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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances of Retinal and Vitreous Diseases: Current Status and Prospect

edited by Lorenzo De Angelis, Francesco Barca and Stanislao Rizzo

submission deadline 5 Sep 2026 | 6 articles | Viewed by 5735 | Submission Open

Keywords: vitreoretinal surgery; retinal multimodal imaging; gene therapy; retinal diseases; age-related macular degeneration; vascular retinal disease; imaging technologies in ophthalmology

(This special issue belongs to the Section Ophthalmology)

Challenges and Opportunities in Prenatal Diagnosis

edited by

Diana Massalska

and

Julia Bijok

submission deadline 10 Sep 2026 | 13 articles | Viewed by 18627 | Submission Open

Keywords: prenatal diagnosis; genetic testing; fetal imaging; fetal therapy; personalized prenatal medicine

(This special issue belongs to the Section Obstetrics & Gynecology)

New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles

edited by

Massimo Tusconi

, Serdar Dursun and

Germano Orru

submission deadline 10 Sep 2026 | 5 articles | Viewed by 17787 | Submission Open

Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD

(This special issue belongs to the Section Mental Health)

Non-Invasive Respiratory Support: Current Insights and Future Directions

edited by Giovanni Misseri and

Cesare Gregoretti

submission deadline 10 Sep 2026 | 4 articles | Viewed by 12398 | Submission Open

Keywords: respiratory failure; high-flow nasal cannula (HFNC); noninvasive ventilation (NIV); noninvasive positive pressure ventilation (NPPV); hypoxia; perioperative care; weaning; ICU; respiratory care; respiratory physiology; pneumology; home-care ventilation; artificial intelligence; personalized medicine

(This special issue belongs to the Section Respiratory Medicine)

Clinical Diagnosis and Management of Corneal Diseases

edited by

Eirini-Kanella Panagiotopoulou

Georgios Labiris

and Panagiota Ntonti

submission deadline 10 Sep 2026 | 4 articles | Viewed by 5781 | Submission Open

Keywords: corneal imaging; corneal disease diagnosis; corneal therapeutics; regenerative corneal treatments; artificial intelligence in corneal diagnostics; corneal cross-linking; lamellar keratoplasty

(This special issue belongs to the Section Ophthalmology)

Clinical Diagnosis and Therapeutic Approaches for Acute and Chronic Coronary Syndromes

edited by Rocco Antonio Montone

submission deadline 10 Sep 2026 | 2 articles | Viewed by 4887 | Submission Open

Keywords: coronary artery disease; clinical diagnosis; therapeutic approaches; atherosclerosis; risk factors; percutaneous cor-onary intervention; acute coronary syndrome; MINOCA; INOCA

(This special issue belongs to the Section Cardiology)

Updates on Physiotherapy in Pain Management

edited by

Stefanos Karanasios

and George Gioftsos

submission deadline 10 Sep 2026 | 4 articles | Viewed by 4079 | Submission Open

Keywords: pain management; physiotherapy; chronic pain; rehabilitation; pain assessment; patient outcomes; musculoskeletal; central sensitization; pain sensitivity; analgesia; pain modulation; exercise therapy; pain education; telerehabilitation; health-related quality of life; pain coping strategies

(This special issue belongs to the Section Clinical Rehabilitation)

Prevention, Diagnosis, and Clinical Treatment of Corneal Diseases

edited by Rossella Anna Maria Colabelli-Gisoldi and

Fabio Scarinci

submission deadline 10 Sep 2026 | 4 articles | Viewed by 3231 | Submission Open

Keywords: dry eye disease; cornea transplant; stem cell therapy; corneal imaging; cornea disease; deep anterior lamellar keratoplasty; descemet stripping automated endothelial keratoplasty; descemet membrane endothelial keratoplasty; keratoconus; eye bank

(This special issue belongs to the Section Ophthalmology)

Robotic Urologic Surgery: Clinical Applications and Advances

edited by Athanasios N. Kostakopoulos and

Nikolaos Kostakopoulos

submission deadline 10 Sep 2026 | 2 articles | Viewed by 1510 | Submission Open

Keywords: robotic surgery; robotic urology; advances in robotics; urologic surgery; minimally invasive urologic surgery; robotic partial nephrectomy; robotic radical prostatectomy

