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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Frontiers in Myocardial Infarction: From Acute Revascularization to Long-Term Secondary Prevention

edited by

Nikolaos Stalikas

submission deadline 20 Feb 2027 | 1 articles | Viewed by 826 | Submission Open

Keywords: complete revascularization; myocardial infarction; vulnerable plaque; imaging guided PCI; biomarkers; secondary prevention; microvascular disease; endothelial dysfunction

(This special issue belongs to the Section Cardiology)

Robotic-Assisted Hepato-Pancreato-Biliary (HPB) Surgery: Advances and Clinical Perspectives

edited by

Michele Tedeschi

and Riccardo Memeo

submission deadline 20 Feb 2027 | 1 articles | Viewed by 782 | Submission Open

Keywords: liver surgery; pancreatic surgery; HPB surgery; robotic surgery; robotic systems; advances in HPB surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Orthopedic Oncology Updates and Controversial Issues

edited by Yehuda Kollender and Ron Batash

submission deadline 20 Feb 2027 | Viewed by 778 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; oligometastatic; atypical behavior tumor; cryosurgery; rare diseases; surgery; radiation therapy; immunotherapy; chemotherapy

(This special issue belongs to the Section Orthopedics)

Advances in the Field of Cariology

edited by

Aline Castilho

and

Frank Lippert

submission deadline 20 Feb 2027 | 1 articles | Viewed by 740 | Submission Open

Keywords: dental caries; caries diagnosis; caries risk assessment; minimally invasive dentistry; preventive strategies

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pediatric Surgery—Current Hurdles and Future Perspectives—2nd Edition

edited by

Osnat Zmora

submission deadline 20 Feb 2027 | 1 articles | Viewed by 719 | Submission Open

Keywords: congenital anomalies; esophageal atresia; anorectal malformations; pediatric trauma; necrotizing enterocolitis; pediatric oncology; biliary atresia

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Research and Management of Infectious Diseases

edited by

Vasilis Petrakis

submission deadline 20 Feb 2027 | 1 articles | Viewed by 568 | Submission Open

Keywords: antimicrobial resistance (AMR); novel antibiotics; multidrug-resistant (MDR) pathogens; drug discovery and development; bacteriophage therapy; antimicrobial peptides; ESKAPE pathogens; antimicrobial stewardship

(This special issue belongs to the Section Infectious Diseases)

New Concepts in the Diagnosis and Treatment of Orthopedic Diseases in Children—2nd Edition

edited by

Sergio De Salvatore

and

Laura Ruzzini

submission deadline 20 Feb 2027 | Viewed by 441 | Submission Open

Keywords: pediatric orthopedics; flatfoot; genu valgum; genu varum; hip dysplasia; clubfoot; early onset scoliosis; Scheuermann disease; perthes; epiphysiolysis; scoliosis; pediatric trauma

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Advances in Orthopedic Infections: 2nd Edition

edited by

Hyonmin Choe

submission deadline 20 Feb 2027 | Viewed by 391 | Submission Open

Keywords: orthopedic surgery; orthopedic infections; periprosthetic joint infection; surgical site infection; infection management

(This special issue belongs to the Section Orthopedics)

Advances in Pulmonary Embolism Therapeutics

edited by

Jeisson Osorio

submission deadline 20 Feb 2027 | Viewed by 370 | Submission Open

Keywords: acute pulmonary embolism; chronic pulmonary embolism; chronic thromboembolic disease; chronic thromboem-bolic pulmonary hypertension; catheter-directed therapy; pulmonary endarterectomy; balloon pulmonary angio-plasty

(This special issue belongs to the Section Vascular Medicine)

Current and Emerging Management Strategies in Gynecologic Oncology

edited by Grzegorz Szewczyk

submission deadline 20 Feb 2027 | Viewed by 347 | Submission Open

Keywords: gynecologic oncology; surgical approach; molecular diagnostics; novel therapies; rare gynecological cancers; risk factors

(This special issue belongs to the Section Obstetrics & Gynecology)

Hematoinflammatory Diseases: Bridging Autoimmunity and Autoinflammation

edited by Andrés González García and

José Hernández-Rodríguez

submission deadline 20 Feb 2027 | Viewed by 335 | Submission Open

Keywords: hematoinflammatory diseases; clonal hematopoiesis; vexas syndrome; castleman disease; Igg4-related disease; cytokine storm; autoinflammatory syndromes; immunopathogenesis; targeted therapies; biomarkers

