irritable bowel syndrome, inflammatory bowel disease: Crohn’s disease and ulcerative colitis, celiac disease, lactose intolerance and other food intolerances, gastritis, helicobacter pylori infections, etc.); neurological and psychiatric disorders (Parkinson’s and Alzheimer’s disease, depression, anxiety, autism); recurrent infections and low immunity; cancer (colorectal, gastric, esophageal, hepatic, pancreatic, breast, pulmonary, etc.); biochemical, genetic and epigenetic biomarkers; computational analysis
(This special issue belongs to the Section Microbiology)
Precision Medicine in Heart Failure: From Biomarkers to Targeted Therapies
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 5970 | Submission Open
Keywords: heart failure; precision medicine; biomarkers; multi-omics; personalized therapy; cardiovascular imaging; genetic profiling; artificial intelligence; risk stratification; targeted therapies
(This special issue belongs to the Section Medical Research)
Developmental Programming in Cats and Dogs
edited by , and Sylvie Chastant
submission deadline 31 Dec 2026 | 3 articles | Viewed by 5927 | Submission Open
Keywords: dog; cat; growth; health; prevention; development; susceptibility; environment; risk factors; nutrition; neutering
(This special issue belongs to the Section Animal Science)
From Animal Models to Clinical Innovations: Translating Research into Medicine submission deadline 31 Dec 2026 | 4 articles | Viewed by 5797 | Submission Open
Keywords: animal models; animal research; biomedical research; ethics of animal experimentation; experimentation on animals; interspecies differences; translational medicine; human clinical medicine
(This special issue belongs to the Section Animal Science)
Physiological Responses and Adaptation Mechanisms of Plants to Stress
edited by and Bassam T. Yasseen
submission deadline 31 Dec 2026 | 3 articles | Viewed by 5715 | Submission Open
Keywords: biotechnology; chemical composition; growth processes; heavy metals; hormonal balance; improving growth variables; mechanisms of osmotic stress; pollution; photosynthesis; stomatal behaviors
(This special issue belongs to the Section Plant Science)
Minimally Invasive and Transcatheter Interventions in Valvular Heart Disease
edited by
submission deadline 31 Dec 2026 | 5 articles | Viewed by 4630 | Submission Open
Keywords: transcatheter aortic valve replacement; minimally invasive cardiac surgery; aortic valve interventions; structural heart disease; valve repair outcomes
(This special issue belongs to the Section Medical Research)
Advances in the Epidemiology, Physiology, Diagnosis and Treatment of Breast Cancer
edited by , Traian Pǎtraşcu, Petronel Mustatea and
submission deadline 31 Dec 2026 | 4 articles | Viewed by 4130 | Submission Open
Keywords: epidemiology; physiology; conservative breast surgery; sentinel lymph node biopsy; artificial intelligence in breast cancer
(This special issue belongs to the Section Medical Research)
The 15th Anniversary of Life—Alternatives to RNA World
edited by and Amit Kahana
submission deadline 31 Dec 2026 | 2 articles | Viewed by 3488 | Submission Open
Keywords: supramolecular; lipid; assembly; protocell; compositional; information; spontaneous; catalytic; network; reproduction; species; Darwinian; evolution; origin; life
(This special issue belongs to the Section Origins of Life)
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