(This special issue belongs to the Section Nephrology & Urology)

Knee Surgery: Clinical Treatment and Management

edited by Nikolai Ramadanov

submission deadline 10 Sep 2026 | 2 articles | Viewed by 973 | Submission Open

Keywords: knee surgery; sports knee injuries; ligament reconstruction; meniscal surgery; cartilage repair; knee osteotomy; knee arthroplasty; clinical outcomes; surgical techniques

(This special issue belongs to the Section Orthopedics)

Clinical Management and Rehabilitation of Sports Injuries and Musculoskeletal Disorders

edited by

Francesco Oliva

Alessio Giai Via

and Francesco Cuozzo

submission deadline 10 Sep 2026 | 1 articles | Viewed by 599 | Submission Open

Keywords: sports injuries; musculoskeletal disorders; injury prevention; sports medicine; rehabilitation

(This special issue belongs to the Section Sports Medicine)

Management of Inguinal Hernia Surgery, Chronic Pain and Technological Future

edited by

Alfredo Moreno Egea

submission deadline 10 Sep 2026 | Viewed by 342 | Submission Open

Keywords: inguinal hernia; chronic pain; radical cure; technology; medical and surgery future

(This special issue belongs to the Section General Surgery)

Cardiac Intensive Care Units: Clinical Advances and Future Challenges

edited by Luca Baldetti

submission deadline 10 Sep 2026 | Viewed by 332 | Submission Open

Keywords: cardiac intensive care; heart failure; cardiogenic shock; mechanical circulatory support; invasive hemodynamic monitoring; acute cardiac care; shock; myocardial infarction

(This special issue belongs to the Section Cardiology)

Improving Short- and Long-Term Neurological Outcomes in Perioperative Anesthesia and Critical Care

edited by

Michele Salvagno

and

Marta Baggiani

submission deadline 10 Sep 2026 | Viewed by 323 | Submission Open

Keywords: perioperative brain injury; neuroprotection; multimodal neuromonitoring; delirium; neurocritical care; cerebral perfusion and oxygenation; precision anesthesia; artificial intelligence in critical care

(This special issue belongs to the Section Intensive Care)

Photodynamic Therapy and Optical Diagnostics in Cancer: Clinical Advances, Translational Innovation and Future Prospects

edited by

Waseem Jerjes

submission deadline 10 Sep 2026 | Viewed by 316 | Submission Open

Keywords: photodynamic therapy; optical diagnostics; photodiagnosis; optical imaging; cancer treatment; photosensitisers; light-based therapy; PDT dosimetry; fluorescence imaging; optical coherence tomography; raman spectroscopy; elastic scattering spectroscopy; hyperspectral imaging; image-guided surgery; optical biopsy; minimally invasive oncology; combination cancer therapies; translational photomedicine; clinical outcomes; precision oncology

(This special issue belongs to the Section Oncology)

Clinical Practice of Imaging in Coronary Interventional Therapy

edited by Nobuaki Suzuki

submission deadline 10 Sep 2026 | Viewed by 270 | Submission Open

Keywords: coronary artery disease; cardiac imaging; intravascular ultrasound; near-infrared spectroscopy; optical coherence tomography; fractional flow reserve computed tomography

(This special issue belongs to the Section Cardiology)

Cardiac Amyloidosis and Amyloid Cardiomyopathy: Advances in Cardiovascular Care

edited by Marcus Anthony Urey

submission deadline 10 Sep 2026 | Viewed by 239 | Submission Open

Keywords: amyloidosis; diagnostics; disease progression; restrictive cardiomyopathy; degraders; silencers; stabilizers

(This special issue belongs to the Section Cardiology)

Recent Advances in Lymphedema

edited by Shinsuke Akita

submission deadline 10 Sep 2026 | Viewed by 235 | Submission Open

Keywords: lymphedema; lymphaticovenular anastomosis (LVA); vascularized lymph node transfer (VLNT); immediate lymphatic reconstruction; indocyanine green lymphography; ultrasonography; bioimpedance analysis; imaging and staging of lymphedema; fibrosis and inflammation; patient-reported outcome measures