(This special issue belongs to the Section Immunology & Rheumatology)

Towards a Better Understanding of Neuroinflammation in Mental Health

edited by Jesus Cobo

submission deadline 20 Feb 2027 | Viewed by 307 | Submission Open

Keywords: neuroinflammation; biomarkers; peripheral biomarkers; outcomes; bipolar disorders; major depression; mental health; schizophrenia; blood-based inflammatory index; lymphocyte subpopulation

(This special issue belongs to the Section Mental Health)

Current Practices and Future Challenges in Organ Transplantation

edited by

Al-Faraaz Kassam

and Mackenzie Morris

submission deadline 20 Feb 2027 | Viewed by 300 | Submission Open

Keywords: liver transplantation; kidney transplantation; pancreas transplantation; xenotransplantation; immunosuppression; robotic surgery; disparities; machine perfusion; organ preservation; organ allocation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Regenerative and Biologic Therapies for Musculoskeletal Disorders

edited by

Diego Delgado

and

Mikel Sánchez

submission deadline 20 Feb 2027 | Viewed by 218 | Submission Open

Keywords: regenerative medicine; musculoskeletal disorders; cell-based therapy; platelet-rich plasma; extracellular vesicles; tissue engineering; osteoarthritis; tendon; cartilage; bone; skeletal muscle; translational research; preclinical research; clinical research

(This special issue belongs to the Section Clinical Rehabilitation)

Alcohol Use Disorder: New Clinical Insights and Management Strategies

edited by Daniel König

submission deadline 20 Feb 2027 | Viewed by 153 | Submission Open

Keywords: alcohol use disorder; emerging treatments; comorbidities; outcomes; epidemiology; dual-diagnosis; interventions

(This special issue belongs to the Section Mental Health)

New Perspectives on Musculoskeletal Injuries and Disorders: Advancing Diagnosis, Treatment, and Recovery

edited by Shinnosuke Hada

submission deadline 20 Feb 2027 | Viewed by 131 | Submission Open

Keywords: musculoskeletal injuries; musculoskeletal disorders; clinical diagnosis; treatment strategies; clinical outcomes; orthobiologics; platelet-rich plasma; sports medicine; osteoarthritis; ultrasound-guided intervention; rehabilitation; return to activity; functional recovery

(This special issue belongs to the Section Orthopedics)

Optimizing Cardiovascular Intervention: From Technology Innovation to Clinical Practice

edited by

Tomasz Tokarek

submission deadline 20 Feb 2027 | Viewed by 44 | Submission Open

Keywords: cardiovascular intervention; interventional cardiology; coronary artery disease; structural heart disease; PCI

(This special issue belongs to the Section Cardiovascular Medicine)

Oral Surgery: Recent Advances and Future Perspectives

edited by

Carlo Barausse

and

Gerardo Pellegrino

submission deadline 22 Feb 2027 | 3 articles | Viewed by 8928 | Submission Open

Keywords: oral surgery; implant dentistry; atrophic jaws; bone regeneration; digital dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances and New Perspectives in the Diagnosis and Treatment of Schizophrenia

edited by Pierre S. Chue and Oloruntoba J. Oluboka

submission deadline 22 Feb 2027 | 2 articles | Viewed by 1377 | Submission Open

Keywords: psychopharmacology; schizophrenia; long-acting injectable therapy; recovery; team approach to care; integrated care; clozapine; habilitation; rehabilitation; early intervention

(This special issue belongs to the Section Mental Health)

Clinical Aspects of Cardiac Arrhythmias and Arrhythmogenic Disorders

edited by

Piotr Bienias

and Jakub Baran

submission deadline 25 Feb 2027 | 8 articles | Viewed by 9777 | Submission Open

Keywords: non-invasive arrhythmia assessment; electrocardiography; invasive arrhythmia assessment; invasive electrophysiology; catheter ablation; implantable devices; rare diseases and arrhythmias; arrhythmia risk stratification; genetics aspects of arrhythmogenesis; channelopathy

(This special issue belongs to the Section Cardiology)

