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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Decoding Hematologic Malignancies by Clinical Cytometry: From Diagnosis to Precision Medicine

edited by Yijie Liu and Huanbin Zhao

submission deadline 28 Feb 2026 | Viewed by 215 | Submission Open

Keywords: hematologic malignancies; diagnostic advancements; minimal/measurable residual disease (MRD) monitoring; emerging technologies; translational applications

(This special issue belongs to the Section Medical Research)

Structural Biology: Mechanisms, Technologies, and Insights

edited by

Mingliang Jin

Xiaoxuan Lin

and Hoa Nguyen

submission deadline 28 Feb 2026 | Viewed by 182 | Submission Open

Keywords: protein structure; allosteric regulation; protein dynamics; structure-guided therapeutics; structural methodology

(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)

Neuromodulation and Motor Skill Enhancement: Prospective Applications

edited by

Zachary Riley

and Davin R. Greenwell

submission deadline 28 Feb 2026 | Viewed by 145 | Submission Open

Keywords: non-invasive brain stimulation; tDCS; tACS; neuroplasticity; motor skill learning

(This special issue belongs to the Section Physiology and Pathology)

Exploring New Approaches to Disease Treatment with Attenuated Salmonella

edited by

Chamith Hewawaduge

submission deadline 28 Feb 2026 | Viewed by 94 | Submission Open

Keywords: attenuated salmonella; vaccine development; bacterial therapy; cancer immunotherapy; targeted drug delivery

(This special issue belongs to the Section Microbiology)

Germline Susceptibility and Somatic Genetic Alterations in Carcinogenesis

edited by

Jian-Hua Mao

and

Hang Chang

submission deadline 28 Feb 2026 | Viewed by 94 | Submission Open

Keywords: gene mutation; genetic susceptibility; cancer genetics; genome-wide association study; multi-omics; next generation sequencing

(This special issue belongs to the Section Physiology and Pathology)

Osteoarthritis: New Insights into Mechanisms, Diagnosis, Therapy and Management

edited by Tommaso Greco and

Carlo Perisano

submission deadline 1 Mar 2026 | 1 articles | Viewed by 599 | Submission Open

Keywords: osteoarthritis; joint degeneration; artificial intelligence; 3D printing; augmented reality; arthroplasty; joint replacement; disease-modifying therapies

(This special issue belongs to the Section Medical Research)

The Brain-Boosting Power of Exercise: Improving Cerebrovascular and Cognitive Health

edited by

Dean E. Mills

and

Edward Bliss

submission deadline 2 Mar 2026 | Viewed by 117 | Submission Open

Keywords: exercise; training; cerebrovascular; cognition; aerobic; resistance; multimodal

(This special issue belongs to the Section Physiology and Pathology)

Immune Reset and Renal Recovery: Novel Insights into Kidney Inflammation and Repair

edited by Mohanraj Sadasivam

submission deadline 13 Mar 2026 | Viewed by 172 | Submission Open

Keywords: renal immunopathology; immune reset; CAR-T-cell therapy; B-cell depletion; mRNA therapies; autoimmune kidney disease; lupus nephritis; T-cell tolerance; kidney inflammation; renal regeneration

(This special issue belongs to the Section Medical Research)

Advances in 5-Aminolevulinic Acid Applications in Medical and Healthcare

edited by Motowo Nakajima, Walter Stummer and Shun-ichiro Ogura

submission deadline 15 Mar 2026 | 5 articles | Viewed by 10213 | Submission Open

Keywords: 5-aminolevulinic acid (5-ALA); heme; protoporphyrin IX; photodynamic diagnosis; fluorescence guided surgery; photodynamic therapy; cancer metastasis; reactive oxygen species (ROS); oxide radical; heme oxygenase 1 (HO-1); NF-E2-related factor 2 (Nrf2); anti-inflammation; mitochondrial disease; diabetes; infectious disease; malaria; COVID-19

(This special issue belongs to the Section Pharmaceutical Science)

Evolutionary and Conservation Genetics: 3rd Edition

edited by

Daria Sanna

and Ilenia Azzena

submission deadline 15 Mar 2026 | 6 articles | Viewed by 9217 | Submission Open

Keywords: evolutionary genetics; population genetics; conservation genetics; phylogeography; phylogenetics; phylodynamics; molecular taxonomy

