New Insights into Cell Death Mechanisms and Multi-Omics in Cancer
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 89
Editor
Interests: programmed cell death; tumor microenvironment; chronic inflammation; hematology; experimental hematology; hematologic diseases; hematologic neoplasms
Special Issue Information
Dear Colleagues,
Aims and Scope
Cancer remains one of the leading causes of morbidity and mortality worldwide, and a deeper understanding of the molecular mechanisms governing cell death is central to the development of more effective therapeutic strategies. This Special Issue aims to bring together cutting-edge research that explores the diverse and interconnected pathways of cell death—including apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy-dependent cell death, and immunogenic cell death—in the context of human malignancies.
A particular focus will be placed on the integration of multi-omics approaches—encompassing genomics, transcriptomics, proteomics, metabolomics, and epigenomics—to unravel the complex regulatory networks that determine cancer cell fate. By leveraging large-scale omics datasets, single-cell analyses, and real-world data, this collection seeks to identify novel biomarkers, therapeutic targets, and resistance mechanisms relevant to oncology practice.
Topics of Interest
Submissions are welcome on the following topics, including but not limited to
- Molecular mechanisms of regulated cell death in hematologic and solid malignancies
- Ferroptosis, pyroptosis, necroptosis, and cuproptosis in cancer biology and therapy
- Multi-omics integration for cancer biomarker discovery and patient stratification
- Single-cell transcriptomics and spatial omics in tumor microenvironment research
- Immunogenic cell death and its implications for cancer immunotherapy
- Autophagy and its dual roles in tumor suppression and progression
- Epigenetic regulation of cell death pathways in cancer
- Liquid biopsy and ctDNA/cfRNA profiling as multi-omics tools in cancer monitoring
- Drug resistance mechanisms related to cell death pathway dysregulation
- Translational and clinical studies connecting cell death biology to treatment outcomes
Dr. Yu-Guang Chen
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell death
- apoptosis
- ferroptosis
- pyroptosis
- necroptosis
- cuproptosis
- autophagy
- multi-omics
- genomics
- transcriptomics
- proteomics
- cancer
- tumor microenvironment
- biomarkers
- immunotherapy
- liquid biopsy
- single-cell sequencing
- drug resistance
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