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Gynecologic Robotic Surgery: Evolution, Current Status and Future Directions

edited by Youn-Jee Chung

submission deadline 13 Sep 2026 | 2 articles | Viewed by 1497 | Submission Open

Keywords: laparoscopy; robot surgery; minimally invasive surgery; gynecology; endometriosis; myoma; adenomyosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Musculoskeletal Spine Disorders: Clinical Management, Rehabilitation Strategies, and Technological Innovations

edited by

Maria Chiara Maccarone

Nicola Manocchio

and Calogero Foti

submission deadline 14 Sep 2026 | 2 articles | Viewed by 1365 | Submission Open

Keywords: spine disorders; rehabilitation; physical exercise; low back pain; scoliosis; adolescent idiopathic scoliosis

(This special issue belongs to the Section Orthopedics)

Biomarkers and Diagnostics in Neurological Diseases

edited by Maria Ioanna Stefanou

submission deadline 15 Sep 2026 | 10 articles | Viewed by 20349 | Submission Open

Keywords: biomarkers; neurological diseases; diagnosis; lipoprotein(a); neurofilament protein; tau peptide; neuroimaging

(This special issue belongs to the Section Clinical Neurology)

Advances in Diagnosis and Treatment of Endometriosis

edited by

Arrigo Fruscalzo

and

Anis Feki

submission deadline 15 Sep 2026 | 6 articles | Viewed by 11887 | Submission Open

Keywords: endometriosis; adenomyosis; diagnosis; classification; therapy; progesterone

(This special issue belongs to the Section Obstetrics & Gynecology)

Thyroid Disease: Updates from Diagnosis to Treatment: 2nd Edition

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 15 Sep 2026 | 7 articles | Viewed by 9643 | Submission Open

Keywords: autoimmune thyroid diseases; thyroiditis; thyroid cancers; PET/CT; hyperthyroidism

(This special issue belongs to the Section Endocrinology & Metabolism)

Current Challenges in Clinical Dentistry: 3rd Edition

edited by

Eiji Tanaka

and

Susumu Abe

submission deadline 15 Sep 2026 | 2 articles | Viewed by 4957 | Submission Open

Keywords: artificial intelligence; clinical dentistry; cutting-edge device and technology; dental material; challenging hypothesis; preventive dentistry; sleep medicine; digital dentistry; smart dentistry; stomatognathic function

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Plastic and Reconstructive Surgery: Clinical Advances and Future Opportunities

edited by Rami S Kantar

submission deadline 15 Sep 2026 | 5 articles | Viewed by 4541 | Submission Open

Keywords: plastic surgery; reconstructive surgery; cleft lips; palates; post-traumatic reconstruction; facial transplantation; craniofacial surgery; cleft surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Latest Advances in Thoracic Surgery: 2nd Edition

edited by

Hideki Ujiie

submission deadline 15 Sep 2026 | 2 articles | Viewed by 4172 | Submission Open

Keywords: lung cancer; surgical oncology; robotic surgery; thoracic surgery; lung diseases; minimally invasive surgery

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Obesity and Bariatric Surgery—2nd Edition

edited by Valentin Mocanu and Jerry Dang

submission deadline 15 Sep 2026 | 4 articles | Viewed by 3348 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; anti-obesity medications; obesity treatment

(This special issue belongs to the Section Endocrinology & Metabolism)

Risk Prediction in Mechanical Circulatory Support (MCS) and Cardiac Transplantation

edited by

Nandini Nair

submission deadline 15 Sep 2026 | 3 articles | Viewed by 3159 | Submission Open

Keywords: advanced heart failure; mechanical circulatory support (MCS); cardiac transplantation; heart transplantation; risk prediction

(This special issue belongs to the Section Cardiology)

Clinical Management and Challenges of Sepsis and Septic Shock

edited by

Matteo Guarino

and

Michele Domenico Spampinato

submission deadline 15 Sep 2026 | 4 articles | Viewed by 1953 | Submission Open

Keywords: sepsis; septic shock; hemodynamic management; biomarkers; cardiovascular dysfunction; point-of-care ultrasound; precision medicine; emergency medicine; critical care

(This special issue belongs to the Section Intensive Care)