(This special issue belongs to the Section Evolutionary Biology)

Organ Predilection of Certain Gastrointestinal Diseases—Pathophysiology, Diagnosis and Management

edited by

Monjur Ahmed

submission deadline 15 Mar 2026 | 1 articles | Viewed by 3123 | Submission Open

Keywords: disease predilection in gastrointestinal tract; esophagus with certain diseases; stomach with certain diseases; duodenum with certain diseases; jejunum with certain diseases; ileum with certain diseases; colorectum with certain diseases

(This special issue belongs to the Section Physiology and Pathology)

2nd Edition—Food Microbiological Contamination

edited by

Sara Primavilla

and

Rossana Roila

submission deadline 16 Mar 2026 | 2 articles | Viewed by 928 | Submission Open

Keywords: food safety; food microbiology; foodborne pathogens; food spoilage; food quality; food contamination; microbiological hazards; natural antimicrobials

(This special issue belongs to the Section Microbiology)

Advances in Substance Abuse and Addiction—2nd Edition

edited by

Cynthia Wei-Sheng Lee

Tsuo-Hung Lan

and Chieh-Liang Huang

submission deadline 18 Mar 2026 | 1 articles | Viewed by 1602 | Submission Open

Keywords: addiction medicine; opioid pharmacology; substance abuse; addictive disorder intervention

(This special issue belongs to the Section Pharmaceutical Science)

Non-Valvular Atrial Fibrillation and Acute Stroke: Prevention and Management

edited by Luca Masotti

submission deadline 18 Mar 2026 | 1 articles | Viewed by 1075 | Submission Open

Keywords: atrial fibrillation; acute ischemic stroke; intracerebral hemorrhage; direct oral anticoagulants; vitamin K antagonists; reversal therapy; tenecteplase; alteplase; intravenous thrombolysis; mechanical thrombectomy; left atrial appendage occlusion; embolic stroke of undetermined source; ECG monitoring

(This special issue belongs to the Section Medical Research)

New Insights Into Artificial Intelligence in Medical Imaging

edited by

Luigi La Via

Antonino Maniaci

Caterina Gagliano

and Salvatore Lavalle

submission deadline 20 Mar 2026 | 3 articles | Viewed by 13433 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; image analysis; precision medicine; image-guided interventions; decision support systems

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition

edited by

Alin Laurentiu Tatu

submission deadline 20 Mar 2026 | 3 articles | Viewed by 10509 | Submission Open

Keywords: Demodex; endosymbionts; cutaneous microbiome; integrative medicine; optical coherence tomography; dermoscopy; confocal microscopy; cutaneous comorbidities keyword; inflammatory diseases; hair; skin cancer; comorbidities; skin surgery

(This special issue belongs to the Section Physiology and Pathology)

Cereal Production Systems: Climate-Fertilizer-Crop Yield Dynamics

edited by

Lukáš Hlisnikovský

and

Veronika Zemanová

submission deadline 20 Mar 2026 | 1 articles | Viewed by 549 | Submission Open

Keywords: cereals; climate; preceding crop; fertilization; grain yield; grain quality; straw yield; soil health; soil chemistry and biology; yield stability; mineral fertilizers; organic manures; tillage

(This special issue belongs to the Section Plant Science)

Towards Resilient Seas: Marine Biodiversity and Ecological Functioning in a Changing Ocean

edited by

Leandro Rodríguez-Viera

and Dorka Cobián-Rojas

submission deadline 20 Mar 2026 | Viewed by 461 | Submission Open

Keywords: marine conservation; ecosystem-based management; biodiversity; climate change adaptation; restoration process; ecological connectivity

(This special issue belongs to the Section Diversity and Ecology)

Bioactive Chemical Constituents of Ornamental Plants

edited by

Linfu Liang

submission deadline 20 Mar 2026 | Viewed by 83 | Submission Open

Keywords: ornamental plants; extraction technologies; structure elucidation; chemical synthesis and biosynthesis; biological investigations

(This special issue belongs to the Section Plant Science)

Green Medicine: Unraveling the Medicinal Effects of Plant Extracts and Functional Foods

edited by

Denis Nchang Che

and

Stefania Lamponi

submission deadline 24 Mar 2026 | 14 articles | Viewed by 42537 | Submission Open

