Endometrial Stem/Progenitor Cell Biology: Prospects and Challenges

Dear Colleagues,

The human endometrium is one of the most regenerative tissues in the body, undergoing unique cycles of menstrual shedding and regeneration over 400 times during reproductive life. Each month, approximately one centimetre of mucosal tissue, comprising glands and stroma, is generated. This phenomenon is not shared by any typical model organisms which undergo sexual reproduction and is likely mediated by endometrial stem/progenitor cells. Several types of stem/progenitor cells have been identified: endometrial mesenchymal stem cells, endometrial epithelial progenitor cells and side population cells comprising a heterogeneous population, predominantly endothelial cells.

This Special Issue aims to highlight the challenges in endometrial stem/progenitor cell research, the importance of characterising these rare populations and the issues to consider in developing them for stem cell therapies. The application of endometrial stem/progenitor cells as a cell-based therapy for treating disorders will be welcomed.

Areas to be covered in this Special Issue may include but are not limited to: recent evidence of cell-based therapies utilising endometrial derived mesenchymal stem cells, endometrial epithelial progenitors, topics including endometrial clonal evolution, mutation burden, 3D histoarchitecture and endometrial epithelial organoids and next generation sequencing at the single cell level, which may have important relevance to endometrial stem/ progenitor cell biology and application in personalised medicine.

We expect that this Special Issue will provide novel information on the abovementioned topics and will be of interest to scientists and clinicians already working or seeking to undertake research at the intersection of endometrial stem cell biology and cell-based therapies. Therefore, contributions by experts in the field, in the form of original research papers and reviews are most welcome.

Prof. Caroline E. Gargett
Prof. Dharani Hapangama
Guest Editors

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