Sports Injuries: Emerging Trends in Risk Mitigation, Management and Recovery

edited by

Luis Suárez-Arrones

and Jose Asian-Clemente

submission deadline 15 Sep 2026 | 3 articles | Viewed by 1390 | Submission Open

Keywords: injury prevention; rehabilitation; muscle; return-to-sport; surgery; therapy; testing; regenerative medicine; ultrasound; MRI; sports medicine

(This special issue belongs to the Section Sports Medicine)

Advances in Pancreatic Cancer: Diagnosis and Therapy

edited by Eleonora Lai,

Nicola Silvestris

and

Mario Scartozzi

submission deadline 15 Sep 2026 | 1 articles | Viewed by 1380 | Submission Open

Keywords: pancreatic cancer diagnosis; endoscopic ultrasound; neoadjuvant chemotherapy; surgical resection; targeted therapy; immunotherapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cancers: Clinical Radiation Therapy

edited by Julianne M. Pollard-Larkin

submission deadline 15 Sep 2026 | 1 articles | Viewed by 1020 | Submission Open

Keywords: reirradiation; tissue tolerance; image registration; treatment planning; dose accumulation

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Esophageal and Upper Gastrointestinal Surgery: Clinical Advances and Practical Updates

edited by

Pedro Serralheiro

and Peter Grimminger

submission deadline 15 Sep 2026 | 2 articles | Viewed by 971 | Submission Open

Keywords: esophageal cancer; gastric cancer; upper GI surgery; surgical oncology; benign upper GI surgery; surgical innovation; surgical outcomes; surgical guidelines; robotic surgery; minimally invasive surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Cardiac Resynchronization Treatment: 2nd Edition

edited by

George Leventopoulos

, Konstantinos A. Gatzoulis, Konstantinos Aronis and

Dimitris L. Tsiachris

submission deadline 15 Sep 2026 | 1 articles | Viewed by 970 | Submission Open

Keywords: conduction system; risk stratification; resynchronization; cardiac pacing; sudden cardiac death

(This special issue belongs to the Section Cardiology)

Cardiovascular Disease in MASLD: New Advances in Therapeutic Targets

edited by

Alfredo Caturano

submission deadline 15 Sep 2026 | 1 articles | Viewed by 952 | Submission Open

Keywords: MASLD; cardiovascular disease (CVD); metabolic dysfunction; steatotic liver disease; insulin resistance; dyslipidemia; atherosclerosis; inflammation; GLP-1 receptor agonists; SGLT2 inhibitors; lipid-lowering therapies; cardiometabolic risk; clinical trials; therapeutic targets

(This special issue belongs to the Section Cardiovascular Medicine)

Cardiac Arrest: Appropriate Prognostication and Therapeutic Options

edited by

Jae Hoon Lee

and Jin-hong Min

submission deadline 15 Sep 2026 | 1 articles | Viewed by 787 | Submission Open

Keywords: cardiac arrest; prognosis; hypothermia, induced; resuscitation; magnetic resonance imaging; electroencephalog-raphy; blood pressure; hypoxia-ischemia, brain; extracorporeal membrane oxygenation

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Endoscopic Techniques for Gastrointestinal Diseases

edited by Alberto Tringali

submission deadline 15 Sep 2026 | 1 articles | Viewed by 625 | Submission Open

Keywords: hepatobiliary disease; pancreatic disease; ERCP; interventional EUS; cholangiopancreatoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Pulmonary Arterial Hypertension: Emerging Therapies and Clinical Outcomes

edited by Namita Sood

submission deadline 15 Sep 2026 | Viewed by 375 | Submission Open

Keywords: pulmonary arterial hypertension (PAH); PAH therapy; emerging treatments; sotatercept; inhaled therapy; targeted pharmacotherapy; combination therapy; therapeutic efficacy; pulmonary vascular imaging

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Endodontics

edited by

Vincenzo Tosco

submission deadline 15 Sep 2026 | Viewed by 372 | Submission Open

Keywords: endodontics; vital pulp therapy; minimally invasive endodontics; clinical endodontic techniques; bioactive sealers

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

State of the Art of Lung Surgery: Modern Horizons in Lung Cancer Treatment

edited by

Alessio Mariolo

and Edouard Sage

submission deadline 15 Sep 2026 | Viewed by 330 | Submission Open

Keywords: lung-cancer-surgery; thoracic oncology; RATS; VATS; induction therapy; neoadjuvant-immunotherapy; non-intubated thoracic surgery; NITS; segmentectomy; lung-sparing surgery; 3D-reconstruction

