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Life
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Minimally Invasive and Transcatheter Interventions in Valvular Heart Disease
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Minimally Invasive and Transcatheter Interventions in Valvular Heart Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 18 July 2026 | Viewed by 1190

Special Issue Editor

Dr. Adam R. Kowalówka

E-Mail Website
Guest Editor
Department of Cardiac Surgery, Medical University of Silesia Katowice, Katowice, Poland
Interests: cardiac surgery; cardiovascular interventions

Special Issue Information

Dear Colleagues,

Valvular heart disease remains a major contributor to cardiovascular morbidity and mortality globally, with treatment modalities evolving rapidly to minimize surgical traumas and enhance long-term outcomes. This Special Issue focuses on Minimally Invasive and Transcatheter Interventions in Valvular Heart Disease, emphasizing state-of-the-art techniques, outcome optimization, and patient-centered therapeutic strategies. By integrating surgical precision with interventional innovation, this Special Issue explores contemporary advances transforming valve repair and replacement paradigms.

This platform invites clinicians, researchers, and allied professionals to disseminate high-quality, evidence-based work addressing the clinical efficacy, safety, and durability of minimally invasive and transcatheter valve procedures. Topics of special interest include surgical and transcatheter aortic valve replacement, mitral and tricuspid valve interventions, hybrid approaches, perioperative imaging and navigation technology, and long-term outcome analyses. We welcome original research, systematic reviews, and clinical case studies highlighting procedural innovation, device technology, and comparative effectiveness across diverse patient groups.

This Special Issue seeks to bridge translational gaps between clinical trials and real-world practice, fostering multidisciplinary collaboration to refine patient selection and risk stratification in valvular therapy. Particular emphasis will be placed on clinical outcomes in complex and high-risk populations, including those with bicuspid valve anatomy, prior cardiac surgery, or multiple comorbidities. Through the collective contribution of global expertise, this Special Issue aims to advance best practices and promote continuous evolution in the minimally invasive and transcatheter management of valvular heart disease.

Dr. Adam R. Kowalówka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transcatheter aortic valve replacement
  • minimally invasive cardiac surgery
  • aortic valve interventions
  • structural heart disease
  • valve repair outcomes

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Published Papers (2 papers)

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Research

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14 pages, 806 KB  
Article
Screening and Qualification for Transcatheter Tricuspid Valve Interventions—Preliminary Findings from the CAPTURE Pilot Study
by Adam Rdzanek, Adam Piasecki, Ewa Pędzich, Ewa Ostrowska, Paweł Pawłowicz, Ewa Borowiak, Agnieszka Kapłon-Cieślicka, Janusz Kochman, Mariusz Tomaniak, Piotr Scisło and Francesco Maisano
Life 2026, 16(4), 602; https://doi.org/10.3390/life16040602 - 4 Apr 2026
Viewed by 324
Abstract
Background: Transcatheter tricuspid edge-to-edge repair (T-TEER) is the most widely used treatment option for patients with tricuspid regurgitation (TR). In real-world practice, a substantial proportion of referred patients are not eligible for T-TEER or do not achieve an adequate early TR reduction and [...] Read more.
Background: Transcatheter tricuspid edge-to-edge repair (T-TEER) is the most widely used treatment option for patients with tricuspid regurgitation (TR). In real-world practice, a substantial proportion of referred patients are not eligible for T-TEER or do not achieve an adequate early TR reduction and may therefore require alternative transcatheter tricuspid valve interventions (TTVI)—orthotopic or heterotopic tricuspid valve implantation. The aim of the study was to characterize patients with severe TR referred for transcatheter treatment, and identify patients in whom alternative TTVI strategies may be required. Methods: The CAPTURE Study (NCT 06838611) enrolls consecutive patients referred for TR treatment. All patients undergo clinical and echocardiographic assessment to determine eligibility for T-TEER. Candidates for alternative TTVI strategies were defined as patients disqualified from T-TEER due to anatomical ineligibility or those with unsuccessful T-TEER, defined as next-day TTE showing TR more than moderate. This pilot analysis includes patients enrolled from November 2023 to December 2024. Results: 147 patients were enrolled, 77 (52.4%) patients were qualified for T-TEER and the procedure was performed in 71 (48.3%) patients, with successful TR reduction in 55 cases (77.5% of treated patients); a subset of 34 patients (23.1%) was identified as potential candidates for alternative TTVI strategies. These patients exhibited more advanced TR (torrential TR 76.5% vs. 18.2%; p < 0.001) and right heart failure symptoms (ascites 44.1% vs. 12.7%; p < 0.001). Additionally, they had significantly higher bilirubin concentration (1.09 [1.20] mg/dL vs. 0.61 [0.42] mg/dL; p = 0.003), lower hemoglobin level (11.8 [1.7] g/dL vs. 12.3 [1.7] g/dL; p = 0.017) and platelet count (161.0 [51.0] × 109/L vs. 183.0 [79.0] × 109/L; p = 0.015), suggesting an increased bleeding risk. Conclusions: In this preliminary single-center real-world cohort, approximately half of the patients with severe TR were eligible for T-TEER, whereas more than 20% emerged as potential candidates for alternative TTVI strategies. This subgroup was characterized by more advanced right-sided remodeling and laboratory features suggestive of hepatic dysfunction and increased bleeding risk, which may have important implications for Heart Team decision-making and procedural planning. Full article
(This article belongs to the Special Issue Minimally Invasive and Transcatheter Interventions in Valvular Heart Disease)
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Other