Current Advances and Future Perspectives of Ischemic Stroke

edited by

Marzia Baldereschi

submission deadline 25 Feb 2027 | 4 articles | Viewed by 7407 | Submission Open

Keywords: acute ischemic stroke care; neuroimaging in ischemic stroke; alteplase and tenecteplase; endovascular treatments; recanalization and reperfusion; prognostication in stroke patients; blood–brain barrier in ischemic stroke; bi-omarkers in ischemic stroke; omics in stroke

(This special issue belongs to the Section Clinical Neurology)

Advances and Updates in Migraine

edited by

Hartmut Göbel

and Carl H. Göbel

submission deadline 25 Feb 2027 | 6 articles | Viewed by 5668 | Submission Open

Keywords: migraine; chronic migraine; headache disorders; CGRP antibodies; gepants; ditans; triptans; precision medicine; neuromodulation; comorbidities; disability burden; pediatric migraine; ICHD-3 classification; neurotransmitters; preventive therapy; translational headache research

(This special issue belongs to the Section Clinical Neurology)

New Insights in Cognitive Aging and Mild Cognitive Impairment

edited by

Irene Fernández

and

Laura Galiana

submission deadline 25 Feb 2027 | 5 articles | Viewed by 5307 | Submission Open

Keywords: cognitive aging; mild cognitive impairment; normative aging; neuropsychological assessment; diagnosis; gerontology; prevention; intervention; multidisciplinary approach; measurement

(This special issue belongs to the Section Geriatric Medicine)

Headache Disorders: New Advances in Management and Treatment Strategies: 2nd Edition

edited by

Andreas A. Argyriou

Emmanouil V. Dermitzakis

and

Vikelis Michail

submission deadline 25 Feb 2027 | 3 articles | Viewed by 5283 | Submission Open

Keywords: headache; migraine; cluster headache; tension-type headache; post-traumatic headache; calcitonin gene-related peptide; monoclonal antibodies; preventive therapy; acute treatment; pathophysiology; neuromodulation; pain management; drug development; gepants; ditan

(This special issue belongs to the Section Clinical Neurology)

Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition

edited by

Eleonora M.C. Trecca

and

Andrea Albera

submission deadline 25 Feb 2027 | 5 articles | Viewed by 5136 | Submission Open

Keywords: middle ear; inner ear; endoscopic ear surgery; cholesteatoma; Menière’s disease; hearing loss; robotic surgery; oto-sclerosis

(This special issue belongs to the Section Otolaryngology)

Innovative Aspects in Dental Implantology and Related Clinical Research (Second Edition)

edited by

Carlo Barausse

and

Gerardo Pellegrino

submission deadline 25 Feb 2027 | 3 articles | Viewed by 4871 | Submission Open

Keywords: dental implants; implantology; bone regeneration; implant-supported prosthesis; zygomatic implants; reconstructive surgery; pre-implant surgery; short implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advanced Hepato-Pancreato-Biliary Surgery: Clinical Innovations and Improved Outcomes

edited by Ahmad Mahamid and Riad Haddad

submission deadline 25 Feb 2027 | 3 articles | Viewed by 4471 | Submission Open

Keywords: liver surgery; pancreas surgery; biliary surgery; robotic HPB surgery; single incision surgery; prognostic biomarkers; perioperative clinical care; postoperative complications

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Cardiovascular Rehabilitation: The Central Role of Exercise in Prevention and Care

edited by Massimo Pistono

submission deadline 25 Feb 2027 | 4 articles | Viewed by 4008 | Submission Open

Keywords: cardiac rehabilitation; secondary prevention; physical exercise; cardiovascular health; aerobic exercise; cardio-oncology rehabilitation

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Updates in Cardiovascular Computed Tomography (CT)

edited by

Antonella Meloni

submission deadline 25 Feb 2027 | 2 articles | Viewed by 3948 | Submission Open

Keywords: cardiovascular CT; coronary CTA; plaque imaging; artificial intelligence; low-dose imaging; structural heart disease; cardiac imaging; high-risk plaque; atherosclerosis; coronary artery disease; valve calcification; thrombus detection

(This special issue belongs to the Section Cardiovascular Medicine)

Hospital-Acquired Infections: Evolving Threats and Epidemiological Insights

edited by

Amir Nutman

submission deadline 25 Feb 2027 | 4 articles | Viewed by 3691 | Submission Open

Keywords: hospital-acquired infections; healthcare-associated infections; antimicrobial resistance; multidrug-resistant organisms (MDRO); infection prevention and control; outbreak investigation; patient safety; healthcare epidemiology