Keywords: plant extracts; phytochemicals; inflammation; obesity; liver disease; oxidative stress; antioxidants; diabetes; skin damage; aging

(This special issue belongs to the Section Pharmaceutical Science)

Novel Therapeutics for Musculoskeletal Disorders

edited by

Dalila Scaturro

and Giulia Letizia Mauro

submission deadline 26 Mar 2026 | 5 articles | Viewed by 4943 | Submission Open

Keywords: osteoarthritis; osteoporosis; bone; arthropathy; joint; pain; lower back pain

(This special issue belongs to the Section Medical Research)

Therapeutic Innovations from Plants and Their Bioactive Extracts

edited by

Rita Kiss

and Annamária Pallag

submission deadline 26 Mar 2026 | 3 articles | Viewed by 2589 | Submission Open

Keywords: herbals; plant extracts; phytochemicals; polyphenols; anthocyanins; natural compounds isolation; herbal extract characterization; bioactive extracts preparation; oxidative stress; apoptosis; inflammation; dermatitis; psoriasis; diabetes mellitus; neurodegenerative disorders; CNS diseases; new target molecules; animal models; clinical studies

(This special issue belongs to the Section Pharmaceutical Science)

Postbiotics—Bioactive Microbial Compounds as Health-Promoting Agents

edited by

Katarzyna Oszajca

and

Janusz Szemraj

submission deadline 27 Mar 2026 | 4 articles | Viewed by 9313 | Submission Open

Keywords: gut microbiota; postbiotics; prebiotics; microbiota-derived metabolites; postbiotic supplementation; postbiotics and health benefits; dysbiosis

(This special issue belongs to the Section Microbiology)

Extremophiles Breakthrough: Hot Topics and Current Issues in Their Isolation, Identification and Biotechnological Applications—2nd Edition

edited by

Martina Aulitto

Giovanni Gallo

and

Emanuela Maresca

submission deadline 27 Mar 2026 | 1 articles | Viewed by 922 | Submission Open

Keywords: astrobiology; biochemistry and molecular biology; biodiversity and ecology; biotechnology; extraterrestrial analogs; extreme environments; extremophiles; genetics; genomics; and proteomics; origin of life; phylogeny and evolution; physiology and metabolism

(This special issue belongs to the Section Microbiology)

From Stem Cells to Embryos, Congenital Anomalies and Epidemiology

edited by

Maria Eleni Manthou

, Soultana Meditskou and

Paschalis Theotokis

submission deadline 30 Mar 2026 | 9 articles | Viewed by 37588 | Submission Open

Keywords: stem cell research; human embryonic development; birth defects epidemiology; birth defects prevalence; maternal and fetal medicine; congenital anomalies prevention; ultrasound evaluation; pre-birth assessment; prenatal screening; healthcare

(This special issue belongs to the Section Epidemiology)

Innovative Perspectives in Physical Therapy and Health

edited by

Carlos Romero-Morales

Gustavo Plaza-Manzano

and

Ricardo Ortega‐Santiago

submission deadline 30 Mar 2026 | 9 articles | Viewed by 33229 | Submission Open

Keywords: physical therapy; health; pain management; musculoskeletal disorders; ultrasonography; rehabilitation; innovative therapies

(This special issue belongs to the Section Medical Research)

Critical Issues in Intensive Care Medicine

edited by

Janos Szederjesi

submission deadline 30 Mar 2026 | 10 articles | Viewed by 21553 | Submission Open

Keywords: critical issues; intensive care; co-morbidities in ICUs; new technology issues in ICUs; hospital-acquired infections; end of life

(This special issue belongs to the Section Medical Research)

Advances in the Treatment of Pulmonary Hypertension and Pulmonary Embolism

edited by

Egidio Imbalzano

and

Marco Vatrano

submission deadline 30 Mar 2026 | 5 articles | Viewed by 16705 | Submission Open

Keywords: pulmonary hypertension; pulmonary embolism; therapy; cardiac imaging; artificial intelligence

(This special issue belongs to the Section Medical Research)

Current Progress in Medical Image Segmentation

edited by

Krishna Chaitanya

submission deadline 30 Mar 2026 | 6 articles | Viewed by 13089 | Submission Open

Keywords: medical image segmentation; deep learning; generative models; algorithm; clinical integration; biological variability; transformer architectures; interactive segmentation; interdisciplinary collaboration