(This special issue belongs to the Section General Surgery)

Recent Clinical Updates on Vascular and Endovascular Surgery

edited by

Mª Lourdes Del Río-Solá

and

Sergi Bellmunt-Montoya

submission deadline 15 Sep 2026 | Viewed by 322 | Submission Open

Keywords: vascular surgery; endovascular surgery; aortic disease; abdominal aortic aneurysm; peripheral arterial disease; chronic venous disease; endovascular repair; open vascular surgery

(This special issue belongs to the Section Vascular Medicine)

Cardiac Imaging in the Clinical Management of Heart Failure

edited by Maria Concetta Pastore

submission deadline 15 Sep 2026 | Viewed by 293 | Submission Open

Keywords: heart failure; cardiac imaging; echocardiography; cardiac magnetic resonance; computed tomography; nuclear imaging

(This special issue belongs to the Section Cardiology)

Innovations and Advancements in Spine Surgery

edited by Mitchell K. Ng

submission deadline 15 Sep 2026 | Viewed by 293 | Submission Open

Keywords: spine surgery; minimally invasive spine surgery; robotic-assisted spine surgery; spinal navigation; endoscopic spine surgery; spinal implant; biologics and regenerative therapies; perioperative optimization; patient-reported outcomes; value-based spine care; surgical innovation

(This special issue belongs to the Section Orthopedics)

New Insights into Acute Care and Emergency Surgery: 2nd Edition

edited by Jacob Chen and Avi Benov

submission deadline 15 Sep 2026 | Viewed by 263 | Submission Open

Keywords: trauma surgery; emergency surgery; acute care; anesthesia; ICU

(This special issue belongs to the Section General Surgery)

Innovations in Advanced Heart Failure Detection and Management

edited by Vinh Q. Chau and Nikhil Narang

submission deadline 15 Sep 2026 | Viewed by 241 | Submission Open

Keywords: advanced heart failure; systolic heart failure; mechanical circulatory support; left ventricular assist device; heart transplantation outcomes

(This special issue belongs to the Section Cardiology)

Application of Physiotherapy in Clinical Rehabilitation

edited by

Kyeongbong Lee

submission deadline 17 Sep 2026 | 2 articles | Viewed by 1123 | Submission Open

Keywords: therapeutic exercise; neurological rehabilitation; musculoskeletal physiotherapy; cardiopulmonary rehabilitation; intensive care unit (ICU) rehabilitation; gait and balance; pediatric and geriatric physical therapy; sports physical therapy; rehabilitation technology

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Advances in Kidney Transplantation

edited by

Florin Ioan Elec

and

Oana Antal

submission deadline 18 Sep 2026 | 7 articles | Viewed by 9089 | Submission Open

Keywords: kidney transplantation; immunosuppression; graft survival; donor risk assessment; post-transplant management; rejection and tolerance; precision medicine in transplantation

(This special issue belongs to the Section Nephrology & Urology)

Clinical Perspectives in Pediatric Surgery: From Neonatal Procedures to Adolescent Care

edited by

Mirko Bertozzi

and

Giovanna Riccipetitoni

submission deadline 18 Sep 2026 | 1 articles | Viewed by 869 | Submission Open

Keywords: mini invasive surgery; transitional care of rare diseases; newborn surgery; long-term follow up; congenital malformations

(This special issue belongs to the Section Clinical Pediatrics)

Current Trends in Implant Dentistry

edited by Marco Toia

submission deadline 20 Sep 2026 | 9 articles | Viewed by 29889 | Submission Open

Keywords: digital implant planning; osseointegration; guided surgery (static and dynamic); bone regeneration; zygomatic and pterygoid implants; 3D previsualization; craniofacial analysis; peri-implant diseases; immediate loading

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advancements in Spine Surgery: Best Practices and Outcomes

edited by

Mitsuru Yagi

submission deadline 20 Sep 2026 | 12 articles | Viewed by 26725 | Submission Open

Keywords: adult spinal deformity; scoliosis; frailty; biological age; big data analysis

(This special issue belongs to the Section Orthopedics)

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