(This special issue belongs to the Section Infectious Diseases)

Geriatric Cardiology: Clinical Advances and Comprehensive Management

edited by

Iris Parrini

submission deadline 25 Feb 2027 | 2 articles | Viewed by 2958 | Submission Open

Keywords: geriatric assessment; management of cardiovascular disease; cardiovascular health; geriatric cardiology; frailty evaluation and management

(This special issue belongs to the Section Geriatric Medicine)

Endoscopic Therapy in Gastroesophageal Reflux Disease (GERD): Current Evidence, Techniques, and Future Perspectives

edited by Pier Alberto Testoni

submission deadline 25 Feb 2027 | 1 articles | Viewed by 2818 | Submission Open

Keywords: gastroenterology; gastroesophageal reflux disease; GERD; esophageal diseases; endoscopic therapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Clinical Advances in Cardiac Rehabilitation: 2nd Edition

edited by

Tomasz Rechciński

submission deadline 25 Feb 2027 | 2 articles | Viewed by 2412 | Submission Open

Keywords: cardiac rehabilitation; kinesiotherapy; psychological support; lifestyle modifications; myocardial infarction; heart failure

(This special issue belongs to the Section Cardiology)

Advancing Neonatal Seizures and Epilepsy: New Perspectives and Interventions

edited by

Elena Pavlidis

and Gaetano Cantalupo

submission deadline 25 Feb 2027 | 1 articles | Viewed by 2187 | Submission Open

Keywords: neonatal seizures; neonatal epilepsy; neonatal EEG; automated EEG analysis; neonatal brain monitoring; genetic; precision medicine; genetic epilepsies; genome; exome

(This special issue belongs to the Section Clinical Pediatrics)

Cardiometabolic Disease and Atherosclerosis: Epidemiology, Prevention, Diagnosis, and Clinical Treatment—2nd Edition

edited by

Evangelos Oikonomou

and Konstantinos Mourouzis

submission deadline 25 Feb 2027 | 2 articles | Viewed by 1988 | Submission Open

Keywords: atherosclerosis; obesity; cardiometabolic disease; prevention; diabetes mellitus; endothelium; arteriosclerosis; coronary artery disease

(This special issue belongs to the Section Cardiology)

Optimizing Radiotherapy in Clinical Practice: Innovation and Outcomes

edited by

Sarah Han-Oh

Senthamizhchelvan Srinivasan

and Joseph Moore

submission deadline 25 Feb 2027 | 2 articles | Viewed by 1611 | Submission Open

Keywords: AI-assisted automated contouring and planning; AI-assisted quality assurance; AI-assisted safety and quality improvement; radiotherapy automation; radiomics; radiotherapy error detection; personalized radiopharmaceutical therapy; theranostics; online adaptive radiotherapy; real-time treatment adaptation; image-guided radiotherapy (IGRT); AI-assisted online adaptation; personalized radiotherapy; cone-beam CT adaptation

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Updates and Current Challenges in Obstetrical Anesthesia

edited by Michael Froelich

submission deadline 25 Feb 2027 | 1 articles | Viewed by 1532 | Submission Open

Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care

(This special issue belongs to the Section Obstetrics & Gynecology)

Emerging Trends and Therapeutic Innovations in Corneal and Ocular Surface Disorders

edited by

Zala Lužnik Marzidovšek

and Špela Štunf Pukl

submission deadline 25 Feb 2027 | 2 articles | Viewed by 1372 | Submission Open

Keywords: corneal diseases; ocular surface disorders; regenerative medicine; stem cell therapy; gene therapy; nanomedicine and targeted drug delivery

(This special issue belongs to the Section Ophthalmology)

Advances in Clinical Practice and Personalized Approaches in Cardiovascular Disease—2nd Edition

edited by Joseph B. Selvanayagam and

Sivabaskari Pasupathy

submission deadline 25 Feb 2027 | 2 articles | Viewed by 1232 | Submission Open

Keywords: personalized medicine; cardiovascular innovations; cardiac imaging; risk assessment; multimodal imaging; therapeutic strategies; data-driven decision making; clinical outcomes; translational research

(This special issue belongs to the Section Cardiovascular Medicine)