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Physiological Responses of Plants Under Abiotic Stresses

edited by

Dawei Shi

submission deadline 30 Mar 2026 | 6 articles | Viewed by 10814 | Submission Open

Keywords: crops; woody plants; horticultural plants; physiological responses; abiotic stresses; photosynthesis

(This special issue belongs to the Section Plant Science)

From Physiology and Pathology Research to Clinical Insights in Gastrointestinal Disorders

edited by

Doina Georgescu

Felix Bratosin

and Ana Lascu

submission deadline 30 Mar 2026 | 3 articles | Viewed by 10800 | Submission Open

Keywords: cellular signaling; inflammation; oxidative stress; cellular death and proliferation; motility; digestion and absorption; vascular patterns; gut microbiota

(This special issue belongs to the Section Physiology and Pathology)

Eye Diseases: Diagnosis and Treatment, 3rd Edition

edited by

Alba Martín-Gil

and Laura De Diego-García

submission deadline 30 Mar 2026 | 6 articles | Viewed by 10462 | Submission Open

Keywords: ocular treatment; ocular diseases; retina; anterior eye; posterior eye; ocular biomarkers

(This special issue belongs to the Section Medical Research)

Applications of EEG in Neural Rehabilitation: 2nd Edition

edited by

Rubén Pérez-Elvira

Jorge Bosch-Bayard

Alessandra Anzolin

and

Giuseppe Augusto Chiarenza

submission deadline 30 Mar 2026 | 2 articles | Viewed by 9155 | Submission Open

Keywords: neurorehabilitation; neuroplasticity; EEG; ERPs; qEEG; EEG mediated patient-therapist interaction; BCI; exoskeleton; cognitive rehabilitation; brain rewiring

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Chronic Obstructive Pulmonary Disease: Clinical, Epidemiological, and Molecular Bases

edited by

Josef Yayan

submission deadline 30 Mar 2026 | 2 articles | Viewed by 5718 | Submission Open

Keywords: chronic obstructive pulmonary disease; COPD; emphysema; chronic bronchitis

(This special issue belongs to the Section Medical Research)

Gut Microbes Associating with the Host

edited by

Jianmin Chai

and

Kun Li

submission deadline 30 Mar 2026 | 2 articles | Viewed by 5383 | Submission Open

Keywords: gut microbes; microbiome; animals; nutrition

(This special issue belongs to the Section Microbiology)

Encephalitis: From Molecular Pathophysiology to Therapy

edited by Anna Tröscher and Judith Wagner

submission deadline 30 Mar 2026 | 3 articles | Viewed by 4095 | Submission Open

Keywords: infectious encephalitis; autoimmune encephalitis; neuroinflammation; pathophysiology; diagnostics; therapy

(This special issue belongs to the Section Physiology and Pathology)

The Other Pediatric Primary Headaches: 2nd Edition

edited by

Vincenzo Raieli

Vittorio Sciruicchio

and Giuseppe Santangelo

submission deadline 30 Mar 2026 | 2 articles | Viewed by 3912 | Submission Open

Keywords: pediatric TACs; primary pediatric headaches; pediatric tension headaches; preventive treatment; acute treatment; clinical features; children; pediatric headaches in IV 3ICHD

(This special issue belongs to the Section Medical Research)

Advances and Applications of Neuroimaging in Brain Disorder

edited by Julio Plata-Bello

submission deadline 30 Mar 2026 | 1 articles | Viewed by 3777 | Submission Open

Keywords: neuroimaging; magnetic resonance imaging; positron emission tomography; near infrared spectroscopy; brain; dementia; schizophrenia; depression; brain tumors; multiple sclerosis; autism

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Innovations, Utilization, and Safety of Psychiatric Drugs: Current Trends and Future Directions

edited by

Josipa Bukić

submission deadline 30 Mar 2026 | 1 articles | Viewed by 3670 | Submission Open

Keywords: psychiatric diseases; psychiatric medicine; psychiatric pharmacotherapy; psychiatric drugs

(This special issue belongs to the Section Pharmaceutical Science)

Precision Medicine in Cardiovascular Diseases

edited by Brian Xiangzhi Wang

submission deadline 30 Mar 2026 | 2 articles | Viewed by 3588 | Submission Open

Keywords: genomic; cardiovascular disease; congenital; multi-omics studies; precision medicine; personalized medicine; biomarker