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12 pages, 3280 KB  
Case Report
Percutaneous Closure of a Large-Bore Carotid Arteriotomy Using a Collagen-Based Vascular Plug
by Radoslaw Parma, Radoslaw Gocol, Joanna Nawara-Skipirzepa, Ryszard Bachowski, Wojciech Wojakowski and Damian Hudziak
Life 2026, 16(2), 292; https://doi.org/10.3390/life16020292 - 9 Feb 2026
Viewed by 522
Abstract
Background: Inadvertent arterial cannulation during central venous catheter placement is a recognized complication with potentially serious consequences, particularly when involving large-caliber catheters. While management strategies have evolved from mandatory surgical repair to various percutaneous approaches, limited data exist regarding collagen-based vascular closure [...] Read more.
Background: Inadvertent arterial cannulation during central venous catheter placement is a recognized complication with potentially serious consequences, particularly when involving large-caliber catheters. While management strategies have evolved from mandatory surgical repair to various percutaneous approaches, limited data exist regarding collagen-based vascular closure devices for large-bore carotid arteriotomies. Case Presentation: We report the case of a 59-year-old male patient with acute Stanford Type A aortic dissection who underwent emergency surgical repair of the ascending aorta. During central venous cannulation, a five-lumen Certofix Quinto catheter (12-French outer diameter) was inadvertently inserted into the left common carotid artery. Given the complexity of concurrent cardiac surgery and the large-bore nature of the arteriotomy, percutaneous closure with an 18-French MANTA vascular closure device was successfully performed following completion of the aortic repair. The procedure achieved immediate hemostasis without complications. Outcomes: The patient remained neurologically intact throughout a 12-month follow-up period. Serial duplex ultrasonography and computed tomography angiography confirmed carotid artery patency without evidence of stenosis, dissection, pseudoaneurysm formation, or thromboembolic complications. Conclusions: This case demonstrates the technical feasibility of using a collagen-based vascular closure device for percutaneous management of a large-bore carotid arteriotomy in the acute surgical setting. While the outcome was favorable in this patient, this approach represents an off-label application that requires further validation and should be reserved for carefully selected cases in experienced centers where the benefits of percutaneous closure are judged to outweigh the uncertainties of supra-aortic device deployment. Full article
(This article belongs to the Special Issue Minimally Invasive and Transcatheter Interventions in Valvular Heart Disease)
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