Novel Insights into Environmental Agents' Toxicity and Therapeutic Strategies
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 169
Special Issue Editors
Interests: neurotoxicology; endocrine disruption; environmental pollutants; drugs safety evaluation
Special Issues, Collections and Topics in MDPI journals
Interests: neurotoxicology; endocrine disruption; environmental pollutants; drugs safety evaluation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are living in an era defined by unprecedented environmental change. Human populations are continuously exposed to a complex and expanding mixture of anthropogenic agents, including industrial chemicals, heavy metals, air particulate matter, microplastics, and endocrine disruptors. While their individual toxicological profiles are partially understood, significant gaps remain regarding their long-term effects, combined exposure (the "mixture effect"), underlying molecular mechanisms, and the delayed onset of chronic diseases.
This Special Issue aims to bridge these critical gaps by curating cutting-edge research that moves beyond descriptive toxicology. We seek to foster a comprehensive dialogue on the pathogenic pathways—from genomic instability and epigenetic alterations to immune dysregulation and organ-specific damage—triggered by environmental insults. Concurrently, a core pillar of this Issue is to explore pioneering interventional and therapeutic strategies. This includes pharmacological approaches, lifestyle and dietary interventions, the use of bioactive natural compounds, advanced detoxification methods, and innovative biomaterials for mitigation.
Scope and Call for Contributions:
We invite original research articles, reviews, and perspectives that provide novel insights into the following:
- Advanced mechanistic studies of toxicity using in silico, in vitro, and in vivo models.
- Biomarker discovery for early detection of exposure and effect.
- Studies on transgenerational effects and the role of the exposome in disease etiology.
- Development and evaluation of therapeutic, protective, or remediation strategies against environmental toxicity.
- Systems biology approaches integrating multi-omics data to decipher complex toxicity networks.
By bringing together diverse expertise, this Special Issue will serve as a foundational resource, highlighting emerging threats and translating mechanistic understanding into potential solutions. We welcome submissions that push the boundaries of environmental health science toward a more predictive, preventive, and therapeutic paradigm.
As Guest Editors, we would be very pleased if you joined us in contributing to a critical scholarly collection designed to impact both scientific understanding and future public health policies.
Prof. Dr. Javier del Pino
Prof. Dr. Paula Moyano
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- environmental toxicology
- molecular mechanisms of toxicity
- therapeutic interventions
- exposome
- endocrine disruptors
- biomonitoring
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