(This special issue belongs to the Section Genetics and Genomics)

Microvascular and Macrovascular Response in Healthy and Critically Ill

edited by Andrius Pranskunas and

Marius Brazaitis

submission deadline 30 Mar 2026 | 3 articles | Viewed by 3160 | Submission Open

Keywords: microcirculation; glycocalyx; peripheral perfusion; systemic hemodynamic; body temperature; dynamic maneuvers; remote ischemic conditioning; exercise; adaptation

(This special issue belongs to the Section Physiology and Pathology)

Effects of Exercise Training on Muscle Function—2nd Edition

edited by

Marco Duca

and

Athos Trecroci

submission deadline 30 Mar 2026 | 2 articles | Viewed by 1971 | Submission Open

Keywords: exercise; training; muscle function; resistance training; HIIT

(This special issue belongs to the Section Physiology and Pathology)

Biological Insights into Drug Safety for Vulnerable Populations

edited by

Dulce Estêvão

and

Margarida Espírito-Santo

submission deadline 30 Mar 2026 | Viewed by 374 | Submission Open

Keywords: drug safety; vulnerable populations; pharmacotherapy; drug metabolism and efficacy; pediatric medication safety; drug pharmacokinetics and pharmacodynamics

(This special issue belongs to the Section Pharmaceutical Science)

Recent Advances in Non-Invasive Diagnosis Based on Volatile Metabolites

edited by Kiran Sankar Maiti

submission deadline 30 Mar 2026 | Viewed by 330 | Submission Open

Keywords: volatile metabolites; breath analysis; headspace analysis; biofluids; non-invasive; diagnosis

(This special issue belongs to the Section Medical Research)

Novel Insights into Biomarkers and Molecular Mechanisms in Heart Failure

edited by

Chun-Chao Chen

Wen-Rui Hao

and

Ju-Chi Liu

submission deadline 30 Mar 2026 | Viewed by 110 | Submission Open

Keywords: heart failure; biomarkers; molecular mechanisms

(This special issue belongs to the Section Physiology and Pathology)

Advances in the Structure and Function of Microbial Communities

edited by

Qing Hu

and

Xuliang Zhuang

submission deadline 31 Mar 2026 | 4 articles | Viewed by 9858 | Submission Open

Keywords: microbial communities; ecosystem dynamics; community structure; functional diversity; interactions; ecological processes; sustainability

(This special issue belongs to the Section Microbiology)

New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease: 2nd Edition

edited by

Laura Patton

and

Guido Gabriele

submission deadline 31 Mar 2026 | 1 articles | Viewed by 6264 | Submission Open

Keywords: adipose tissue; lipedema; lymphedema; obesity; matrix; vascular and lymphatic disorder; connective tissue diseases; dysbiosis; inflammation; pain

(This special issue belongs to the Section Medical Research)

Vision Science and Optometry: 2nd Edition

edited by

Ana Sanchez-Cano

and

Elvira Orduna-Hospital

submission deadline 31 Mar 2026 | 5 articles | Viewed by 5555 | Submission Open

Keywords: clinical optometry; eye movements and binocular vision; aberrometry; accommodation; color vision; anterior and posterior pole; circadian light

(This special issue belongs to the Section Medical Research)

Advanced Machine Learning for Disease Prediction and Prevention

edited by

Jawad Khan

and

Dildar Hussain

submission deadline 31 Mar 2026 | 3 articles | Viewed by 4729 | Submission Open

Keywords: advanced machine learning; disease prediction; disease prevention; biomedical data integration; multimodal data; explainable AI (XAI); AI Interpretability; algorithmic fairness; bias mitigation; predictive modeling; healthcare analytics; risk stratification; early disease detection; clinical decision support; computational health; public health informatics; AI ethics in healthcare; medical AI validation; health data science; personalized medicine

(This special issue belongs to the Section Medical Research)

Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges: 2nd Edition

edited by

Daniela Maria Tanase

Mariana Floria

and

Ionela Lacramioara Serban

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4328 | Submission Open

Keywords: hyperlipidemia; neuropathy; nephropathy; retinopathy; psychological effects; epigenetic imprinting; molecular profiling; glucose control; vascular damage and regeneration; diabetes complications

(This special issue belongs to the Section Physiology and Pathology)

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