Pediatric Sleep Health: From Pathophysiology to Quality of Life

edited by

Melanie Koelbel

and

Fenella Jane Kirkham

submission deadline 25 Feb 2027 | 1 articles | Viewed by 913 | Submission Open

Keywords: pediatric sleep; sleep disorders; child development; cognition; quality of life; neurodevelopment; pathophysiology; sleep health interventions; academic; sleep-disordered breathing; MRI; neuroscience

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Advancements in Laparoscopic Surgery for Gastrointestinal Diseases

edited by

Nikolaos Pararas

submission deadline 25 Feb 2027 | 1 articles | Viewed by 678 | Submission Open

Keywords: laparoscopic surgery; minimally invasive surgery; gastrointestinal diseases; colorectal cancer; gastric cancer; robotic surgery; fluorescence imaging; endoscopic-laparoscopic hybrid surgery; surgical oncology; future perspectives

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Interplay of Trauma Symptoms and Cognitive Functioning: Clinical Implications

edited by

Jonathan Guez

and

Rotem Saar

submission deadline 25 Feb 2027 | Viewed by 393 | Submission Open

Keywords: trauma; stress; cognitive dysfunction; clinical syndromes; clinical implications

(This special issue belongs to the Section Mental Health)

Surgical Innovations in Pediatric Orthopedics

edited by

Hoon Park

submission deadline 25 Feb 2027 | Viewed by 383 | Submission Open

Keywords: pediatric orthopedics; surgical innovation; growth modulation; absorbable implant; 3D printing

(This special issue belongs to the Section Orthopedics)

Advances in Minimally Invasive and Endoscopic Neurosurgery

edited by Shunsuke Shibao

submission deadline 25 Feb 2027 | Viewed by 369 | Submission Open

Keywords: minimally invasive; endoscopic; keyhole; endonasal; transorbital; skull base; complications; surgical outcomes; technical innovations; robotic neurosurgery

(This special issue belongs to the Section Clinical Neurology)

Exercise, Rehabilitation, and Women’s Health: Clinical Perspectives in Sports Medicine

edited by

Do-yeon Kim

and

Dan Newmire

submission deadline 25 Feb 2027 | Viewed by 303 | Submission Open

Keywords: women’s health; exercise intervention; rehabilitation; exercise physiology; musculoskeletal health; healthy aging; resistance training; nutrition

(This special issue belongs to the Section Clinical Rehabilitation)

Cancer Prevention and Early Detection: Epidemiological Approaches and Public Health Strategies

edited by

Carmen Martos

and

Francesco Giusti

submission deadline 25 Feb 2027 | Viewed by 296 | Submission Open

Keywords: cancer prevention; cancer screening; risk factors; cancer treatment; health information systems; cancer registry; cancer inequalities

(This special issue belongs to the Section Epidemiology & Public Health)

Pelvic Floor Disorders: Emerging Perspectives on Therapeutic Approaches

edited by

María Luísa Sánchez-Ferrer

submission deadline 25 Feb 2027 | Viewed by 165 | Submission Open

Keywords: pelvic floor surgery; laparoscopic approach; quality of life; pelvic organ prolapse surgery; urinary and fecal incontinence; pelvic floor disorders

(This special issue belongs to the Section Obstetrics & Gynecology)

Colorectal Surgery: New Clinical Advances, Challenges and Future Directions

edited by

Lior Segev

submission deadline 25 Feb 2027 | Viewed by 95 | Submission Open

Keywords: colon surgery; colorectal surgery; colorectal cancer; IBD surgery; proctology; diverticular disease; diverticulitis; surgical outcomes

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Immunohematology: From Pathophysiology to Tailored Treatments

edited by

Giorgio Costagliola

submission deadline 28 Feb 2027 | 1 articles | Viewed by 4450 | Submission Open

Keywords: autoimmune cytopenia; hemophagocytic lymphohistiocytosis; inborn errors of immunity; lymphoproliferative diseases; malignancy; monoclonal antibodies; secondary immunodeficiency; vaccination

(This special issue belongs to the Section Immunology & Rheumatology)

Tumor Microenvironment—Current Status and Therapeutic Targets

edited by

Rashi Kalra

submission deadline 28 Feb 2027 | 2 articles | Viewed by 3989 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; immune checkpoint inhibitors; cancer biology; targeted therapies

(This special issue belongs to the Section Oncology)

Displaying special issue 1001-1050 on page 21 of 30.

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